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DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13th in the open access journal PLOS Biology by Madison Strine and Craig Wilen of Yale University, US, and colleagues.

13 Jun 2023

Study illuminates how T cells fight and remember infections

The immune system protects the body from invaders, such as bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs.

13 Jun 2023

Study provides a new and promising strategy for future cancer immunotherapies

CD8+ T cells, a vital component of the immune system that provides immunity against cancer, have been the focal point of anti-cancer therapies.

13 Jun 2023

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Researchers evaluated the therapeutic efficacy of Navoximod.

13 Jun 2023

The battle against avian influenza: genetic analysis unveils the origins of H5N1 outbreak

Researchers analyzed epidemiologic and phylogeographic characteristics of the avian influenza virus.

13 Jun 2023

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair."

13 Jun 2023

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

Researchers at Georgetown University's Lombardi Comprehensive Cancer Center and colleagues who have been exploring the complexities of biochemical pathways involved in cancer development have found that a form of glucose, a type of sugar, is intricately linked to a pathway used to build DNA molecules.

12 Jun 2023

Study reveals how p62 bodies control redox-independent stress response

Cellular stress, or oxidative stress, occurs when there is a buildup of reactive oxygen species (ROS), which interferes with cellular mechanisms and can even cause damage to proteins, lipids, and DNA.

12 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

Shifting towards precision medicine for type 2 diabetes dietary management

Researchers reviewed existing data on the genetic factors and the gene-diet interactions that could alter dietary management of type 2 diabetes.

8 Jun 2023

Study compares long-term consequences of COVID-19 between patients with rheumatic inflammatory diseases and healthy controls

Researchers used data from a long-term ongoing prospective cohort study in the Netherlands to compare the characteristics of long-COVID in inflammatory rheumatic diseases patients and healthy controls during the period when the SARS-CoV-2 Omicron subvariants, BA.1/BA.2 were dominant.

8 Jun 2023

New insights into how aggressive cancer cells proliferate and propagate the disease

Not all cancer metastases have the same destructive effect. Researchers demonstrate different mechanisms in experiments.

7 Jun 2023

Is discontinuing universal SARS-CoV-2 testing at hospital admission in England and Scotland associated with increased hospital-onset infections?

Researchers performed a time series analysis using public data sets from both nations to examine whether this discontinuation resulted in a surge in hospital-onset COVID-19 cases.

7 Jun 2023

Transcription News and Research

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Study illuminates how T cells fight and remember infections

Study provides a new and promising strategy for future cancer immunotherapies

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

The battle against avian influenza: genetic analysis unveils the origins of H5N1 outbreak

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

Study reveals how p62 bodies control redox-independent stress response

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Shifting towards precision medicine for type 2 diabetes dietary management

Study compares long-term consequences of COVID-19 between patients with rheumatic inflammatory diseases and healthy controls

New insights into how aggressive cancer cells proliferate and propagate the disease

Is discontinuing universal SARS-CoV-2 testing at hospital admission in England and Scotland associated with increased hospital-onset infections?

Experts investigate the correlation between BORIS mutations and protein expression

How lipid metabolites in the gut aid in regulatory T-cell differentiation

Groundbreaking study maps molecular architecture of the visual system's integral components

How does a riboswitch regulate its own synthesis?

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

Green Mediterranean diet reshapes DNA methylation, boosts metabolism

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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