CLARITY News and Research

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The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.

MIT researchers develop novel method for multiscale imaging of the brain tissue

MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to peer at molecules within cells or take a wider view of the long-range connections between neurons.

27 Jul 2016

Neutrons key to discovering new HIV drugs? An interview with Dr Matthew Blakeley

Neutron crystallography allows us to determine the three-dimensional structures of biological macromolecules, such as proteins, by means of the diffraction of neutrons from the regularly spaced atoms of a crystal.

21 Jul 2016

Experts propose guidelines to offer clarity for disputes over frozen embryos

In at least 11 cases over the last 24 years, including the appeal of a Missouri case heard in June, U.S. courts have grappled with difficult arguments between men and women who fertilized and froze embryos together, but then disagreed about whether they should be gestated and born.

19 Jul 2016

AHSN already working to tackle sepsis across North East and North Cumbria

Doctors and nurses in the region have been working collaboratively for over a year to ensure the effective recognition and response to sepsis.

14 Jul 2016

Researchers identify new mechanism by which bacteria outsmarts immune system

Bacteria are rapidly developing resistance mechanisms to combat even the most effective antibiotics.

13 Jul 2016

New report reveals lack of attention in implementing government recommendations on end of life care

On the same day as the Government will respond to the Review into Choice at the End of Life, a new report reveals that, despite an abundance of government recommendations on end of life care in England, not enough attention has been given to how policies are implemented and there is uncertainty in terms of whether they have actually led to improvements in patient care.

6 Jul 2016

University report explores efficacy of palliative care in England

A new report by Sheffield Hallam University has revealed that, despite an abundance of government recommendations on end of life care in England, there is uncertainty as to whether they have led to improvements in patient care.

From Sheffield Hallam University 6 Jul 2016

Two vaccine candidates provide complete protection against ZIKV infection in mice

The rapid development of a safe and effective vaccine to prevent the Zika virus (ZIKV) is a global priority, as infection in pregnant women has been shown to lead to fetal microcephaly and other major birth defects.

29 Jun 2016

Experts develop set of resolutions, conclusions to provide clarity on testosterone therapy

In an effort to address widespread concerns related to testosterone deficiency (TD) and its treatment with testosterone therapy, a group of international experts has developed a set of resolutions and conclusions to provide clarity for physicians and patients.

21 Jun 2016

Complex 36-point therapeutic personalized program can help reverse memory loss in early AD patients

Results from quantitative MRI and neuropsychological testing show unprecedented improvements in ten patients with early Alzheimer's disease (AD) or its precursors following treatment with a programmatic and personalized therapy. Results from an approach dubbed metabolic enhancement for neurodegeneration are now available online in the journal Aging.

16 Jun 2016

BRCA gene mutations raise risk of breast, ovarian and other cancers

BRCA Share, a public-private BRCA gene datashare initiative, today announced the public release of a large collection of new data on genetic variants in the BRCA1 and BRCA2 genes.

From Quest Diagnostics 2 Jun 2016

Study finds gap in screening for lipid abnormalities among adults taking antipsychotic medications

Too few adults taking antipsychotic medications are being screened for abnormalities in lipids, which include cholesterol and triglycerides, new research from the University of Colorado Anschutz Medical Campus finds.

25 May 2016

US swimming pool inspections provide worrying statistics

A recent report by Centers for Disease Control (CDC) says that 80% of inspections of public aquatic venues in the United States found at least one violation of safety standards. Immediate closure is enforced on thousands of public pools, hot tubs, and water playgrounds in the US every year as a result of safety concerns.

20 May 2016

Researchers use high-power prisms to design new eyeglasses to expand visual fields of hemianopia patients

Researchers from the Schepens Eye Research Institute of Massachusetts Eye and Ear and Harvard Medical School have designed three new eyeglasses using high-power prisms to optimally expand the visual fields of patients with hemianopia, a condition in which the visual fields of both eyes are cut by half.

18 May 2016

Study provides vital information regarding four diagnostic PD-L1 assays

A pre-competitive consortia of pharmaceutical companies, diagnostic companies, and academic associations, including the International Association for the Study of Lung Cancer, announced phase I results of the "BLUEPRINT PD-L1 IHC ASSAY COMPARISON PROJECT" at the Annual Meeting of the American Association for Cancer Research on April 19.

6 May 2016

Pioneering gene therapy may lead to potential cure for common causes of vision loss

Pioneering gene therapy has restored some vision to patients with a rare form of genetic blindness for as long as four years, raising hopes it could be used to cure common causes of vision loss, new University of Oxford research published today shows.

29 Apr 2016

Why don’t MS patients always engage with specialists? An interview with Dr Anita Rose

The recent survey you ask about was conducted by the MS Trust in 2012. It revealed that nearly one fifth of respondents had seen neither an MS specialist nurse (MSSN) nor a neurologist in the past year, and so will not have received the comprehensive annual review recommended by the National Institute for Health and Care Excellence (NICE).

25 Apr 2016

Caltech researchers map out pathways of neurons responsible for Parkinson's motor impairments

Because billions of neurons are packed into our brain, the neuronal circuits that are responsible for controlling our behaviors are by necessity highly intermingled. This tangled web makes it complicated for scientists to determine exactly which circuits do what. Now, using two laboratory techniques pioneered in part at Caltech, Caltech researchers have mapped out the pathways of a set of neurons responsible for the kinds of motor impairments--such as difficulty walking--found in patients with Parkinson's disease.

21 Apr 2016

New consensus statement guides student-athletes to respond to sudden cardiac arrest

The Journal of the American College of Cardiology today published a consensus statement that establishes guidance for conducting pre-participation screenings of college athletes and encourages emergency action plans for quickly responding to sudden cardiac arrest.

16 Apr 2016

New test can detect early stages of sight loss in age-related macular degeneration

Researchers based at the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at Moorfields Eye Hospital and UCL Institute of Ophthalmology, received funding from Fight for Sight and the Special Trustees of Moorfields Eye Hospital NHS Foundation Trust which has resulted in the design of a new test that can spot the first stages of sight loss in age-related macular degeneration (AMD).

30 Mar 2016