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Study shows SARS-CoV-2 breakthrough infections fewer among fully vaccinated

A team of researchers at Indiana University reports genomic evidence of breakthrough infections in fully vaccinated individuals. The study, posted to the pre-print server medRxiv*, suggests that fully vaccinated individuals, including those with asymptomatic infections, are less likely to serve as a source of infection for others.

30 Jun 2021

Alpha (B.1.1.7) SARS-CoV-2 variant associated with more severe disease in hospitalized women

Researchers in the UK have conducted a study showing that infection with the B.1.1.7 (Alpha) lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be associated with an increased risk of death or intensive care unit (ITU) admission among women, compared with non-B.1.1.7 infection.

29 Jun 2021

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Researchers in the UK have warned that a widespread mutation that has arisen in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to escape recognition by CD8 T-cell responses in both convalescent patients and recipients of the current coronavirus disease 2019 (COVID-19) vaccines.

29 Jun 2021

Researchers show how Covid-19 changes the size and stiffness of red and white blood cells

Using real-time deformability cytometry, researchers at the Max-Planck-Zentrum für Physik und Medizin in Erlangen were able to show for the first time: Covid-19 significantly changes the size and stiffness of red and white blood cells - sometimes over months.

29 Jun 2021

IU School of Medicine wins $30 million NIA funding to study Alzheimer’s disease and related dementias

National Centralized Repository for Alzheimer's Disease and Related Dementias grant has been renewed for another five years with funding expected to total $30 million from the National Institute on Aging (NIA), within the National Institutes of the Health.

29 Jun 2021

More evidence that mixing COVID-19 vaccines may help elicit a robust immune response

Eight volunteers who received a complete dose or a single dose of an mRNA vaccine or the ChAdOx1 vaccine after a dose of a trial gorilla adenovirus vaccine showed a significantly high level of antibodies and T cell response against SARS-CoV-2.

29 Jun 2021

Study offers more evidence that face masks can prevent SARS-CoV-2 transmission

A new study released as a preprint on the medRxiv* server suggests that the use of face masks, of various designs, successfully prevents SARS-CoV-2 transmission. This supports the continued implementation of mask policies in public places until herd immunity is achieved in the region involved.

29 Jun 2021

How is Taiwan tackling its third wave of COVID-19?

The international community has been struggling to predict and contain successive waves of the COVID-19 pandemic, caused by the novel SARS-CoV-2 pathogen. The degree of success has varied between countries. In Taiwan, the use of contact tracing, with testing and isolation of confirmed cases, promises to end the ongoing third wave of the illness within two months. The strategy employed is described in a new preprint available on the medRxiv* server.

29 Jun 2021

The technology behind face masks that can diagnose COVID-19

Researchers have recently incorporated technology into standard face masks to detect the presence of SARS-CoV-2.

29 Jun 2021

Cationic peptides inhibit SARS-CoV-2 cell entry

In a paper recently published in Pathogens, in silico affinity studies by researchers at the University of Illinois, USA, reveal several potential peptide binding sites required for HS-spike protein and ACE2-spike protein bond formation, and synthesis of suitable peptide inhibitors reveals impaired SARS-CoV-2 cell entry.

29 Jun 2021

Early testing can help mitigate blood clots related to AstraZeneca/Oxford vaccine

New research has shown that early testing for blood clots in patients who had received the AstraZeneca/Oxford vaccine led to them being treated successfully, highlighting the need for heightened awareness of the risk among doctors.

29 Jun 2021

Nanotechnology and the fight against COVID-19

In a review paper published in the open-access MDPI journal Viruses, a team of researchers explored the potential of nanotechnology to alleviate the current and future coronavirus burden. The team focused on its potential role in the detection, diagnosis, protection, and treatment of SARS-CoV-2 infection.

29 Jun 2021

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

Researchers from Canada recently presented an efficient strategy for recombinant production of enzymatically active TMPRSS2 ectodomain, enabling enzymatic characterization and the 1.95 Å X-ray crystal structure. Their work is published on the bioRxiv* preprint server while awaiting peer-review.

29 Jun 2021

Tackling emerging SARS-CoV-2 variants

An international team of authors has published a special report in The New England Journal of Medicine titled 'SARS-CoV-2 Variants and Vaccines’, which presents global strategies for the possible escape from vaccine-elicited immunity.

29 Jun 2021

UPMC expert finds successful treatment for rare diseases diagnosed by newborn screenings

1It was a nagging mystery: A rare-disease expert at UPMC Children's Hospital of Pittsburgh had found a successful treatment for two of the deadliest symptoms of one of the more common classes of rare diseases diagnosed by newborn screenings, but one symptom--painful episodes of muscle breakdown that land victims in intensive care--persisted.

29 Jun 2021

Wayne State awarded NSF grant to investigate how viruses navigate through the mucus barrier

A research team at Wayne State University led by Ashis Mukhopadhyay, Ph.D., associate professor of physics and astronomy in the College of Liberal Arts and Sciences, received a three-year, $326,226 grant from the National Science Foundation to investigate fundamental issues related to the passage of viruses through the mucus barrier.

29 Jun 2021

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Scientists from the Netherlands and the US recently studied the localization of the SARS-CoV-2 proteins in postmortem lung tissues of COVID-19 patients and in SARS-CoV-2 infected Vero cells that were processed identically. The research is posted to the bioRxiv* preprint server, prior to peer review.

29 Jun 2021

Acidic environment enhances production of butyric acid from apple pectin by fecal microbiota

Researchers from Tallinn University of Technology, Grete Raba, Signe Adamberg, and Kaarel Adamberg showed that an acidic environment enhances the production of butyric acid from apple pectin by fecal bacterial consortia - microbiota.

29 Jun 2021

SARS-CoV-2 test in 20 minutes with FISH

A collaboration from the University of Oxford and the University of Warwick has led to research into a novel method of viral detection through rapid fluorescence in situ hybridization (FISH) in order to effectively detect the SARS-CoV-2 virus within 20 minutes.

29 Jun 2021

Differences in monocyte subsets between severe COVID-19 and long COVID

Researchers in the United States and Costa Rica have identified differences in the proportions of monocyte subsets that occur in severe cases of coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and post-acute sequelae of COVID-19 (PASC), often referred to as “Long COVID”.

28 Jun 2021

Syndrome News and Research

Study shows SARS-CoV-2 breakthrough infections fewer among fully vaccinated

Alpha (B.1.1.7) SARS-CoV-2 variant associated with more severe disease in hospitalized women

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Researchers show how Covid-19 changes the size and stiffness of red and white blood cells

IU School of Medicine wins $30 million NIA funding to study Alzheimer’s disease and related dementias

More evidence that mixing COVID-19 vaccines may help elicit a robust immune response

Study offers more evidence that face masks can prevent SARS-CoV-2 transmission

How is Taiwan tackling its third wave of COVID-19?

The technology behind face masks that can diagnose COVID-19

Cationic peptides inhibit SARS-CoV-2 cell entry

Early testing can help mitigate blood clots related to AstraZeneca/Oxford vaccine

Nanotechnology and the fight against COVID-19

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

Tackling emerging SARS-CoV-2 variants

UPMC expert finds successful treatment for rare diseases diagnosed by newborn screenings

Wayne State awarded NSF grant to investigate how viruses navigate through the mucus barrier

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Acidic environment enhances production of butyric acid from apple pectin by fecal microbiota

SARS-CoV-2 test in 20 minutes with FISH

Differences in monocyte subsets between severe COVID-19 and long COVID

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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