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Small peptide produced by gut bacteria identified as key factor in kidney fibrosis

A molecule made by bacteria in the gut can hitch a ride to the kidneys, where it sets off a chain reaction of inflammation, scarring and fibrosis - a serious complication of diabetes and a leading cause of kidney failure - according to a new study from researchers at the University of Illinois Urbana-Champaign and Mie University in Japan.

25 Aug 2025

Ciliary Hedgehog signaling controls the fate of fat precursor cells

Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue.

20 Aug 2025

OU researchers explore how cannabis use affects recovery after head and neck cancer surgery

University of Oklahoma researchers are conducting a first-of-its-kind study to determine whether cannabis use affects recovery from the wounds associated with head and neck cancer surgery. The outcomes may have implications for other types of surgery and conditions.

12 Aug 2025

New injectable skin graft mimics dermis and promotes healing

Researchers have created what could be called "skin in a syringe". The gel containing live cells can be 3D printed into a skin transplant, as shown in a study conducted on mice.

12 Aug 2025

The vicious circle of aging and metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: senescence of liver cells accelerates fat accumulation, inflammation and fibrosis, while chronic steatosis in turn hastens hepatic decline.

1 Aug 2025

Scarred liver tissue creates fertile ground for cancer development

Over 80% of hepatocellular carcinoma (HCC) – the third-leading cause of cancer deaths globally – emerges from advanced liver fibrosis or cirrhosis. A comprehensive review in Hepatology International synthesizes decades of research to reveal how scarred liver tissue becomes a breeding ground for cancer.

31 Jul 2025

Heavy drinking now poses greater liver disease risk than two decades ago

Americans who drink heavily are more than twice as likely to develop significant liver disease compared to 20 years ago, according to a new Keck Medicine of USC study published today in Clinical Gastroenterology and Hepatology.

23 Jul 2025

Heart scarring linked to abnormal rhythms in older male endurance athletes

Scar tissue in the heart was associated with abnormal heart rhythms among healthy, long-time male endurance athletes age 50 or older, potentially increasing their risk of sudden cardiac death, according to a small study published today in Circulation: Cardiovascular Imaging, an American Heart Association journal.

18 Jul 2025

MIT develops implantable device to automatically release emergency glucagon

For people with Type 1 diabetes, developing hypoglycemia, or low blood sugar, is an ever-present threat. When glucose levels become extremely low, it creates a life-threatening situation for which the standard treatment of care is injecting a hormone called glucagon.

9 Jul 2025

Novel method to improve the biocompatibility and chronic stability of neural electrode implants

An international research team, including scientists from the Institut de Neurociències at the Universitat Autònoma de Barcelona (UAB), has developed a new solution to reduce the immune response triggered by neural prosthetics used after limb amputations or severe nerve injuries.

30 Jun 2025

Endometriosis linked to higher odds of autoimmune conditions

New research links endometriosis to autoimmune diseases, revealing shared mechanisms that may lead to earlier diagnosis and targeted treatments for patients.

23 Jun 2025

Kupffer cell reprogramming in embryos explains metabolic disorders in offspring

Children born to obese mothers are at higher risk of developing metabolic disorders, even if they follow a healthy diet themselves.

18 Jun 2025

New switchable CAR-T therapy enters phase 1 trial for advanced breast cancer

The Calibr-Skaggs Institute for Innovative Medicines, the drug development division of Scripps Research, today announced a milestone in cancer treatment with the dosing of the first patient in a phase 1 trial (NCT06878248) evaluating CLBR001 + ABBV-461, a modular, switchable chimeric antigen receptor T cell (sCAR-T) therapy in patients with advanced or metastatic breast cancer who have no suitable treatment options.

18 Jun 2025