Immune Response News and Research

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Study reveals direct regulatory role of serotonin in rheumatoid arthritis

For the first time, serotonin (5-hydroxytryptamine, 5-HT) has been directly implicated in the pathophysiology of rheumatoid arthritis (RA). Although 5-HT is predominantly known as a neurotransmitter within the central nervous system, new evidence points to additional important functions for serotonin in the periphery.

10 Mar 2016

HIV-positive individuals in Africa with certain genetic variant have lower chance of developing TB

In the first known discovery of its kind, a Case Western Reserve University School of Medicine-led team has found that HIV patients in Africa with a certain genetic variant have a 63-percent lower chance of developing tuberculosis than HIV patients without the genetic variant.

10 Mar 2016

Nociceptin could help to reduce effects of asthma attacks

An international team of researchers from the Universities of Leicester and Naples has examined the role of a receptor in the body that could help to prevent or reduce the effects of asthma attacks.

9 Mar 2016

Bonn scientists identify immune factor partially responsible for chronic viral infection

Many viral diseases tend to become chronic - including infections with the HI virus. In persons affected, the immune response is not sufficient to eliminate the virus permanently.

8 Mar 2016

Research could change the way people look at gene expression, immune response

Research from the Single-Cell Genomics Centre on the Wellcome Genome Campus could change the way we look at gene expression and immune response. Published in Nature Methods, the new method, TraCeR, provides a powerful tool for research into immune response, vaccination, cancer and autoimmunity.

8 Mar 2016

First atomic-scale view of interaction between HIV capsid and host protein cyclophilin A

A new study offers the first atomic-scale view of an interaction between the HIV capsid - the protein coat that shepherds HIV into the nucleus of human cells - and a host protein known as cyclophilin A. This interaction is key to HIV infection, researchers say.

7 Mar 2016

Research highlights association of western diet with Alzheimer's disease

Recent research has established associations between certain environmental factors, including eating a western diet and being sedentary, with an increased susceptibility to Alzheimer's disease. In fact, it is estimated that a combination of diet and inactivity contributes to as many as 25% of Alzheimer's cases. Nonetheless, little is known about the exact disease mechanisms and how or why this increasingly common middle-age lifestyle can play such a big role in subsequent cognitive function.

7 Mar 2016

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

A study of obesity and related metabolic changes on bladder cancer incidence and deaths, and a plan to use stem cells to grow novel urinary tubes are among 10 research projects awarded funding by the Johns Hopkins Greenberg Bladder Cancer Institute.

7 Mar 2016

Study highlights new approach to produce coral snake antivenom from synthetically designed DNA

Coral snake venom carries significant neurotoxicity and human injuries can be severe or even lethal. Despite this, antivenom treatments are scarce due to challenges collecting adequate amounts of venom needed to produce anti-elapidic serum. PLOS Neglected Tropical Diseases highlights exciting new research from the Butantan Institute in Brazil using synthetically designed DNA to produce coral-snake antivenom.

4 Mar 2016

Study identifies biomarker that plays role in early stages of Alzheimer's disease

A multicenter study led by Christian Haass and Michael Ewers of Ludwig-Maximilians-Universitaet in Munich has identified a biomarker associated with the activation of an innate immune response to neural damage during early stages of Alzheimer's disease.

4 Mar 2016

Means to target all tumor cells with one treatment uncovered

Research sponsored by Cancer Research UK has identified mutations common to all tumour cells. Immunotherapies specific for these mutations could deliver chemotherapeutic agents to all tumour cells and destroy them.

4 Mar 2016

Scientists track rare potent antibodies in HIV-infected individual

One of the most crucial and elusive goals of an effective HIV vaccine is to stimulate antibodies that can attack the virus even as it relentlessly mutates.

4 Mar 2016

Targeted Case Management has major impact on HIV-positive patients

Providing comprehensive, holistic case management to people dealing with multiple comorbid conditions, including HIV, can yield tangible health improvements and long-term cost savings, according to a new study released by Amida Care, a New York City nonprofit health plan, and ACRIA, an HIV/AIDS research organization.

2 Mar 2016

WRAIR researchers publish results from Plasmodium vivax malaria vaccine study

Walter Reed Army Institute of Research researchers recently published the results of testing a Plasmodium vivax malaria vaccine candidate in a human challenge model.

27 Feb 2016

Two investigational Ebola vaccines well-tolerated in Phase 2 clinical trial

Two investigational vaccines designed to protect against Ebola virus disease were well-tolerated and induced an immune response among 1,000 vaccinated participants in the Phase 2 randomized, placebo-controlled clinical trial called PREVAIL I.

25 Feb 2016

Research: Impaired immune response significantly involved in rare autoimmune diseases

In the context of the multicentre EU project "INTRICATE" under the management of Renate Kain of the Clinical Institute for Pathology of MedUni Vienna, the effects of infections on the generation of rare autoimmune diseases such as granulomatous polyangiitis (GPA), a systemic disease of the vascular system, are examined.

25 Feb 2016

New clinical trial launched to test potential drug that could help immune system combat cancer

Cancer Research UK's Centre for Drug Development, in partnership with Amgen Inc., has launched a new clinical trial to test a drug that could stop a patient's immune system from protecting tumours.

24 Feb 2016

DEK gene present in plasma can help predict outcomes for patients with head and neck cancer

Researchers at the University of Cincinnati have discovered that a human cancer-causing gene, called DEK, can be detected in the plasma of head and neck cancer patients. DEK may help doctors understand how a person's immune system could be used to treat cancer or predict outcomes for patients.

18 Feb 2016

Specialised white blood cell in birds can destroy fatal fungal infection

Scientists have discovered that a specialised white blood cell found in birds can destroy a potentially fatal fungal infection which affects more than one million people every year.

18 Feb 2016

Discovery could lead to more effective vaccines, personalised therapies for TB

Tuberculosis (TB) used to kill one in seven people around the world before the advent of antibiotics. However the increasing prevalence of multi-drug resistant TB means that doctors are running out of options in trying to combat this bacterium.

18 Feb 2016

Immune Response News and Research

Study reveals direct regulatory role of serotonin in rheumatoid arthritis

HIV-positive individuals in Africa with certain genetic variant have lower chance of developing TB

Nociceptin could help to reduce effects of asthma attacks

Bonn scientists identify immune factor partially responsible for chronic viral infection

Research could change the way people look at gene expression, immune response

First atomic-scale view of interaction between HIV capsid and host protein cyclophilin A

Research highlights association of western diet with Alzheimer's disease

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

Study highlights new approach to produce coral snake antivenom from synthetically designed DNA

Study identifies biomarker that plays role in early stages of Alzheimer's disease

Means to target all tumor cells with one treatment uncovered

Scientists track rare potent antibodies in HIV-infected individual

Targeted Case Management has major impact on HIV-positive patients

WRAIR researchers publish results from Plasmodium vivax malaria vaccine study

Two investigational Ebola vaccines well-tolerated in Phase 2 clinical trial

Research: Impaired immune response significantly involved in rare autoimmune diseases

New clinical trial launched to test potential drug that could help immune system combat cancer

DEK gene present in plasma can help predict outcomes for patients with head and neck cancer

Specialised white blood cell in birds can destroy fatal fungal infection

Discovery could lead to more effective vaccines, personalised therapies for TB

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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