Cytokine News and Research

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UC-MSC infusions reduce risk of death, quicken recovery time in severe COVID-19 cases

Dr. Camilo Ricordi, director of the Diabetes Research Institute and Cell Transplant Center at the University of Miami Miller School of Medicine, and his team of international collaborators are reporting the results of a groundbreaking randomized controlled trial showing umbilical cord-derived mesenchymal stem cell (UC-MSC) infusions safely reduce risk of death and quicken time to recovery for the most severe COVID-19 patients.

5 Jan 2021

SARS-CoV-2 infected alveolar type-II lung cells show senescence

Using monoclonal antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and senescent markers, researchers provide evidence that virus-infected lung cells acquire characteristics of cellular senescence, which also leads to expression of proinflammatory cytokines.

5 Jan 2021

Sugar-binding protein could promote inflammation and worsen sepsis

A sugar-binding protein could fuel terrible inflammation and worsen sepsis, a disease that kills more than 270,000 people every year in the US alone, reports a team of researchers led by UConn Health in the 4 January issue of Nature Immunology.

4 Jan 2021

Inflammation marker linked to increased fatigue in prostate cancer patients treated with ADT

Prostate cancer is one of the most common cancers among men in the U.S. For many patients, hormone therapy is a treatment option.

4 Jan 2021

Gut cells alert the body to danger during parasite invasion

To effectively combat an infection, the body first has to sense it's been invaded, then the affected tissue must send out signals to corral resources to fight the intruder.

28 Dec 2020

Immunologic modeling of COVID-19 severity and chronicity

In a new study by researchers at Universidad de Costa Rica and other institutions, a bioinformatics approach is used to determine whether Chronic COVID-19 (CC) might have a distinct immunologic signature compared to the mild to moderate (MM) or the severe/critical COVID-19.

24 Dec 2020

Kobe University and Sysmex conduct joint research on ELISPOT method for identifying COVID-19

Kobe University and Sysmex Corporation have been engaged in joint research on the ELISPOT method, a new blood test for identifying the novel coronavirus disease (COVID-19).

24 Dec 2020

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

A recent computational study from India implicated a dysregulated vitamin D pathway in the pathobiology of the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and opened the door for experimental validation of these observations.

23 Dec 2020

COVID-19 severity could be linked to genetic variance

A new study describes some potentially important genetic factors in the host that may shape the clinical symptoms and signs of the disease.

23 Dec 2020

CN Bio and University of Melbourne announce partnership focused on respiratory therapies for recovering COVID-19 patients

CN Bio, a leading cell culture company, that has developed single and multi-organ microphysiological systems (MPS) to improve the accuracy and efficiency of drug discovery, today announced a collaboration with the University of Melbourne, focused on respiratory therapies for recovering COVID-19 patients.

18 Dec 2020

Research examines processes of lung scarring and chronic rejection of organ after transplantation

Two new papers examine the processes of lung scarring and chronic rejection of the organ after transplantation, and potential therapies to stop the graft, or transplanted organ and its tissue, from failing.

17 Dec 2020

Research shows that people affected with COVID-19 suffer from cognitive effects

More and more evidence is coming out that people with COVID-19 are suffering from cognitive effects, such as brain fog and fatigue.

17 Dec 2020

WEHI researchers suggest potential new approach to treat stomach cancer

WEHI researchers have identified a key molecular regulator involved in the progression and spread of stomach cancer, suggesting a potential new approach to treat this devastating disease.

17 Dec 2020

SARS-CoV-2 surface proteins alter the expression of key chemokines and cytokines in cell lines

Researchers from the Washington University School of Medicine, United States of America, recently demonstrated that the SARS-CoV-2 surface proteins alone triggered innate cell activity and the interferon signaling pathway.

17 Dec 2020

SARS-CoV-2 RNA can be reverse-transcribed to be part of chimeric viral-human genome

A new study reveals that the genome of SARS-CoV-2 is inserted into the human genome, accounting for the detection of viral RNAs.

16 Dec 2020

CN Bio and the University of Melbourne collaborate to advance therapies for respiratory complications in recovered COVID-19 patients

From AXT Pty Ltd 16 Dec 2020

Recovered COVID-19 patients exhibit persistent cellular immunity

Researchers at The Rockefeller University in New York have conducted a study showing that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – triggers persistent T cell responses that last for at least six months.

14 Dec 2020

New analysis method could pave the way for important breakthroughs in immunotherapy

In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukemia. This has awakened hopes that this analysis method could pave the way for important breakthroughs in immunotherapy research and treatment.

11 Dec 2020

COVID-19 infection may also affect the central nervous system, cause neurological disorders

COVID-19 is known primarily as a respiratory disease, with symptoms that include cough, shortness of breath, and, in severe cases, acute respiratory distress syndrome and pneumonia

10 Dec 2020

Reverse phenotyping shows reactive T cell profiles in SARS-CoV-2 infection

A new study appearing as a preprint on the medRxiv* browser in December 2020 employs reverse phenotyping technology to explore T cell responses in COVID-19.

10 Dec 2020

Cytokine News and Research

UC-MSC infusions reduce risk of death, quicken recovery time in severe COVID-19 cases

SARS-CoV-2 infected alveolar type-II lung cells show senescence

Sugar-binding protein could promote inflammation and worsen sepsis

Inflammation marker linked to increased fatigue in prostate cancer patients treated with ADT

Gut cells alert the body to danger during parasite invasion

Immunologic modeling of COVID-19 severity and chronicity

Kobe University and Sysmex conduct joint research on ELISPOT method for identifying COVID-19

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

COVID-19 severity could be linked to genetic variance

CN Bio and University of Melbourne announce partnership focused on respiratory therapies for recovering COVID-19 patients

Research examines processes of lung scarring and chronic rejection of organ after transplantation

Research shows that people affected with COVID-19 suffer from cognitive effects

WEHI researchers suggest potential new approach to treat stomach cancer

SARS-CoV-2 surface proteins alter the expression of key chemokines and cytokines in cell lines

SARS-CoV-2 RNA can be reverse-transcribed to be part of chimeric viral-human genome

CN Bio and the University of Melbourne collaborate to advance therapies for respiratory complications in recovered COVID-19 patients

Recovered COVID-19 patients exhibit persistent cellular immunity

New analysis method could pave the way for important breakthroughs in immunotherapy

COVID-19 infection may also affect the central nervous system, cause neurological disorders

Reverse phenotyping shows reactive T cell profiles in SARS-CoV-2 infection

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