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'Cellular glue' opens the door to building tissues and organs

Researchers at UC San Francisco have engineered molecules that act like "cellular glue," allowing them to direct in precise fashion how cells bond with each other.

13 Dec 2022

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Researchers assessed the association of enhanced migratory or activated CD8+ T cell and reduced avidity reactive cellular response due to post-acute COVID-19 syndrome (PASC).

13 Dec 2022

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

Researchers from The University of Texas MD Anderson Cancer Center are presenting compelling findings from three clinical trials at the 2022 American Society of Hematology Annual Meeting.

13 Dec 2022

Study discovers link between a lesser-known hormone and lipid levels in midlife women

Step aside estrogen. Scientists at the University of Pittsburgh have discovered a predictor of blood lipid - or cholesterol - status for midlife women that may be key to understanding how hormone replacement therapy contributes to heart health.

12 Dec 2022

Individuals with depression less likely to adhere to medications following percutaneous coronary intervention

Patients diagnosed with depression were less likely to adhere to essential medical therapies following percutaneous coronary intervention (PCI) than those without depression, according to a new study published in JAMA Network Open by researchers at the University of Pittsburgh School of Medicine.

12 Dec 2022

Scientists use single-cell multi-omics data to map disease regulatory circuits

Researchers apply MAGICAL for the identification of modulated host response regulatory circuits in response to Staphylococcus aureus.

12 Dec 2022

How human cell atlases provide the missing links between genes, diseases and therapies

A Nature Medicine journal perspective article describes the potential of cell atlases in shaping the future of medicine. Providing the missing link between genes and diseases, single-cell atlases make it possible to develop more precise and specific diagnostic tools by understanding the mechanisms of complex diseases.

12 Dec 2022

Novel wearable device can monitor physiological parameters associated with heart failure in real-time

There are about 64 million cases of heart failure worldwide. According to the American Heart Association, 6.2 million adults in the United States have heart failure and that number is estimated to increase to 8 million by 2030.

12 Dec 2022

Novel drug shows early potential in combating multiple myeloma

A first-of-its-kind drug known as modakafusp alfa has shown early potential in combating multiple myeloma, a form of bone marrow cancer, in a study presented by researchers from the University of Pennsylvania's Abramson Cancer Center at the 2022 American Society of Hematology Annual Meeting (Abstract 565).

12 Dec 2022

Simplified treatment regimen results in dramatic decrease in early deaths from acute promyelocytic leukemia

The use of a simplified treatment regimen by oncologists, along with management recommendations and 24/7 support provided by a limited and dedicated group of academic disease experts, resulted in a dramatic decrease in early deaths from acute promyelocytic leukemia (APL).

12 Dec 2022

Many genetic disorders respond well to specialized gene therapy

When the normal DNA sequence in an individual changes or mutates it can cause disease. The mutation may involve multiple genes and may be caused by environmental factors, or there may be chromosomal defects that are harmful at birth, in infancy or environment at a later stage.

12 Dec 2022

Study provides new insights for the future development of oral insulin pill

WEHI researchers in Melbourne have answered a 100-year-old question in diabetes research: can a molecule different to insulin have the same effect? The findings provide important insights for the future development of an oral insulin pill.

12 Dec 2022

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

A patient with relapsed T cell leukemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

12 Dec 2022

Cambridge scientists develop a comprehensive tool for predicting individual's risk of prostate cancer

Cambridge scientists have created a comprehensive tool for predicting an individual's risk of developing prostate cancer, which they say could help ensure that those men at greatest risk will receive the appropriate testing while reducing unnecessary – and potentially invasive – testing for those at very low risk.

12 Dec 2022

Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia

A three-drug combination that sent chronic lymphocytic leukemia (CLL) into deep remissions in a broad group of patients in a clinical trial is highly effective in patients with high-risk forms of the disease, a new, phase 2 clinical trial led by Dana-Farber Cancer Institute investigators indicates.

12 Dec 2022

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Many children with ALL have a good outcome of their disease. After two years of chemotherapy treatment, nine out of ten children are cured. But some children have a more aggressive form of the disease.

12 Dec 2022

$Forxiga (dapagliflozin) approved in Great Britain for symptomatic chronic heat failure across the full spectrum of left ventricular ejection fraction$

Forxiga (dapagliflozin) approved in Great Britain for symptomatic chronic heat failure across the full spectrum of left ventricular ejection fraction

AstraZeneca today announced that the Medicines and Healthcare products Regulatory Agency (MHRA) has granted a licence extension for dapagliflozin in Great Britain for the treatment of symptomatic chronic heart failure (HF) in patients with HF and a left ventricular ejection fraction (LVEF) >40%, including HF with mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF).

From AstraZeneca 12 Dec 2022

Aging influences the diagnosis and treatment of heart attacks in patients over age 75

For people ages 75 and older, age-related changes in general health and in the heart and blood vessels require consideration and likely modifications in how heart attacks and heart disease are treated, according to a new American Heart Association scientific statement published today in the Association's flagship, peer-reviewed journal Circulation.

12 Dec 2022

Ongoing Phase I clinical trial demonstrates successful re-treatment with CAR T cell therapy

Researchers from the University of Pennsylvania's Abramson Cancer Center presented preliminary results of an ongoing Phase I clinical trial demonstrating successful re-treatment with CAR T cell therapy for patients whose cancers relapsed after previous CAR T therapy at the 2022 American Society of Hematology Annual Meeting.

12 Dec 2022

Off-the-shelf immunotherapy could offer new hope for patients with hard-to-treat multiple myeloma

A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials, according to researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.

12 Dec 2022

Blood News and Research

'Cellular glue' opens the door to building tissues and organs

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

Study discovers link between a lesser-known hormone and lipid levels in midlife women

Individuals with depression less likely to adhere to medications following percutaneous coronary intervention

Scientists use single-cell multi-omics data to map disease regulatory circuits

How human cell atlases provide the missing links between genes, diseases and therapies

Novel wearable device can monitor physiological parameters associated with heart failure in real-time

Novel drug shows early potential in combating multiple myeloma

Simplified treatment regimen results in dramatic decrease in early deaths from acute promyelocytic leukemia

Many genetic disorders respond well to specialized gene therapy

Study provides new insights for the future development of oral insulin pill

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

Cambridge scientists develop a comprehensive tool for predicting individual's risk of prostate cancer

Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Forxiga (dapagliflozin) approved in Great Britain for symptomatic chronic heat failure across the full spectrum of left ventricular ejection fraction

Aging influences the diagnosis and treatment of heart attacks in patients over age 75

Ongoing Phase I clinical trial demonstrates successful re-treatment with CAR T cell therapy

Off-the-shelf immunotherapy could offer new hope for patients with hard-to-treat multiple myeloma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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