Immune Response News and Research

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Researchers discover promising target for treatment of leishmaniasis

Each year, about 2 million people contract leishmaniasis, a parasitic disease transmitted by the bite of a sand fly. The cutaneous form of the disease results in disfiguring skin ulcers that may take months or years to heal and in rare cases can become metastatic, causing major tissue damage.

24 Feb 2017

Scientists devise novel DNA vaccine approach against important cancer antigen targets

Scientists at The Wistar Institute and Inovio Pharmaceuticals, Inc. have devised a novel DNA vaccine approach through molecular design to improve the immune responses elicited against one of the most important cancer antigen targets. Study results were published in the journal Molecular Therapy.

24 Feb 2017

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

For the first time a "tipping point" molecular link between the blood sugar glucose and Alzheimer's disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer's.

24 Feb 2017

NSAIDs could potentially be repurposed as life-saving treatment for sepsis, research suggests

A potentially life-saving treatment for sepsis has been under our noses for decades in the non-steroidal anti-inflammatory drugs most people have in their medicine cabinets, a new University of Colorado Boulder study suggests.

23 Feb 2017

Study reveals mechanisms behind Zika transmission to fetus and adverse perinatal outcomes

Johns Hopkins researchers say that in early pregnancy in mice with complete immune systems, Zika virus can cross the placenta -- intended to protect the developing fetus -- and appears to lead to a high percentage of miscarriages and to babies born with thin brain tissue and inflammation in brain cells.

23 Feb 2017

Penn-led researchers gain better understanding of how T cells support long-lived plasma cells

If you've ever wondered how a vaccine given decades ago can still protect against infection, you have your plasma cells to thank. Plasma cells are long-lived B cells that reside in the bone marrow and churn out antibodies against previously encountered vaccines or pathogens.

22 Feb 2017

Treating multiple myeloma with rabbit virus eliminates majority of malignant cells, study shows

Treating multiple myeloma (MM) with myxoma virus (MYXV) eliminated a majority of malignant cells in preclinical studies, report investigators at the Medical University of South Carolina and elsewhere in an article published online on December 7, 2016 by Molecular Therapy -- Oncolytics.

22 Feb 2017

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

Melanoma patients' response to a major form of immunotherapy is associated with the diversity and makeup of trillions of potential allies and enemies found in the digestive tract, researchers at The University of Texas MD Anderson Cancer Center report at the ASCO-Society for Immunotherapy in Cancer meeting in Orlando.

22 Feb 2017

Scientists explore role of salt and immune system in raising blood pressure of females

Many of us have noted how our hands and feet swell after eating too much salt. Now scientists are exploring how high salt intake can also make cells throughout the body of females swell, rupture, dump their contents and die, triggering an immune reaction that contributes to chronic high blood pressure.

22 Feb 2017

NIH launches new study to test experimental vaccine that targets mosquito-transmitted diseases

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has launched a Phase 1 clinical trial to test an investigational vaccine intended to provide broad protection against a range of mosquito-transmitted diseases, such as Zika, malaria, West Nile fever and dengue fever, and to hinder the ability of mosquitoes to transmit such infections.

22 Feb 2017

Investigational malaria vaccine protects against multiple strains, study shows

An investigational malaria vaccine has protected a small number of healthy U.S. adults from infection with a malaria strain different from that contained in the vaccine, according to a study published today in the Proceedings of the National Academy of Sciences.

22 Feb 2017

Danish research may pave way for immunological treatment of cancer

Researchers from Aarhus University have found an important piece of the puzzle leading towards an understanding of how our innate immune system reacts against viral infections and recognises foreign DNA, for example from dying cancer cells.

21 Feb 2017

UofL researcher receives NIH grant to study microbes responsible for protecting against malaria

Nathan Schmidt, Ph.D., has published research showing that microbes in the gut of mice can affect the severity of illness suffered from infection with Plasmodium, the parasite that causes malaria.

21 Feb 2017

Listeria may pose severe risk of miscarriage in early stages of pregnancy

Listeria, a common food-borne bacterium, may pose a greater risk of miscarriage in the early stages of pregnancy than appreciated, according to researchers at the University of Wisconsin-Madison School of Veterinary Medicine studying how pathogens affect fetal development and change the outcome of pregnancy.

21 Feb 2017

Penn researchers find new way to track rare T cells in blood after annual flu vaccine

For most vaccines to work the body needs two cell types - B cells and T helper cells - to make antibodies. B cells are the antibody factories and the T helper cells refine the strength and accuracy of antibodies to home and attack their targets.

20 Feb 2017

HMS scientists listen to crosstalk between gut microbes and immune system

The human gut is home to some 100 trillion bacteria, comprising between 250 and 500 species. This astounding array of organisms, collectively known as the gut microbiome, is a powerful regulator of disease and health and has been implicated in conditions ranging from inflammatory bowel disease to multiple sclerosis.

16 Feb 2017

Glowing mice could mark major step forward for new gene therapy

Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would carry instructions for assembling the protein that makes fireflies light up and deliver them into the cells of an anesthetized mouse. If their technique worked, the mouse would glow in the dark.

16 Feb 2017

Salk scientists use mRNA to successfully treat hemophilia B in mice

FedEx, UPS, DHL--when it comes to sending packages, choices abound. But the most important delivery service you may not have heard of mRNA.

16 Feb 2017

Combination of drugs amplifies kill rates of brain cancer tumours in mice

A promising combination of immunotherapies delivers a one-two punch to brain cancer tumours with high cure rates in mice, scientific evidence published in Nature Communications today says.

15 Feb 2017

Salk professor receives inaugural Sjöberg Prize for groundbreaking cancer research

Salk Professor Tony Hunter, who holds an American Cancer Society Professorship, has been awarded $500,000 as part of the $1 million Royal Swedish Academy of Sciences' inaugural Sjöberg Prize for Cancer Research for "groundbreaking studies of cellular processes that have led to the development of new and effective cancer drugs."

14 Feb 2017

Immune Response News and Research

Researchers discover promising target for treatment of leishmaniasis

Scientists devise novel DNA vaccine approach against important cancer antigen targets

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

NSAIDs could potentially be repurposed as life-saving treatment for sepsis, research suggests

Study reveals mechanisms behind Zika transmission to fetus and adverse perinatal outcomes

Penn-led researchers gain better understanding of how T cells support long-lived plasma cells

Treating multiple myeloma with rabbit virus eliminates majority of malignant cells, study shows

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

Scientists explore role of salt and immune system in raising blood pressure of females

NIH launches new study to test experimental vaccine that targets mosquito-transmitted diseases

Investigational malaria vaccine protects against multiple strains, study shows

Danish research may pave way for immunological treatment of cancer

UofL researcher receives NIH grant to study microbes responsible for protecting against malaria

Listeria may pose severe risk of miscarriage in early stages of pregnancy

Penn researchers find new way to track rare T cells in blood after annual flu vaccine

HMS scientists listen to crosstalk between gut microbes and immune system

Glowing mice could mark major step forward for new gene therapy

Salk scientists use mRNA to successfully treat hemophilia B in mice

Combination of drugs amplifies kill rates of brain cancer tumours in mice

Salk professor receives inaugural Sjöberg Prize for groundbreaking cancer research

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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