Immune Response News and Research

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Researchers unravel immunopathogenesis of Johne's disease

A research team has unraveled the immunopathogenesis of Johne's disease, a chronic bovine disease that has caused endemics in Japan and many other countries, placing financial burdens on cattle farmers.

2 Apr 2018

Research reveals role of colon signaling pathway in development of IBD

The intestine encounters more foreign substances, and potential toxins, than other parts of the body, so it is not surprising that a healthy gut is maintained by the tight control of immune responses.

30 Mar 2018

Researchers discover major cause of treatment failure in Chagas disease

Researchers at the University of Georgia have discovered that dormancy of the parasite Trypanosoma cruzi prevents effective drug treatment for Chagas disease, which kills more than 50,000 people each year in Central and South America and is a growing threat in the United States and Europe.

30 Mar 2018

Study shows limitations of AAV gene therapy in treating hereditary adrenal disorders

A new study has definitively shown that a single treatment with gene therapy using adeno-associated viral (AAV) vector gene delivery to replace the defective gene responsible for congenital adrenal hyperplasia (CAH) will only temporarily alleviate the hereditary disorder.

29 Mar 2018

New $3.2 million grant funds research to advance promising malaria vaccine

The Global Health Innovative Technology Fund has awarded the University of Florida and partners in the United States and Japan $3.2 million to advance a promising vaccine to prevent transmission of malaria.

29 Mar 2018

Macrophages stimulated to produce potent anti-inflammatory molecule

Researchers have discovered that macrophages, which play a key role in inflammation, also produce an anti-inflammatory molecule called itaconate.

29 Mar 2018

Single high-fat meal can set the stage for cardiovascular disease

A single high-fat milkshake, with a fat and calorie content similar to some enticing restaurant fare, can quickly transform our healthy red blood cells into small, spiky cells that wreak havoc inside our blood vessels and help set the perfect stage for cardiovascular disease, scientists report.

29 Mar 2018

Phase I clinical trial of HIV vaccines to begin in the U.S.

A Phase I clinical trial testing the safety of vaccines that might have the potential to prevent HIV infection will begin this month at four sites in the United States, marking the latest step in a three-decade quest at UMass Medical School to harness the power of DNA vaccines in addressing a major global health threat.

28 Mar 2018

Antibiotic use linked to higher risk of severe viral disease in mice

People infected with West Nile virus can show a wide range of disease. Some develop life-threatening brain infections. Others show no signs of infection at all. One reason for the different outcomes may lie in the community of microbes that populate their intestinal tracts.

27 Mar 2018

Antibody sweeps away Alzheimer's plaques in mice

Years before people start showing characteristic symptoms of Alzheimer's disease, sticky plaques begin forming in their brains, damaging nearby cells. For decades, doctors have sought ways to clear out these plaques as a way to prevent or treat the disease.

27 Mar 2018

Two immunotherapies used together for the first time to fight against solid tumors

Two immunotherapies - one that enables the T-cells a patient already has to better attack a tumor and another that can produce an independent and vigorous immune response - are being given together for the first time to help more patients wage a stronger war on a wide range of solid tumors, researchers say.

26 Mar 2018

Immune cells can repopulate in the retina after elimination, mice study shows

Immune cells called microglia can completely repopulate themselves in the retina after being nearly eliminated, according to a new study in mice from scientists at the National Eye Institute.

21 Mar 2018

Scientists uncover new answers to cell aging in children with rare, fatal disease

In a recent paper published in Cell Reports, Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease.

20 Mar 2018

American Gene Technologies receives second immuno-oncology patent

American Gene Technologies International Inc., a leading gene and cell therapy company, today announced receipt of a second immuno-oncology patent on the stimulation of gamma delta T cells for treating solid tumors in epithelial cancers.

20 Mar 2018

Blood donor scraps help researchers to discover new insight into human immune system

Iowa State University researchers have discovered new insight into the human immune system from an unlikely source, the leftover material from blood donation banks.

16 Mar 2018

Researchers find specific cellular structures that orchestrate rapid immunologic memory

With every infection or vaccination, memory cells form that the body uses to remember the pathogen. This has been known for decades - but the structure of this cellular immunologic memory has previously proven impossible to pin down.

9 Mar 2018

Modifying Oncolytic Adenoviruses to Target Pancreatic Cancer

Pancreatic cancer is one of the less common but deadliest cancers. Modified oncolytic adenoviruses represent an alternative to chemotherapy and targeted therapies, which have a high mortality rate.

9 Mar 2018

Study seeks to examine whether gut bacteria cause brain dysfunction in sepsis patients

Surviving a critical illness is no small feat, but it's only half the battle for many patients. Serious complications can still result after an illness appears to have cleared.

8 Mar 2018

New study examines origin of cryptococcosis within the central nervous system

A particular fungal infection is responsible for more than 220,000 cases of cryptococcosis worldwide each year in people with HIV and AIDS, with nearly 181,000 of those resulting in death.

8 Mar 2018

Researchers identify new mechanism to disrupt HIV latency

HIV, the virus that causes AIDS, has a secret life. Though anti-retroviral therapy can reduce its numbers, the virus can hide and avoid both treatments and the body's immune response.

8 Mar 2018