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Study offers insights into genetic factors that affect immunological responses in type 1 diabetes

New insights into how genetic factors affect the body's immune response in type 1 diabetes have been published in eLife.

7 Jun 2022

Phase separation discovery could lead to new interventions to regulate immune activity

Protein complexes that play a critical role in launching an immune response assemble in droplets that form within the liquid environment in cells much like oil droplets in water, UT Southwestern scientists report in a new study.

6 Jun 2022

Link between COVID-19 severity and microbiome of saliva and nasopharynx

In a recent study posted to the bioRxiv* preprint server, researchers profiled the salivary and nasopharyngeal microbiomes of coronavirus disease 2019 (COVID-19) patients and determined the association between the microbiomes and COVID-19 severity.

6 Jun 2022

New immunotherapy mechanism can block spontaneous breast carcinogenesis

Researchers have discovered the mechanism by which specific immune cells can block breast cancer development and even suppress a developed tumor.

3 Jun 2022

Immune responses may exist on a finer spectrum than previously believed

Researchers from McGill University and the US National Cancer Institute (NCI) have made some surprising discoveries about our immune system.

3 Jun 2022

Study finds long-term exposure to common air pollutants is associated with COVID-19 severity

Researchers evaluate the relationship between long-term exposure to three common air pollutants and key indicators of COVID-19 severity.

30 May 2022

Neurological symptoms may persist for over one year in long-COVID patients

Patients who have recovered from COVID-19 are likely to experience persistent neurologic symptoms for a median of 14.8 months following their initial infection.

30 May 2022

Study finds TGF-β2 associated with asymptomatic mild SARS-CoV-2 infection during pregnancy

A new study investigated the clinical and obstetric outcomes after SARS-CoV-2 infection in two groups of pregnant women, along with their association with the immunological parameters.

28 May 2022

New approach could treat brain tumors and also prevent or delay recurrences

Scientists at the University of Michigan Rogel Cancer Center were optimistic when they identified a small molecule that blocked a key pathway in brain tumors.

27 May 2022

Scientists discover a gene defect that results in allergic and autoimmune disease

Inflammation of the skin and the esophagus, food allergy and asthma are just some of the symptoms of a now 12-year-old boy who was the first to have a mutation on the IL-33 gene. An international team led by a physician from the Karl Landsteiner University for Health Sciences, Krems, discovered this new disease entity.

26 May 2022

HKUMed researchers report the effects of SARS-CoV-2 on bone metabolism

A research team led by Professor Kelvin Yeung Wai-kwok and Dr Jasper Chan Fuk-woo from the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered that SARS-CoV-2 infection can cause inflammatory activation of bone resorption cells, leading to severe bone loss during the acute and post-recovery phases of COVID-19.

25 May 2022

Immunogenicity of BNT162b2 COVID-19 vaccine in melanoma patients receiving immunotherapy

In a recent study under review at the Scientific Reports journal and posted to the Research Square* preprint server, researchers evaluated the efficacy of messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine BNT162b2 in cancer patients under treatment with immune checkpoint inhibitors (ICIs).

25 May 2022

Serological biomarker predicts severe Crohn's disease seven years prior to diagnosis

An international team led by a University of Toronto researcher has found that an antibody detectable in blood predicts severe Crohn's disease and is detectable up to seven years prior to disease diagnosis.

24 May 2022

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

In a recent study posted to the medRxiv* preprint server, investigators in Singapore showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection elicited broadly specific virus-selective nasal resident CD8 and CD4 T cells.

24 May 2022

Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

A new study investigated whether a specific population of local Bmem cells in the proximal LNs produce secondary GC responses that are different from those at distal sites and if the location in humoral immunity is relevant only to nonlymphoid tissues.

23 May 2022

Anti-SARS-CoV-2 titers predict COVID severity

A recent study published in the journal Viruses reported that antibody titers against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could serve as a marker for the severity of coronavirus disease 2019 (COVID-19).

22 May 2022

Olverembatinib a potent inhibitor of Omicron NTD-mediated cytokine release

Researchers determine whether mutations in the Omicron NTD influence its potential to stimulate myeloid cells and enhance inflammatory cytokine release.

22 May 2022

Study reveals how ZBP1 could lead to a cytokine storm during COVID-19

Scientists from St. Jude Children's Research Hospital have shown that the innate immune sensor, ZBP1, and its associated inflammatory cell death pathway, PANoptosis, are major contributors to the negative effects of interferon treatment and high interferon levels in some COVID-19 patients.

20 May 2022

Research provides new insight into how Crimean-Congo hemorrhagic fever virus causes disease

Army scientists determined that the body's own natural immune response contributes to disease severity in mice infected with Crimean-Congo hemorrhagic fever virus (CCHFV), which causes a widespread tick-borne viral infection in humans.

20 May 2022

Molecular target discovery opens new pathways for developing effective anti-angiogenic cancer therapy

Researchers with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have identified a new molecular drug target that could result in new cancer drugs with fewer side effects.

20 May 2022

Cytokine News and Research

Study offers insights into genetic factors that affect immunological responses in type 1 diabetes

Phase separation discovery could lead to new interventions to regulate immune activity

Link between COVID-19 severity and microbiome of saliva and nasopharynx

New immunotherapy mechanism can block spontaneous breast carcinogenesis

Immune responses may exist on a finer spectrum than previously believed

Study finds long-term exposure to common air pollutants is associated with COVID-19 severity

Neurological symptoms may persist for over one year in long-COVID patients

Study finds TGF-β2 associated with asymptomatic mild SARS-CoV-2 infection during pregnancy

New approach could treat brain tumors and also prevent or delay recurrences

Scientists discover a gene defect that results in allergic and autoimmune disease

HKUMed researchers report the effects of SARS-CoV-2 on bone metabolism

Immunogenicity of BNT162b2 COVID-19 vaccine in melanoma patients receiving immunotherapy

Serological biomarker predicts severe Crohn's disease seven years prior to diagnosis

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

Anti-SARS-CoV-2 titers predict COVID severity

Olverembatinib a potent inhibitor of Omicron NTD-mediated cytokine release

Study reveals how ZBP1 could lead to a cytokine storm during COVID-19

Research provides new insight into how Crimean-Congo hemorrhagic fever virus causes disease

Molecular target discovery opens new pathways for developing effective anti-angiogenic cancer therapy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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