Necrosis News and Research

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Researchers develop machine learning tool to predict necrotizing enterocolitis in premature infants

Necrotizing enterocolitis (NEC) is a life-threatening intestinal disease of prematurity. Characterized by sudden and progressive intestinal inflammation and tissue death, it affects up to 11,000 premature infants in the United States annually, and 15-30% of affected babies die from NEC.

11 Aug 2020

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed.

7 Aug 2020

New computational model can help determine drug viability

About 50% of people who take the drug infliximab for inflammatory bowel diseases, such as Crohn's disease, end up becoming resistant or unresponsive to it.

5 Aug 2020

New bivalent vaccine delivers robust cell-mediated and humoral immunity against SARS-CoV-2

In a groundbreaking bioRxiv study, US researchers demonstrate the capability of next-generation bivalent human adenovirus serotype 5 (hAd5) vaccine for inducing both cellular and humoral immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – using both an S protein sequence optimized for cell surface expression and a conserved nucleocapsid antigen designed to be transported to the endosomal subcellular compartment.

2 Aug 2020

Scientists are developing AI tools that can benefit certain cancer patients

Case Western Reserve University scientists are developing artificial intelligence (AI) tools to help surgeons and oncologists identify the subtle but critical differences between a recurring tumor and damaged non-cancerous tissue on post-operative MRI scans of certain cancer patients.

29 Jul 2020

Study reveals manifold applications of cytokine transcriptional response modules in COVID-19

In a recent bioRxiv* study, UK researchers used interleukin modules to investigate the pathology of coronavirus disease (COVID-19).

27 Jul 2020

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Now, a new study published on the preprint server bioRxiv in July 2020 presents an engineered transgenic mouse that reproduces the functional and clinical characteristics of severe human SARS-CoV-2 infection.

21 Jul 2020

Study identifies toxicological risks of environmental pollutants in finless porpoises

A recent study just published in Environmental Science & Technology identified the toxicological risks of environmental pollutants to finless porpoises (Neophocaena asiaeorientalis).

20 Jul 2020

Type 1 interferon deficiency as a biomarker for detecting patients at risk of severe COVID-19

Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.

17 Jul 2020

Evidence of SARS-CoV-2 placental infection in mild COVID-19

Now, a new study published on the preprint server medRxiv* in July 2020 reveals evidence of placental infection and hypoxia, despite the lack of serious symptoms in the mother.

16 Jul 2020

Breakthrough discovery could lead to ‘kinder’ treatments for childhood bone cancer

Researchers at the University of East Anglia and University of Manchester have made an important breakthrough that could lead to ‘kinder’ treatments for children with bone cancer, and save lives.

13 Jul 2020

Faulty immune response to SARS-CoV-2 one of the main causes of death

A new study published on the preprint server medRxiv in July 2020 describes the organ and tissue-specific spread of the virus causing the current COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

7 Jul 2020

Study identifies a promising way to delay the onset of Alzheimer's disease

Currently we are facing a dementia epidemic, estimations showing that by 2050 approximately 131 million people will be affected. Every 7 seconds a patient is diagnosed worldwide.

2 Jul 2020

BMI should be assessed in management of COVID-19 patients

A new study published on the preprint server medRxiv* in June 2020 reports that obesity is a risk factor of composite poor outcome of COVID-19 disease. On the other hand, COVID-19 patients with 'composite poor outcome' have higher BMI. Therefore, BMI should be assessed in the management of COVID-19 patients, and special attention should be given to patients with obesity.

1 Jul 2020

Oral hygiene and severity of COVID-19 – the connection

Their study titled, “Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections?” was published in the latest issue of the journal British Dental Journal.

30 Jun 2020

Research team profiles the body's immune response to COVID-19

A team from Lawson Health Research Institute and Western University are the first in the world to profile the body's immune response to COVID-19.

25 Jun 2020

Anti-TNF drug preserves beta-cell function in newly diagnosed pediatric patients with Type 1 diabetes

In research led by a University at Buffalo pediatric endocrinologist, a drug called golimumab showed that it preserved beta-cell function in children and young adults with newly diagnosed Type 1 diabetes, according to findings from a Phase 2 study.

16 Jun 2020

Progression and severity of COVID-19 highly dependant on cytokine changes

A new review paper by the researchers from Spain, published in the journal Cytokine & Growth Factor Reviews, demonstrates how changes in the levels of cytokines and other biomolecules are associated with the presence and more serious prognosis of coronavirus disease (COVID-19).

11 Jun 2020

Turning autoimmunity drugs into anti-cancer treatments

Professor Mark Cragg speaks to News-Medical about his research which involves turning autoimmunity drugs into anti-cancer treatments.