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Neuroinvasiveness of SARS-CoV-2 shown by viral RNA and inflammation in the brain

A new study describes the results of a macaque study that showed the development of neurological features of inflammation, following infection by SARS-CoV-2.

25 Feb 2021

Researchers discover specific blood biomarker that predicts kidney transplant rejection

Researchers at the University of Pittsburgh School of Medicine have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene and prevent permanent damage.

25 Feb 2021

New diagnostic approach to evaluate the skin complications of diabetes mellitus

The multidisciplinary research team published their research "Skin complications of diabetes mellitus revealed by polarized hyperspectral imaging and machine learning" recently in the IEEE transactions on Medical imagining.

22 Feb 2021

FDA approves novel 3D-printed talus implant for humanitarian use

Today, the U.S. Food and Drug Administration approved the Patient Specific Talus Spacer 3D-printed talus implant for humanitarian use.

17 Feb 2021

Statins shown to reduce COVID-19 severity and lower mortality

Much attention has been focused on ways to reduce the deadly exaggeration of normal inflammatory reactions to this pathogen. A new research paper posted to the medRxiv* preprint server describes the alleviation of hyper-inflammatory phenomena following the administration of statins, drugs more widely known for their use in reducing blood cholesterol levels, to patients with COVID-19.

11 Feb 2021

Could Galectin-3 be a potential biomarker to help identify severe COVID-19 early?

Researchers have measured the galectin-3 levels in the sera of hospitalized patients. They found initial high levels indicate patients will become severely ill, suggesting it could be used as a predictor of severe disease.

10 Feb 2021

Novel immunotherapy approach to revert the main hallmarks of cat allergy

Researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) brought forward the potential of high doses of a specific adjuvant molecule, namely CpG oligonucleotide, in successfully modulating the immune system's allergic response to the main cat allergen Fel d 1, thereby inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy.

5 Feb 2021

Study may lead to new therapeutic strategies to reduce allergic responses, inflammatory reactions

In order to fight pathogens, mast cells regulate inflammatory reactions of the immune system. Both mast cells and neutrophils are white blood cells and are critical for the body's immune defense.

5 Feb 2021

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.

3 Feb 2021

Immune profiling shows differences in COVID-19 and influenza pathologic pathways

A study conducted at Johns Hopkins University School of Medicine in Baltimore has revealed distinct differences in the immune pathways that are activated by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and those that are activated by influenza.

2 Feb 2021

Lower diagnostic threshold for fever in older people may help detect COVID-19 cases earlier

Researchers have explored heritable factors, age and body mass on temperature variation between humans. One notable finding is that the current threshold for detecting fever in older adults may be too high, precluding the ability to detect COVID-19 early on

2 Feb 2021

Complication of severe SARS-CoV-2 pneumonia results in persistent cortical blindness: Case report

A study recently published in the journal Cureus has described a case report of a coronavirus disease 2019 (COVID-19) patient who presented with pneumonia, posterior reversible encephalopathy syndrome (PRES), and persistent cortical blindness. A detailed clinical presentation of the patient is provided in the report.

31 Jan 2021

Hyperinflammatory conditions drive gender differences in COVID-19 severity and mortality

Recently researchers from India analyzed gender differences in COVID-19-related hyperinflammatory conditions resulting in mortality in Indian patients. The study is published on the preprint server, medRxiv*.

25 Jan 2021

A traditional Chinese medicine could help treat COVID‐19 symptoms

A team of researchers in China – at Guangzhou University of Chinese Medicine and Yunnan University of Chinese Medicine – recently explored the therapeutic properties of Yinqiao powder in treating COVID-19 symptoms. Their findings were recently published in Phytotherapy Research.

22 Jan 2021

Eliminating key gene could revive exhausted immune cells to battle solid tumors

Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study led by UT Southwestern researchers suggests.

20 Jan 2021

Research suggests St. John's Wort and Echinacea could protect against COVID-19

Researchers in Saudi Arabia have conducted a study demonstrating the antiviral effects of two medicinal herbs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

17 Jan 2021

Simple blood test can predict which COVID-19 patients are at high risk of severe disease

One of the most vexing aspects of the COVID-19 pandemic is doctors' inability to predict which newly hospitalized patients will go on to develop severe disease, including complications that require the insertion of a breathing tube, kidney dialysis or other intensive care.

15 Jan 2021

Could Vitamin D be an effective adjuvant to help mitigate the COVID-19 pandemic?

As the coronavirus pandemic continues to wreak havoc across the globe, there is a dire need for effective and safe therapeutics and vaccines. Overall, the pandemic has infected more than 90.87 million people and taken more 1.94 million lives.

12 Jan 2021

ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

The cover for issue 45 of Oncotarget features Figure 3, "Representative images of whole tumor volume segmentation of the co-registered T1 post-contrast sequence and apparent diffusion coefficient (ADC) map, yielding the corresponding ADC histogram distribution utilized for data analysis," recently published in "Diffusion-weighted MR imaging histogram analysis in HIV positive and negative patients with primary central nervous system lymphoma as a predictor of outcome and tumor proliferation" by Khan, et al.