Phenotype News and Research

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Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

To establish a molecular signature of this resistance in ovarian cancer, the authors developed preclinical tumor models of adaptive resistance to chronic anti-VEGF treatment.

8 Jan 2020

Dog study suggests that AAV in gene therapy could induce cancer

A gene therapy study in dogs has stirred up old fears that by using AAV in gene therapy, it may be increasing cancer chances.

8 Jan 2020

Study on chimpanzees shows maternal presence, maternal social status can impact offspring

The prolonged periods of juvenility and nutritional dependence that are characteristic of human development are thought to facilitate brain and somatic growth in children, as well as provide opportunities to learn and accumulate skills required for a productive adult life. In chimpanzees, the benefits of continuing to associate with mothers after becoming nutritionally independent are less well understood.

7 Jan 2020

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

It seems that chewing gum is not a new trend! Researchers have found chewing gum that is 5,700 years old and it has provided clues regarding ancient DNA. A study with the findings was published in the journal Nature Communications. It is titled, “A 5,700-year-old human genome and oral microbiome from chewed birch pitch.”

18 Dec 2019

Social and visual neural networks do not connect in some children with autism

Among the first and most-documented symptoms of autism spectrum disorder is a child's aversion to interaction with others. Specifically, they appear uninterested in social activities and stimuli that would normally attract a young child's attention, such as watching other children play, sing or dance.

17 Dec 2019

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

Researchers from The University of Texas MD Anderson Cancer Center today reported results from a pooled analysis of more than 5,100 breast cancer patients that found residual cancer burden continuous index and classification were independently and strongly prognostic for all breast cancer phenotypes.

13 Dec 2019

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, healthier lives. Unfortunately, cancer immunology therapy only works in a subset of patients.

9 Dec 2019

Kanazawa University researchers describe genetic typing of Pseudomonas putida

Pseudomonas putida is a bacterium occuring in soil, aquatic environments and plants. Although the virulence of Pseudomonas p. -- the ability of the bacterium to infect its host and inflict a disease -- is considered to be low, infection in severely ill patients can be lethal. P. putida strains (also called isolates) have been found in hospitals, e.g. in urine, blood or wound discharge from patients, and such clinical isolates have been found to display resistance to drugs.

6 Dec 2019

NeutroCure project aims to cure inflammatory disease with neutrophils

Curing disease with neutrophils; this is the goal of the NeutroCure project. How will that work? "Neutrophils have a yin yang character," explained Andrés Hidalgo, whose team at the Centro Nacional de Investigaciones Cardiovasculares is one of six member groups participating in this project coordinated by Andriy Mokhir Friedrich from Alexander University, Germany.

5 Dec 2019

Researchers identify key protein required for therapeutic resistance in aggressive breast cancer

Researchers at the Lady Davis Institute have identified a key protein that is required for resistance to chemotherapy in the most aggressive form of breast cancer. This holds the promise of opening the door to new therapies for overcoming drug resistance.

2 Dec 2019

Daughters of women with PCOS five times more likely to develop the syndrome in adulthood

Daughters of women with polycystic ovarian syndrome are five times more likely to be diagnosed with PCOS as adults, and the generational transmission is driven by high androgen levels during pregnancy, researchers at Karolinska Institutet in Sweden report.

2 Dec 2019

New molecular mechanism involved in the regulation of cholesterol movement in cells found

Researchers from the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute found a new molecular mechanism involved in the regulation of the cholesterol movement in cells, an essential process for a proper cell functioning.

2 Dec 2019

Exploring the link between macular degeneration and retinitis pigmentosa

Four words you never want to hear from the eye doctor are retinitis pigmentosa and macular degeneration.

25 Nov 2019

FDA-approved drug to prevent organ rejection may slow skin aging

The search for youthfulness typically turns to lotions, supplements, serums and diets, but there may soon be a new option joining the fray.

25 Nov 2019

Using AI to determine which lung cancer patients will benefit from immunotherapy

Scientists from the Case Western Reserve University digital imaging lab, already pioneering the use of Artificial Intelligence to predict whether chemotherapy will be successful, can now determine which lung-cancer patients will benefit from expensive immunotherapy.

23 Nov 2019

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Charitharth Vivek Lal, M.D., and University of Alabama at Birmingham colleagues have used a novel and first-of-its-kind newborn mouse model to study the effect of high oxygen concentrations, or hyperoxia, on lung development of newborn mice that are germ-free -- meaning no microbes colonizing their lungs.

21 Nov 2019

Research team publishes findings from study of TAF1 syndrome

An international, multidisciplinary research team from more than 50 institutions, led by geneticist and psychiatrist Gholson Lyon, MD, PhD, of the New York State Office for People With Developmental Disabilities' Institute for Basic Research in Developmental Disabilities, today announced publication of findings from its study of the rare disease TAF1 syndrome.

21 Nov 2019

Study: 15,000 cases of hypophosphatasia potentially undetected in Spanish population

Hypophosphatasia (HPP) is a rare and serious hereditary disease that is potentially life-threatening and is caused by one or more mutations in the gene coding for alkaline phosphatase (ALPL). It is frequently misdiagnosed.

15 Nov 2019

Addictive online shopping prevalent among treatment-seeking patients with BSD

A new study in Comprehensive Psychiatry, published by Elsevier, found that one third of a group of patients seeking treatment for buying-shopping disorder also reported symptoms of addictive online shopping.

14 Nov 2019

Altering malarial parasite genes to prevent malaria

Malaria is a mosquito-borne disease caused by the parasitic organism called Plasmodium, of which there are several types that cause the different kinds of malarial fever. This age-old infection still kills over 400,000 people every year, all over the world. A new study published in the journal Cell on November 14, 2019, shows how a simple tweaking of the genes of this organism could quite conceivably lead to the elimination of this disease altogether.

14 Nov 2019

Phenotype News and Research

Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

Dog study suggests that AAV in gene therapy could induce cancer

Study on chimpanzees shows maternal presence, maternal social status can impact offspring

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

Social and visual neural networks do not connect in some children with autism

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Kanazawa University researchers describe genetic typing of Pseudomonas putida

NeutroCure project aims to cure inflammatory disease with neutrophils

Researchers identify key protein required for therapeutic resistance in aggressive breast cancer

Daughters of women with PCOS five times more likely to develop the syndrome in adulthood

New molecular mechanism involved in the regulation of cholesterol movement in cells found

Exploring the link between macular degeneration and retinitis pigmentosa

FDA-approved drug to prevent organ rejection may slow skin aging

Using AI to determine which lung cancer patients will benefit from immunotherapy

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Research team publishes findings from study of TAF1 syndrome

Study: 15,000 cases of hypophosphatasia potentially undetected in Spanish population

Addictive online shopping prevalent among treatment-seeking patients with BSD

Altering malarial parasite genes to prevent malaria

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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