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Biological “feed-forward” loop contributes to progression of osteoarthritis

An unfortunate biological "feed-forward" loop drives cartilage cells in an arthritic joint to actually contribute to progression of the disease, say researchers at Duke University and Washington University in Saint Louis.

23 Mar 2021

New review of post-acute COVID-19

The first year of the COVID-19 pandemic has taken the lives of millions of people around the world but has also left hundreds with lingering symptoms or completely new symptoms weeks after recovery.

23 Mar 2021

New technique may result in earlier and easier identification of patients with Barrett's esophagus

A new technique for sampling and testing cells from Barrett's esophagus (BE) patients could result in earlier and easier identification of patients whose disease has progressed toward cancer or whose disease is at high risk of progressing toward cancer, according to a collaborative study by investigators at Case Western Reserve University and Johns Hopkins Kimmel Cancer Center (JHKCC).

23 Mar 2021

Biological feed-forward loop drives cartilage cells in an arthritic joint to contribute to progression of the disease

23 Mar 2021

Non-invasive scTS improves handgrip strength, motor control in people with complete tetraplegia

Kessler Foundation researchers demonstrated that spinal cord transcutaneous stimulation (scTS) combined with hand training improves upper extremity and hand function in individuals with motor and sensory compete spinal cord injury (SCI).

22 Mar 2021

Study identifies metabolic processes associated with multiple, unrelated diseases

Many older, but also increasingly younger, people suffer from several diseases at the same time. Scientists at the Berlin Institute of Health at Charité – Universitätsmedizin Berlin, together with colleagues from Munich and the United Kingdom, have now identified common risk factors that predispose to multiple even seemingly unrelated diseases.

22 Mar 2021

New method could drive down the production cost of antibodies

Antibody injections are a highly desirable treatment for people with chronic diseases such as cancer, psoriasis, Crohn's disease and arthritis. And recently, antibodies have been in the news as a promising treatment for severe cases of COVID-19.

22 Mar 2021

SARS-CoV-2 infection is circadian

An international team of researchers has found that angiotensin-converting enzyme 2 (ACE2) levels in lung cells vary over the day, affecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The virus entry and replication in the lung cells also have a rhythmic cycle, suggesting circadian processes can affect the virus's life cycle.

22 Mar 2021

Disease-driving B cells play a role in the development of NAFLD

New research from the University of Minnesota Medical School suggests that disease-driving B cells, a white blood cell, play a role in the development of non-alcoholic fatty liver disease (NAFLD) - the most common chronic liver condition in the U.S.

22 Mar 2021

Study: Early benefit assessment of new drugs within the framework of AM-NOG procedure

"The AMNOG procedure has passed its first practical test. It is practicable and can also be implemented in detail", emphasized IQWiG's Director Jürgen Windeler in October 2011, when the Institute had published its first early benefit assessment within the framework of the AM-NOG procedure (AMNOG = Act on the Reform of the Market for Medicinal Products).

22 Mar 2021

Stress-free life may lead to lower cognitive function

Stress is a universal human experience that almost everyone deals with from time to time. But a new study found that not only do some people report feeling no stress at all, but that there may be downsides to not experiencing stress.

22 Mar 2021

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

Researchers at the University of Hong Kong found that Clofazimine, a lipophilic antimicrobial riminophenazine dye used in combination with agents like rifampicin and dapsone to treat leprosy, inhibits coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease.

21 Mar 2021

Study maps structure and mechanism of a membrane enzyme that plays role in inflammation, cancer

Most drugs operate via the membranes that surround the body's cells. A study by researchers at Karolinska Institutet in Sweden has now mapped the structure and mechanism of MGST2, a membrane enzyme that, amongst other things, plays a part in chronic inflammation and cancer.

20 Mar 2021

$11 million COBRE funding will help create Center for Pre-Clinical Cancer Research at LSU SVM

The Louisiana State University School of Veterinary Medicine, or LSU SVM, has received an $11 million grant to establish a Center of Biomedical Research Excellence, or COBRE.

19 Mar 2021

VR offers hope to nerve injury patients experiencing chronic pain

We all feel physical pain in different ways, but people with nerve injuries often have a dysfunctional pain suppression system, making them particularly prone to discomfort.

19 Mar 2021

Study reveals worsening health profiles in Gen X and Gen Y

Recent generations show a worrying decline in health compared to their parents and grandparents when they were the same age, a new national study reveals.

19 Mar 2021

Doctors found jet fuel in veteran’s lungs. He can’t get full benefits.

The lungs Bill Thompson was born with told a gruesome, harrowing and unmistakable tale to Dr. Anthony Szema when he analyzed them and found the black spots, scarring, partially combusted jet fuel and metal inside.

19 Mar 2021

New variant may not have changed COVID-19 pandemic course in UK, says study

A new study examines the effect of the new "Kent variant" of SARS-CoV-2 on the epidemic course within the UK.

19 Mar 2021

Study examines efficacy of Pfizer-BioNTech mRNA COVID-19 vaccine across demographic groups

A new study examines data from Israel's vaccination campaign to assess the efficacy of the Pfizer-BioNTech mRNA vaccine across different demographics.

19 Mar 2021

New drug regimen is safe and effective in children with cystic fibrosis

An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children's Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least one copy of F508del mutation in the CFTR gene, which is estimated to represent almost 90 percent of the cystic fibrosis population in the United States.

19 Mar 2021

Chronic News and Research

Biological “feed-forward” loop contributes to progression of osteoarthritis

New review of post-acute COVID-19

New technique may result in earlier and easier identification of patients with Barrett's esophagus

Biological feed-forward loop drives cartilage cells in an arthritic joint to contribute to progression of the disease

Non-invasive scTS improves handgrip strength, motor control in people with complete tetraplegia

Study identifies metabolic processes associated with multiple, unrelated diseases

New method could drive down the production cost of antibodies

SARS-CoV-2 infection is circadian

Disease-driving B cells play a role in the development of NAFLD

Study: Early benefit assessment of new drugs within the framework of AM-NOG procedure

Stress-free life may lead to lower cognitive function

Clofazimine inhibits coronaviruses including SARS-CoV-2, study finds

Study maps structure and mechanism of a membrane enzyme that plays role in inflammation, cancer

$11 million COBRE funding will help create Center for Pre-Clinical Cancer Research at LSU SVM

VR offers hope to nerve injury patients experiencing chronic pain

Study reveals worsening health profiles in Gen X and Gen Y

Doctors found jet fuel in veteran’s lungs. He can’t get full benefits.

New variant may not have changed COVID-19 pandemic course in UK, says study

Study examines efficacy of Pfizer-BioNTech mRNA COVID-19 vaccine across demographic groups

New drug regimen is safe and effective in children with cystic fibrosis

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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