Laboratory News and Research

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Novel preclinical model mimics persistent interneuron loss seen in preterm infants

Research-clinicians at Children's National Health System have created a novel preclinical model that mimics the persistent interneuron loss seen in preterm human infants, identifying interneuron subtypes that could become future therapeutic targets to prevent or lessen neurodevelopmental risks, the team reports Jan. 31, 2019, in eNeuro.

20 Feb 2019

Study may have important implications for refining parenting during child's adolescence

The field of adolescent psychology is increasingly focused on parents, with researchers asking how mothers and fathers control themselves (and their rising anger) in difficult interactions with their children.

20 Feb 2019

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system's ability to fight melanoma in mice.

20 Feb 2019

Newly developed gene therapy helps decelerate aging process

Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer's disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy to help decelerate the aging process.

20 Feb 2019

Cervical microbiome may influence HPV infection more than previously thought

Infections with a Human Papillomavirus cause 99 percent of cervical cancer cases, and the disease's first sign is often the appearance of precancerous lesions on a woman's cervix. But bacteria may play an important role, too.

19 Feb 2019

Once-a-day capsule offers new way to reduce symptoms of chronic breathlessness

More than 70,000 Australians who suffer from chronic breathlessness will now have access to life-changing medication to manage their symptoms.

19 Feb 2019

First molecular test predicts treatment response for kidney cancer

Immunotherapy drugs such as PD-L1 checkpoint inhibitors represent the front-line treatment for kidney cancer. But immunotherapy is expensive, benefits only a subset of patients and is futile in the majority of patients.

19 Feb 2019

Anti-cancer immunotherapy could be used to fight HIV

Researchers at the University of Montreal Hospital Research Centre have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy.

19 Feb 2019

Unique gene therapy approach paves new way to tackle rare, inherited diseases

Nonsense mutations are single-letter errors in the genetic code that prematurely halt the production of critical proteins. These unfinished proteins are unable to function normally, and nonsense mutations cause 10-15 percent of all inherited genetic diseases, including Duchenne muscular dystrophy, spinal muscular atrophy, cystic fibrosis and polycystic kidney disease.

19 Feb 2019

Researchers create new map of the brain's own immune system

A team of researchers under the direction of the Medical Center - University of Freiburg has created an entirely new map of the brain's own immune system in humans and mice.

19 Feb 2019

Study shows how 3D organization of genetic material helps perpetuate the species

From fathers to children, the delivery of hereditary information requires the careful packing of DNA in sperm. But just how nature packages this DNA to prepare offspring isn't clear.

19 Feb 2019

Harnessing the evolutionary games played by cancer cells to advance therapies

Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression.

19 Feb 2019

Researchers identify suicide toxin in the bacteria responsible for tuberculosis

The bacteria responsible for tuberculosis can be killed by a toxin they produce unless it is neutralized by an antidote protein. The European team of scientists behind this discovery is coordinated by researchers from the Institute of Pharmacology and Structural Biology and the European Molecular Biology Laboratory.

18 Feb 2019

New protocol can help identify febrile infants at low risk for serious bacterial infections

A national research team led by UC Davis Health clinicians and researchers from the University of Michigan, Nationwide Children's Hospital and Columbia University, has derived and validated a new protocol for emergency departments that can determine which infant patients with fevers, age 60 days or younger, are at low risk of significant bacterial infections.

18 Feb 2019

Using light-based method for production of pharmaceutical molecules

Photoelectrochemical cells are widely studied for the conversion of solar energy into chemical fuels. They use photocathodes and photoanodes to "split" water into hydrogen and oxygen respectively.

18 Feb 2019

CRISPR technology creates pluripotent stem cells that are 'invisible' to the immune system

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants.

18 Feb 2019

Customizing the Cellular Microenvironment to Improve Physiological Relevance

An interview with Marie-Charlotte Manus, discussing a new technology called PRIMO that improves the physiological relevance of cells in culture.

From Alveole 18 Feb 2019

Heavy smoking could lead to vision loss, study finds

Smoking more than 20 cigarettes a day can damage your vision, a study co-authored by a Rutgers researcher finds.

18 Feb 2019

Children from homes with flame-retardant sofa have high SVOC concentration in their blood

Children living in homes with all vinyl flooring or flame-retardant chemicals in the sofa have significantly higher concentrations of potentially harmful semi-volatile organic compounds in their blood or urine than children from homes where these materials are not present, according to a new Duke University-led study.

18 Feb 2019

New PET/CT tracer shows high detection rate for diagnosis of acute venous thromboembolism

A first-in-human study featured in the February issue of The Journal of Nuclear Medicine reports that the novel positron emission tomography/computed tomography tracer 18F-GP1 showed excellent image quality and a high detection rate for the diagnosis of acute venous thromboembolism.

18 Feb 2019

Laboratory News and Research

Novel preclinical model mimics persistent interneuron loss seen in preterm infants

Study may have important implications for refining parenting during child's adolescence

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Newly developed gene therapy helps decelerate aging process

Cervical microbiome may influence HPV infection more than previously thought

Once-a-day capsule offers new way to reduce symptoms of chronic breathlessness

First molecular test predicts treatment response for kidney cancer

Anti-cancer immunotherapy could be used to fight HIV

Unique gene therapy approach paves new way to tackle rare, inherited diseases

Researchers create new map of the brain's own immune system

Study shows how 3D organization of genetic material helps perpetuate the species

Harnessing the evolutionary games played by cancer cells to advance therapies

Researchers identify suicide toxin in the bacteria responsible for tuberculosis

New protocol can help identify febrile infants at low risk for serious bacterial infections

Using light-based method for production of pharmaceutical molecules

CRISPR technology creates pluripotent stem cells that are 'invisible' to the immune system

Customizing the Cellular Microenvironment to Improve Physiological Relevance

Heavy smoking could lead to vision loss, study finds

Children from homes with flame-retardant sofa have high SVOC concentration in their blood

New PET/CT tracer shows high detection rate for diagnosis of acute venous thromboembolism

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