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New research changes the paradigm of how people think about graft-versus-host disease

New research challenges the prevailing hypothesis for how donor stem cell grafts cause graft-versus-host disease, or GVHD, and offers an alternative model that could guide development of novel therapies.

30 Jan 2023

Novel class of sulfonamides to block malaria transmission

Malaria is a devastating disease, with 247 million cases and 619,000 deaths reported in 2021 alone. Malaria causes fever and a flu-like illness that occurs when people are infected with the parasite Plasmodium falciparum, which is spread by mosquitoes.

30 Jan 2023

Human immunodeficiency virus and hepatitis C virus detection using ribonucleic acid sequencing among smokers

Researchers identified serological Hepatitis C virus (HCV) signatures and human immunodeficiency virus (HIV) signatures through the secondary utilization of ribonucleic acid sequencing (RNA-seq) analysis data among previous and existing smokers with or without COPD (chronic obstructive pulmonary disease).

30 Jan 2023

Direct stochastic optical reconstruction microscopy combined with different labeling approaches for the visualization and quantification of ACE2 on different cells

Researchers performed dSTORM (direct stochastic optical reconstruction microscopy) with several labeling techniques for visualizing and quantifying ACE2 receptor expression on various cells.

30 Jan 2023

Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

Researchers investigated whether endothelial TLR3 insufficiency contributes to lung vascular remodeling induced by SARS-CoV-2.

30 Jan 2023

Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone

Researchers characterized immunological responses by pulmonary mucosal tissues post-COVID-19 vaccination and/or SARS-CoV-2 infection, to assess the impact of hybrid immune protection on the durability of mucosal immunological responses.

30 Jan 2023

Scientists Develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

Dual-action cell therapy engineered to eliminate established tumors and train the immune system to eradicate primary tumor and prevent cancer’s recurrence.

30 Jan 2023

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore, led by Associate Professor Takaomi Sanda and Dr Lim Fang Qi, has breathed new life into an existing drug—combatting a type of blood cancer called T-cell acute lymphoblastic leukemia, or T-ALL.

30 Jan 2023

Magnetic microrobot probe can quantify the stiffness and traction forces of cell colonies and embryos in vivo

In a recent study published in the journal Science Robotics, a team of researchers created a magnetic microrobot probe that can quantify the stiffness and traction force of tumor cell colonies and developing vertebrate embryos.

29 Jan 2023

Study shows COVID-19 induces body fat and other metabolic changes

In a recent study published in the journal Cureus, researchers explored the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and levels of serum insulin, body fat distribution, and insulin resistance (IR) estimated by homeostasis model assessment (HOMA).

29 Jan 2023

Using systems biology research to alter the properties of carcinogenic cells in the lungs

KAIST (President Kwang Hyung Lee) announced on January 30th that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering succeeded in using systems biology research to change the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.

29 Jan 2023

Serotonin can potentially accelerate degenerative mitral regurgitation, study says

Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University's Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children's Hospital of Philadelphia, the University of Pennsylvania, and the Valley Hospital Heart Institute.

29 Jan 2023

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

The vital role of oxytocin - the "love hormone" - for social attachments is being called into question. More than forty years of pharmacological and behavioral research has pointed to oxytocin receptor signaling as an essential pathway for the development of social behaviors in prairie voles, humans, and other species, but a genetic study publishing in the journal Neuron on January 27 shows that voles can form enduring attachments with mates and provide parental care without oxytocin receptor signaling.

29 Jan 2023

Biology underlying pair bonding and parenting may not be dictated by oxytocin receptors, study shows

Turning a decades-old dogma on its head, new research from scientists at UC San Francisco and Stanford Medicine shows that the receptor for oxytocin, a hormone considered essential to forming social bonds, may not play the critical role that scientists have assigned to it for the past 30 years.

27 Jan 2023

Researchers discover how measles virus can cause a rare but fatal neurological disorder

Researchers in Japan have uncovered the mechanism for how the measles virus can cause subacute sclerosing panencephalitis, or SSPE, a rare but fatal neurological disorder that can occur several years after a measles infection.

27 Jan 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

Activated neutrophils can become potent cancer fighters

Elevated levels of immune cells, called neutrophils, in tumors have been associated with poor outcomes in people with cancer.

27 Jan 2023

Treatment to boost white blood cells may benefit patients with glioblastoma

A new study led by Washington University School of Medicine in St. Louis reveals at least one cause of low white blood cell counts in patients treated for glioblastoma and demonstrates a potential treatment strategy that improves survival in mice.

27 Jan 2023

Top urologists share their insights and practical tips at "Urology on the Beach"

Desai Sethi Urology Institute brings renowned thought leaders to Miami Beach. From urologic cancers to female urology to male infertility to kidney stones and sexual health, top urologists from throughout the nation shared their insights and practical tips at "Urology on the Beach," a conference hosted January 13-15 by the Desai Sethi Urology Institute at the University of Miami Miller School of Medicine.

27 Jan 2023

Chemotherapy in the afternoon proved to be effective for female lymphoma patients

Chemotherapy is a commonly used regimen for cancer treatment, but it is also a double-edged sword. While the drugs are highly effective at killing cancer cells, they are also notorious for killing healthy cells in the body.

27 Jan 2023

Cell News and Research

New research changes the paradigm of how people think about graft-versus-host disease

Novel class of sulfonamides to block malaria transmission

Human immunodeficiency virus and hepatitis C virus detection using ribonucleic acid sequencing among smokers

Direct stochastic optical reconstruction microscopy combined with different labeling approaches for the visualization and quantification of ACE2 on different cells

Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone

Scientists Develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

Magnetic microrobot probe can quantify the stiffness and traction forces of cell colonies and embryos in vivo

Study shows COVID-19 induces body fat and other metabolic changes

Using systems biology research to alter the properties of carcinogenic cells in the lungs

Serotonin can potentially accelerate degenerative mitral regurgitation, study says

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

Biology underlying pair bonding and parenting may not be dictated by oxytocin receptors, study shows

Researchers discover how measles virus can cause a rare but fatal neurological disorder

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

Activated neutrophils can become potent cancer fighters

Treatment to boost white blood cells may benefit patients with glioblastoma

Top urologists share their insights and practical tips at "Urology on the Beach"

Chemotherapy in the afternoon proved to be effective for female lymphoma patients

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