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Can preclinical COVID-19 models help unlock mystery of long-COVID?

In a recently published article in the journal PLOS PATHOGENS, scientists have summarized acute and prolonged clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The review also provides an overview of the potency and utility of preclinical animal models to understand the mechanistic details of acute and long coronavirus disease 2019 (COVID-19).

8 Sep 2022

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Researchers at the Johns Hopkins Kimmel Cancer Center, three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers.

8 Sep 2022

New gene therapy approach could help prevent blindness in children with Leber congenital amaurosis

Researchers from the National Eye Institute have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood.

8 Sep 2022

Clinical trial begins evaluating alternative strategies to administer the JYNNEOS monkeypox vaccine

A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun enrolling adult volunteers.

8 Sep 2022

SARS-CoV-2 infection leaves significant effects long after the patient is symptom-free

The immune cells of patients who received hospital care for COVID-19 early in the pandemic were still affected six months later.

8 Sep 2022

Annual flu shot may be linked with lower risk of stroke

Getting an annual flu shot may be associated with a lower risk of stroke, according to a study published in the September 7, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

8 Sep 2022

Triplet therapy slows progression of advanced kidney cancer

A targeted kinase inhibitor added to a two-drug immunotherapy combination slowed the progression of advanced kidney cancer in previously untreated patients, according to research led by an oncologist from Dana-Farber Cancer Institute.

8 Sep 2022

Donor iron deficiency produces no harmful effects on donated blood quality or donor wellbeing

Most of the U.S. blood supply comes from about 5 million altruistic volunteers who donate blood regularly. Frequent blood donation is known to result in iron deficiency in donors, which has led to concerns that the practice may not only diminish the quality of donated blood but also harm blood donors' health and quality of life.

8 Sep 2022

How does previous SARS-CoV-2 infection impact the B cell receptor repertoire in response to vaccination?

Researchers evaluated immune responses by B lymphocytes to Pfizer’s severe acute respiratory syndrome coronavirus 2 mRNA vaccine.

8 Sep 2022

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during neural development.

8 Sep 2022

Boosting vitamin D levels not associated with protection against respiratory tract infections or covid-19

Two large clinical trials published by The BMJ today show that boosting vitamin D levels in adults during the SARS-CoV-2 pandemic was not associated with protection against respiratory tract infections or covid-19.

8 Sep 2022

How does a walk in nature impact the brain?

A new study shows how exposure to nature through a one-hour walk in a natural setting can prevent mental strain and possibly reduce the incidence of mental ill-health.

8 Sep 2022

The effects of taurine supplementation on biomarkers of oxidative stress in women aged 55 to 70

Researchers investigated the effects of supplementing taurine on the biomarkers of oxidative stress in females.

8 Sep 2022

Researchers review the epidemiology, clinical character, treatment, and prevention of human monkeypox

Researchers reviewed the epidemiology, clinical character, treatment, and prevention of human monkeypox.

8 Sep 2022

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

A newly developed agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease, signaling its promise as a potential treatment for the disease, according to a team of researchers at UTHealth Houston.

8 Sep 2022

How does SARS-CoV-2 infection and vaccination impact human immune memory?

Researchers review current knowledge regarding the generation of immune memory responses and their durability post-infection and vaccination.

7 Sep 2022

Studies to explore whether achieving beneficial ketone levels can improve metabolic health of military service members

A series of upcoming studies will explore whether the grind of active-duty military life and veterans' disproportionately high incidence of chronic illness could be tamed by lifestyle interventions designed to achieve a metabolic state of nutritional ketosis.

7 Sep 2022

How does SARS-CoV-2 affect the male genitourinary system?

In a recent paper published in the American Journal of Clinical and Experimental Urology, researchers reviewed existing data on the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the male genitourinary (GU) tract.

7 Sep 2022

How does SARS-CoV-2 infection impact fertility in men?

In a recent review published in the journal Endocrines, researchers summarized existing literature findings on the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the male reproductive system and fertility.

7 Sep 2022

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

In a recent study posted to the bioRxiv* preprint server, researchers at the U.S National Institutes of Health demonstrated the efficacy of molnupiravir and nirmatrelvir, two oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals in the rhesus macaque model, the closest proxy to humans.

7 Sep 2022

Blood News and Research

Can preclinical COVID-19 models help unlock mystery of long-COVID?

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

New gene therapy approach could help prevent blindness in children with Leber congenital amaurosis

Clinical trial begins evaluating alternative strategies to administer the JYNNEOS monkeypox vaccine

SARS-CoV-2 infection leaves significant effects long after the patient is symptom-free

Annual flu shot may be linked with lower risk of stroke

Triplet therapy slows progression of advanced kidney cancer

Donor iron deficiency produces no harmful effects on donated blood quality or donor wellbeing

How does previous SARS-CoV-2 infection impact the B cell receptor repertoire in response to vaccination?

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

Boosting vitamin D levels not associated with protection against respiratory tract infections or covid-19

How does a walk in nature impact the brain?

The effects of taurine supplementation on biomarkers of oxidative stress in women aged 55 to 70

Researchers review the epidemiology, clinical character, treatment, and prevention of human monkeypox

New agonistic antibody reduced the amyloid pathology in mice with Alzheimer's disease

How does SARS-CoV-2 infection and vaccination impact human immune memory?

Studies to explore whether achieving beneficial ketone levels can improve metabolic health of military service members

How does SARS-CoV-2 affect the male genitourinary system?

How does SARS-CoV-2 infection impact fertility in men?

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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