Immune Response News and Research

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Microglia may play key role in slowing progression of prion diseases, research suggests

Prion diseases are slow degenerative brain diseases that occur in people and various other mammals. No vaccines or treatments are available, and these diseases are almost always fatal. Scientists have found little evidence of a protective immune response to prion infections.

17 May 2018

Study provides new clues to how Ebola virus causes damage in the retina

A new study, conducted by the researchers from the University of Liverpool, published in JAMA Ophthalmology identifies the specific characteristics of Ebola retinal lesions, which provide further clues as to how the virus travels to the retina and causes damage.

15 May 2018

Smoke from fires may pose threat to orangutans, finds study

Orangutans, already critically endangered due to habitat loss from logging and large-scale farming, may face another threat in the form of smoke from natural and human-caused fires, a Rutgers University-New Brunswick study finds.

15 May 2018

Researchers discover unique mechanism that regulates tumor growth in lung cancer

Lung cancer is the third most common type of cancer in Germany and the disease affects both men and women. However, immunotherapies are successful in only 20 percent of cases.

14 May 2018

Researchers manipulate bacterial species in the gut using diet

Scientists from Stanford University School of Medicine have shown that by manipulating diet in a mouse model, it is possible to favor the engraftment of a specific bacterial strain over others.

10 May 2018

Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material, necessitating the use of complex drugs and techniques to suppress the host's immune response.

10 May 2018

Neon Therapeutics evaluates safety, efficacy of NEO-PV-01 in combination with KEYTRUDA and chemotherapy

Neon Therapeutics, a clinical-stage immuno-oncology company developing neoantigen-based therapeutics, today announced that it has treated the first patient in a clinical trial evaluating its proprietary personal neoantigen vaccine, NEO-PV-01, in combination with Merck's anti-PD-1 therapy, KEYTRUDA®, along with chemotherapy.

8 May 2018

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center.

8 May 2018

Cancer scientists confirm oligometastasis hypothesis

In 1995, two University of Chicago-based cancer specialists suggested there was an intermediate state - somewhere between curable localized cancers and lethal widespread disease - for patients with metastatic cancer.

7 May 2018

Researchers uncover role of ROS in clearing dead cells

If dead cells accumulate in the body, they can contribute to inflammation and pre-dispose individuals to multiple chronic inflammatory conditions such as rheumatoid arthritis, cardiovascular diseases, Crohn's disease or lupus by uncharacterized pathways.

7 May 2018

Phase 2 clinical study of universal influenza vaccine begins in the United States

A Phase 2 clinical trial of an investigational universal influenza vaccine intended to protect against multiple strains of the virus has begun in the United States.

4 May 2018

New research illustrates how beneficial bacteria establish robust gut colonization

The mammalian gut is warm, moist, and incredibly nutrient-rich--an environment that is perfect for bacterial growth. The communities of "good bacteria" in the gut, commonly referred to as the microbiome, are vital partners for the body, helping to digest fiber, extract nutrients, and prevent various diseases.

4 May 2018

Ocular oncologists link immunotherapy with potentially vision-robbing side effect

New immunotherapy treatments offer a remarkable chance for survival for patients with advanced melanoma and hard-to-treat cancers of the bladder, kidney and lung.

4 May 2018

Study shows how bacterial toxins can cripple normal cellular activity

Bacterial toxins can wreak mass havoc within cells by shutting down multiple essential functions at once, a new study has found.

4 May 2018

New study evaluates expression of PD-L1 in human medulloblastoma

This study evaluated the expression of PD-L1 and markers of immune mediated resistance in human medulloblastoma, the most common malignant pediatric brain tumor.

3 May 2018

Mother's milk found to have SWAT team of immune cells

Immune cells that are ready to take action against invaders like bacteria have been found in women's breast milk, researchers say.

3 May 2018

Improving the Diagnosis of Cardiac Sarcoidosis

Cardiac sarcoidosis is an inflammatory disease of the heart that results in various clinical manifestations. Dr Nadera Sweiss discusses her research in the field of sarcoidosis and how diet can influence the diagnosis of the condition.

30 Apr 2018

Researchers use CRISPR/Cas9 technique to turn off gene that regulates cholesterol levels in adult mice

Biomedical engineers at Duke University have used a CRISPR/Cas9 genetic engineering technique to turn off a gene that regulates cholesterol levels in adult mice, leading to reduced blood cholesterol levels and gene repression lasting for six months after a single treatment.

27 Apr 2018

New CAR-T therapy could provide safer, more effective cancer treatment

There have been few cancer treatments with such a promising future as using the patient's own immune system.

27 Apr 2018

New implantable device furnishes islet cells with their own supply of oxygen

Since the 1960s, researchers have been interested in the possibility of treating type 1 diabetes by transplanting islet cells -- the pancreatic cells that are responsible for producing insulin when blood glucose concentration increases.

25 Apr 2018

Immune Response News and Research

Microglia may play key role in slowing progression of prion diseases, research suggests

Study provides new clues to how Ebola virus causes damage in the retina

Smoke from fires may pose threat to orangutans, finds study

Researchers discover unique mechanism that regulates tumor growth in lung cancer

Researchers manipulate bacterial species in the gut using diet

Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

Neon Therapeutics evaluates safety, efficacy of NEO-PV-01 in combination with KEYTRUDA and chemotherapy

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Cancer scientists confirm oligometastasis hypothesis

Researchers uncover role of ROS in clearing dead cells

Phase 2 clinical study of universal influenza vaccine begins in the United States

New research illustrates how beneficial bacteria establish robust gut colonization

Ocular oncologists link immunotherapy with potentially vision-robbing side effect

Study shows how bacterial toxins can cripple normal cellular activity

New study evaluates expression of PD-L1 in human medulloblastoma

Mother's milk found to have SWAT team of immune cells

Improving the Diagnosis of Cardiac Sarcoidosis

Researchers use CRISPR/Cas9 technique to turn off gene that regulates cholesterol levels in adult mice

New CAR-T therapy could provide safer, more effective cancer treatment

New implantable device furnishes islet cells with their own supply of oxygen

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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