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CRISPRa method helps discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

3 Feb 2022

Innate and adaptive immune responses to SARS-CoV-2 in convalescent children and adults

In a new study, researchers explored the systemic immune responses during the acute and convalescent phases of SARS-CoV-2 in children and adults with the same disease severity.

3 Feb 2022

Study reveals peripheral blood biomarkers able to predict COVID-19 clinical outcomes in ICU admission

A new study involved the development of an immunological biomarker screen that upon ICU admission can predict the length of ICU stay or death.

3 Feb 2022

The ability of individuals to cross-recognize the Omicron spike protein following vaccination or prior infection

Scientists studied the ability of T cells to react with the Omicron spike.

2 Feb 2022

Quantitative framework to investigate the dynamic mechanism of host immune response confronting SARS-CoV-2 infection

The authors highlight that they have created a quantitative framework that allows the dynamic mechanism of the immune response to SARS-CoV-2 to be properly investigated.

2 Feb 2022

Study finds limited evidence for IL-1 blockers in treating COVID-19

Researchers assess the effectiveness and safety outcomes of interleukin-1 blocking agents in the treatment of COVID-19.

31 Jan 2022

Study identifies drugs that could help combat mortality in patients with COVID-19

Inflammation is a defense mechanism of the body to fight pathogens. However, when it is widespread and excessive, it can aggravate the pathology and even cause death.

31 Jan 2022

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Researchers demonstrate how cytotoxic T-lymphocytes (CTLs) with specificity for SARS-CoV-2 eliminate multiple infected targets.

30 Jan 2022

A synthesis of evidence sheds light on major immune components and mechanisms involved in COVID-19

New research highlights principal host factors that may explain the immune responses to SARS-CoV-2 and its variants in the context of infection susceptibility, disease severity, and previous immunity.

28 Jan 2022

γ’ fibrinogen as a disease progression marker for COVID-19

Levels of the inflammatory biomarker gamma prime fibrinogen (γ' Fbg) varies according to severity in COVID-19 patients.

28 Jan 2022

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.

27 Jan 2022

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Researchers assess the probability of T-cell apoptosis in patients with severe COVID-19 who were admitted to the hospital.

26 Jan 2022

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

A new study assesses SARS-CoV-2 antigen-specific cytokine responses in a cohort of SARS-CoV-2 infected individuals with varying levels of disease.

26 Jan 2022

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

In a new study, researchers evaluated SARS-CoV-2 vaccination-induced T cell responses cross-recognition among the early and novel SARS-CoV-2 variants.

26 Jan 2022

Exploring hematological alterations in COVID-19 patients

New study findings indicated that some hematological alterations that occur during COVID-19-related hospital admission were associated with an increase in the risk of COVID-19-associated ICU admission and mortality.

26 Jan 2022

Cannabidiol inhibits SARS-CoV-2 replication in human cells and mice

In research recently published in the journal of Science Advances, an interdisciplinary team of researchers from the University of Chicago assessed the potential role of cannabidiol (CBD), a natural product extracted from the cannabis plant, to prevent and inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in human cells and mice.

26 Jan 2022

SARS-CoV-2 infection and vaccination-induced T cells cross-recognize Omicron

In a recent study posted to the Nature In Review* preprint server, researchers performed a comprehensive, in-depth comparison of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell epitope repertoire following natural infection of coronavirus disease 2019 (COVID-19) compared to messenger ribonucleic acid (mRNA) vaccinations.

25 Jan 2022

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

In a recent study posted to the bioRxiv* preprint server, researchers evaluated the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated inflammatory marker interferon (IFN) repression in hosts.

25 Jan 2022

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

A new study investigated SARS-CoV-2 spike protein responses targeted by cross-reactive T cells that were isolated from convalescent COVID-19 individuals along with previously uninfected donors.

25 Jan 2022

Neurological complications of the SARS-CoV-2 vaccine

In a study published in the latest issue of the journal Neurological Sciences, a team of researchers described a three-patient case series presenting with neurological manifestations after the coronavirus disease 2019 (COVID-19) vaccination, followed by a literature review, to propose hypotheses on how neurological symptoms might develop after vaccination.

24 Jan 2022

Cytokine News and Research

CRISPRa method helps discover genes that play a role in immune cell biology

Innate and adaptive immune responses to SARS-CoV-2 in convalescent children and adults

Study reveals peripheral blood biomarkers able to predict COVID-19 clinical outcomes in ICU admission

The ability of individuals to cross-recognize the Omicron spike protein following vaccination or prior infection

Quantitative framework to investigate the dynamic mechanism of host immune response confronting SARS-CoV-2 infection

Study finds limited evidence for IL-1 blockers in treating COVID-19

Study identifies drugs that could help combat mortality in patients with COVID-19

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

A synthesis of evidence sheds light on major immune components and mechanisms involved in COVID-19

γ’ fibrinogen as a disease progression marker for COVID-19

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

Exploring hematological alterations in COVID-19 patients

Cannabidiol inhibits SARS-CoV-2 replication in human cells and mice

SARS-CoV-2 infection and vaccination-induced T cells cross-recognize Omicron

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

Neurological complications of the SARS-CoV-2 vaccine

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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