Transcription News and Research

RSS

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

9 Feb 2023

Detection of wild poliovirus type 3 in the Netherlands

Researchers detect wild poliovirus type 3 during the environmental surveillance of poliovirus essential facilities in the Netherlands.

8 Feb 2023

Macrophages suppress Escherichia coli LF82 Gally prophage lytic cycle

Researchers analyze prophages of the LF82 strain of adherent-invasive Escherichia coli to better understand their behavior in vitro and within macrophages.

8 Feb 2023

COVID-19 vaccination increases saliva antibody levels after asymptomatic infection

Researchers correlate SARS-CoV-2 load and neutralizing capacity of all saliva immunoglobulins isotypes in asymptomatic individuals.

8 Feb 2023

Study shows activation of pulmonary macrophages by SARS-CoV-2 spike glycoprotein

In a recent study published in the International Journal of Molecular Sciences, researchers investigated the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein on human lung macrophage (HLM) activation and angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) expression in human lung macrophages.

7 Feb 2023

Bivalent boosters provide additional protection from BA.5, XBB, and XBB.1.5

In a recent Morbidity and Mortality Weekly Report (MMWR) published on the United States Center for Disease Control and Prevention (US-CDC) website, researchers analyzed data from the Increasing Community Access to Testing (ICATT), a nationwide pharmacy program run in the US for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing.

7 Feb 2023

Mucoactive drugs block SARS-CoV-2 infection

Researchers evaluate the effects of mucociliary active molecules on SARS-CoV-2 infection in vitro.

7 Feb 2023

Study characterizes mutations in neuraminidase of human-like H5N1 influenza viruses

A study published in PLOS PATHOGENS describes the prevalence and functions of mutations in neuraminidase enzyme of avian H5N1 influenza viruses that are preferentially selected in human H5N1 influenza viruses.

7 Feb 2023

New research may explain why some patients suffer from long-COVID

A review article published in The Journal of Clinical Investigation deciphers the relationship between rare inborn errors of type I interferon immunity and the development of severe coronavirus disease 2019 (COVID-19) pneumonia.

6 Feb 2023

UT Southwestern research could lead to new ways of controlling gene regulation

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery.

3 Feb 2023

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

An unexpected discovery made by experts at the Brain Tumor Center at Cincinnati Children's while studying a rare-but-deadly type of brain tumor may also lead to improved treatments for several other forms of cancer that share a common influencing factor called a YAP fusion protein.

2 Feb 2023

Researchers report a heterologous vaccination strategy against IBV in Chickens

Researchers reported on the immunogenicity of a heterologous vaccine regimen against IBV, comprising prime doses of QAC-encapsulated plasmid and a booster dose of MVA.

2 Feb 2023

The trajectory of long-COVID in the general population of Scotland

Researchers presented the findings of the Long-COVID in Scotland Study (Long-CISS) conducted nationwide among the general population of Scotland.

2 Feb 2023

Risk factors for Omicron reinfections among previously infected frontline workers in the United States

Researchers examined a prospective cohort of frontline workers in the United States (US) previously infected with SARS-CoV-2. They attempted to identify risk factors that made this highly vulnerable population prone to reinfection by SARS-CoV-2 new variant of concern (VOC), Omicron, known for its high immune evading potential.

1 Feb 2023

Transcriptomics analysis identifies thousands of viroid-like circular RNA molecules

Metatranscriptomics analysis reveals the existence of over ten thousand viroids and viroid-like RNAs.

1 Feb 2023

Acute tubulointerstitial nephritis and uveitis in children post-COVID-19

A new study reported a novel form of post-acute coronavirus disease 2019 (COVID-19) syndrome in children.

31 Jan 2023

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore, led by Associate Professor Takaomi Sanda and Dr Lim Fang Qi, has breathed new life into an existing drug—combatting a type of blood cancer called T-cell acute lymphoblastic leukemia, or T-ALL.

30 Jan 2023

Study shows COVID-19 induces body fat and other metabolic changes

In a recent study published in the journal Cureus, researchers explored the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and levels of serum insulin, body fat distribution, and insulin resistance (IR) estimated by homeostasis model assessment (HOMA).

29 Jan 2023

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

A recent study evaluates the presence of SARS-CoV-2 in children’s tonsils during the COVID-19 pandemic.

29 Jan 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

Transcription News and Research

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Detection of wild poliovirus type 3 in the Netherlands

Macrophages suppress Escherichia coli LF82 Gally prophage lytic cycle

COVID-19 vaccination increases saliva antibody levels after asymptomatic infection

Study shows activation of pulmonary macrophages by SARS-CoV-2 spike glycoprotein

Bivalent boosters provide additional protection from BA.5, XBB, and XBB.1.5

Mucoactive drugs block SARS-CoV-2 infection

Study characterizes mutations in neuraminidase of human-like H5N1 influenza viruses

New research may explain why some patients suffer from long-COVID

UT Southwestern research could lead to new ways of controlling gene regulation

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

Researchers report a heterologous vaccination strategy against IBV in Chickens

The trajectory of long-COVID in the general population of Scotland

Risk factors for Omicron reinfections among previously infected frontline workers in the United States

Transcriptomics analysis identifies thousands of viroid-like circular RNA molecules

Acute tubulointerstitial nephritis and uveitis in children post-COVID-19

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

Study shows COVID-19 induces body fat and other metabolic changes

Children's tonsils are major sites of prolonged SARS-CoV-2 infection

Protein adduction and p53 tumor suppressor inhibition

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News