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Small and precise CRISPR-Cas13bt3 system can be used to shred viruses

Small and precise: These are the ideal characteristics for CRISPR systems, the Nobel-prize winning technology used to edit nucleic acids like RNA and DNA.

27 Sep 2023

Arrayed CRISPR Screening for Revolutionizing Target Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Kuenzel, Associate Director in the Functional Genomics department at AstraZeneca about the application of arrayed CRISPR screening for target identification and more.

From Society for Laboratory Automation and Screening (SLAS) 27 Sep 2023

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

Researchers evaluated sensitivity to immune checkpoint blockade (ICB) therapy.

20 Sep 2023

Research demonstrates a double-acting mechanism for fighting triple-negative breast cancer

Zachary Schug, Ph.D., assistant professor in the Molecular and Cellular Oncogenesis Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute, has published a new paper in the journal Nature Cancer.

19 Sep 2023

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Broken String Biosciences closes $15M series A funding round

Broken String Biosciences today announced that it has closed a $15 million Series A investment round.

From Broken String Biosciences 18 Sep 2023

Single-cell screening of cerebral organoids to identify developmental defects in autism

Researchers develop CRISPR-human organoids-single-cell RNA sequencing system to identify developmental brain defects in autism.

18 Sep 2023

NICER: A safer alternative to CRISPR/Cas9 for gene editing

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease.

15 Sep 2023

Researchers use machine learning to predict drug approval chances before clinical trials

Developing new drugs is paramount in discovering innovative treatments and preventing diseases. This is vital not only for advancing medicine but also for the overall health and well-being of humanity.

8 Sep 2023

Pitt neuroscientists create first non-human primate model of hereditary Alzheimer's in marmosets

To reimagine existing preclinical trials for Alzheimer's disease, University of Pittsburgh School of Medicine neuroscientists created the first non-human primate model of hereditary Alzheimer's in marmoset monkeys, outlining their approach in Alzheimer's & Dementia: Translational Research & Clinical Interventions.

6 Sep 2023

Stem cell gene therapy may offer a promising, curative treatment for sickle cell disease

New research published in the New England Journal of Medicine indicates that stem cell gene therapy may offer a promising, curative treatment for the painful, inherited blood disorder sickle cell disease (SCD).

30 Aug 2023

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Researchers evaluated the use of a dual clustered regularly interspaced short palindromic repeats (CRISPR)-Cas3 system.

29 Aug 2023

Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

A new study published in Nature Communications demonstrates how small molecule inhibitors can be used to improve the precision and efficiency of CRISPR-Cas9 gene editing.

25 Aug 2023

UC researchers study parasite that causes Chagas disease

Almost everything about insects called kissing bugs is revolting, from the insidious way they bite people's faces at night to drink their blood while they sleep to the way they spread disease through their poop.

23 Aug 2023

New gene therapy shows promise for treating fusion-driven cancers

A new study presents a promising treatment method for so-called fusion-driven cancers, which are currently often difficult to cure. These fusion-driven cancers are caused by an error in cell division that creates a fusion of different genes.

11 Aug 2023

Study identifies 135 genes associated with human skin color

The skin, hair and eye color of more than eight billion humans is determined by the light-absorbing pigment known as melanin.

11 Aug 2023

CRISPR/sgRNA-SAM therapy: a potential breakthrough for Parkinson's disease?

Researchers utilize the CRISPR-Cas9 system to induce the synthesis of dopamine (DA) in the brains of a rat model for Parkinson’s disease.

11 Aug 2023

Genome editing in the spotlight: genetic disorder carriers' views shape the conversation

Study explores perspectives on the applications of somatic genome editing.

8 Aug 2023

Can genome editing transform ocular disease treatment?

The discovery and development of gene-editing technologies and their applications in managing ocular diseases.

3 Aug 2023

New gene editing approach could revolutionize the treatment of blood disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

27 Jul 2023

Cas9 News and Research

Small and precise CRISPR-Cas13bt3 system can be used to shred viruses

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Subclonal neoantigens present a key roadblock in MMRd tumor immunotherapy success

Research demonstrates a double-acting mechanism for fighting triple-negative breast cancer

Researchers identify a rare cause of male infertility and discover a potential cure

Broken String Biosciences closes $15M series A funding round

Single-cell screening of cerebral organoids to identify developmental defects in autism

NICER: A safer alternative to CRISPR/Cas9 for gene editing

Researchers use machine learning to predict drug approval chances before clinical trials

Pitt neuroscientists create first non-human primate model of hereditary Alzheimer's in marmosets

Stem cell gene therapy may offer a promising, curative treatment for sickle cell disease

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

UC researchers study parasite that causes Chagas disease

New gene therapy shows promise for treating fusion-driven cancers

Study identifies 135 genes associated with human skin color

CRISPR/sgRNA-SAM therapy: a potential breakthrough for Parkinson's disease?

Genome editing in the spotlight: genetic disorder carriers' views shape the conversation

Can genome editing transform ocular disease treatment?

New gene editing approach could revolutionize the treatment of blood disorders

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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