Immune Response News and Research

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Synthetic scaffold loaded with cancer-fighting T cells effectively shrinks solid tumors

Cellular therapy hasn't had much success in fighting solid tumors, partly because it's been difficult to deliver anti-cancer T cells to the tumors.

25 Apr 2017

UTSW researchers develop new nanoparticle vaccine immunotherapy that targets multiple tumor types

Researchers from UT Southwestern Medical Center have developed a first-of-its-kind nanoparticle vaccine immunotherapy that targets several different cancer types.

24 Apr 2017

High-fat diet and obesity drive liver immune cells to promote metabolic syndrome

A high-fat diet and obesity turn "hero" virus-fighting liver immune cells "rogue", leading to insulin resistance, a condition that often results in type 2 diabetes, according to research published today in Science Immunology.

21 Apr 2017

Researchers develop new approach to protect stem cell recipients from graft-versus-host disease

Stem cell transplants can save lives, for example in patients with leukemia. However, these treatments are not free of risks. One complication that may occur is graft-versus-host disease (GVHD), basically donor-derived immune cells attacking the recipient’s body.

21 Apr 2017

Preliminary study reveals promising results of new treatment for progressive MS

A small, preliminary study may show promise of a new type of treatment for progressive multiple sclerosis (MS).

20 Apr 2017

Researchers reveal molecular details of how pathogens survive human immune responses

Researchers have uncovered molecular details of how pathogenic bacteria fight back against the human immune response to infection.

20 Apr 2017

Researcher aims to eliminate chemotherapy-resistant ovarian tumors using virus treatment

In some cases, the Lassa virus starts with a fever and general weakness, moving toward headache, muscle pain, possible facial swelling, deafness, and worse. About 15 percent of patients hospitalized with severe cases die.

20 Apr 2017

LIH scientists discover unknown immune activation mechanism to ward off pathogens

Scientists of the Luxembourg Institute of Health have discovered a so far unknown molecular mechanism by which the human immune system activates its immune cells: T cells, a particular type of white blood cells, effectively ward off pathogens if a gene known as Gclc is expressed within them.

19 Apr 2017

Researchers show how dengue virus employs multiple tactics to evade immune detection

For the human body to mount an immune response to a viral infection, host cells must identify the viral invader and trigger a signaling pathway. This signal then prompts the immune system to attack and subdue the pathogen.

19 Apr 2017

Bacteriophages may help combat antibiotic-resistant 'superbugs'

Viruses that specifically kill bacteria, called bacteriophages, might one day help solve the growing problem of bacterial infections that are resistant to antibiotic treatment.

18 Apr 2017

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

A research team led by St. Jude Children's Research Hospital immunologists has revealed a previously unknown immune machinery that goes awry to trigger the inflammatory disease neutrophilic dermatosis.

18 Apr 2017

Air pollution may directly affect biology of upper airways to cause chronic sinus problems

Although human population studies have linked air pollution to chronic inflammation of nasal and sinus tissues, direct biological and molecular evidence for cause and effect has been scant.

18 Apr 2017

Innovate UK funds new, economic vaccine to halt spread of 'zoonotic' infectious diseases

A team of international scientists led by Dr. Michael Jarvis at the University of Plymouth has received funding in excess of £408,000 from Innovate UK to develop a new and economic vaccine designed to halt the spread of highly pathogenic 'zoonotic' (spreading from animals to humans) infectious diseases.

18 Apr 2017

Vaccine-chemotherapy combination may improve survival for glioblastoma patients

A vaccine targeting cytomegalovirus (CMV) antigen pp65, combined with high-dose chemotherapy (temozolomide), improved both progression-free survival and overall survival for a small group of glioblastoma (GBM) patients.

17 Apr 2017

NIH study provides unprecedented detail on host response to Ebola virus disease

Analysis of daily gene activation in a patient with severe Ebola virus disease cared for at the National Institutes of Health (NIH) in 2015 found changes in antiviral and immune response genes that pinpointed key transition points in the response to infection.

12 Apr 2017

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

A microscopic corn-and-shrimp cocktail could eventually make DNA-based vaccinations and cancer-treating gene therapies an easier pill to swallow, according to new research from the University of Nebraska-Lincoln.

12 Apr 2017

Scientists solve structure of protein crucial to reproduction and spread of Zika virus

Zika virus is a mosquito-borne infectious disease linked to certain birth defects in infants in South and Central America and the United States.

11 Apr 2017

Programmed proteins could lead to inexpensive malaria vaccine

Despite decades of malaria research, the disease still afflicts hundreds of millions and kills around half a million people each year - most of them children in tropical regions.

10 Apr 2017

Viral trigger may underlie development of celiac disease

Reovirus, which commonly infects humans without causing any symptoms, may trigger an immune response to gluten that causes celiac disease, report US researchers.

10 Apr 2017

Researchers uncover critical pathway that helps pancreatic cancer cells turn off immune system

Researchers at NYU Langone Medical Center and its Perlmutter Cancer Center have uncovered a critical pathway by which pancreatic cancer cells turn off the immune system charged with attacking them. The findings appear in a paper published online in Nature Medicine April 10.

7 Apr 2017

Immune Response News and Research

Synthetic scaffold loaded with cancer-fighting T cells effectively shrinks solid tumors

UTSW researchers develop new nanoparticle vaccine immunotherapy that targets multiple tumor types

High-fat diet and obesity drive liver immune cells to promote metabolic syndrome

Researchers develop new approach to protect stem cell recipients from graft-versus-host disease

Preliminary study reveals promising results of new treatment for progressive MS

Researchers reveal molecular details of how pathogens survive human immune responses

Researcher aims to eliminate chemotherapy-resistant ovarian tumors using virus treatment

LIH scientists discover unknown immune activation mechanism to ward off pathogens

Researchers show how dengue virus employs multiple tactics to evade immune detection

Bacteriophages may help combat antibiotic-resistant 'superbugs'

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

Air pollution may directly affect biology of upper airways to cause chronic sinus problems

Innovate UK funds new, economic vaccine to halt spread of 'zoonotic' infectious diseases

Vaccine-chemotherapy combination may improve survival for glioblastoma patients

NIH study provides unprecedented detail on host response to Ebola virus disease

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

Scientists solve structure of protein crucial to reproduction and spread of Zika virus

Programmed proteins could lead to inexpensive malaria vaccine

Viral trigger may underlie development of celiac disease

Researchers uncover critical pathway that helps pancreatic cancer cells turn off immune system

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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