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Study finds possible treatment strategy for Feingold syndrome type 1

A decrease in protein synthesis in cells of the developing gut contributes to a rare genetic disorder, and an inexpensive nutritional supplement may help reverse that decrease, according to a new study publishing November 1st in the open access journal PLOS Biology by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues. The finding is an advance in understanding the pathogenesis of the disease, and may lead to new treatments.

2 Nov 2022

New control system could be used to finely tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

1 Nov 2022

Extensive European study finds very high rates of long-COVID

In a recent study published by the European Center for Disease Prevention and Control, researchers assessed the prevalence of post-coronavirus disease 2019 (COVID-19) condition symptoms.

1 Nov 2022

Exploring viral loads of SARS-CoV-2 Omicron BA.5 and BA.2 sublineages

In a new study, researchers compared the viral loads of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.5 and BA.2 sublineages.

1 Nov 2022

Researchers fabricate cerebral cortical tissues in 3D and functionally integrate them into a brain lesion in mice

Researchers fabricated cerebral cortical tissues in 3D and functionally integrated them into a brain lesion in mice.

1 Nov 2022

The epigenetic alterations of monocytes in severe COVID-19

Researchers performed DNA methylation analysis on monocytes in the peripheral blood samples obtained from severe COVID-19 patients.

28 Oct 2022

Yeast reveals a key mechanism in how genes are controlled

Yeast, that simple organism essential to making beer and bread, has revealed for Cornell University researchers a key mechanism in how genes are controlled.

28 Oct 2022

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, an international team of researchers leveraged the human light chain apoferritin protomer-derived MULTI-specific, multi-Affinity antibody (Multabody, MB) platform for the generation of broad and potent SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)-neutralizing antibodies (Abs).

27 Oct 2022

Using stem cell cloning to identify the origin of lethal stomach and esophageal cancers

The University of Houston is leading a team of cancer researchers and experts in stem cell cloning to identify the origin of two very lethal cancers of the stomach and esophagus - esophageal adenocarcinoma (EAC) and intestinal gastric cancer (iGC).

27 Oct 2022

New discovery may change the textbook model of GPCR-mediated signaling

Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs.

27 Oct 2022

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

Researchers comparatively evaluated the neutralization antibody titers for SARS-CoV-2 Omicron VOC subvariants BA.1, BA.2, BA.4/5 among individuals with ancestral B.1 strain infections, vaccinated individuals, or with hybrid immunity from breakthrough infections and vaccinations with Delta or Gamma VOCs.

27 Oct 2022

What is the efficacy of RT-PCR assays for detection of SARS-CoV-2 in human semen?

A new study aimed to develop a standardized protocol for SARS-CoV-2 RNA detection in semen fractions used for assisted reproductive technology.

26 Oct 2022

DNA damage in older age increases expression of ACE2 and SARS-CoV-2 infection risk

Impaired DNA repair capacity among elderly increases expression of ACE2 receptor.

26 Oct 2022

Avian influenza virus introduced from Europe to North America through Iceland

A new study indicated that Iceland was the stepping stone for the translocation of the highly pathogenic avian influenza virus (HPAIV) between North America and Europe.

25 Oct 2022

Scientists use systems biology approach to identify molecular players in rheumatoid arthritis

Using a novel systems biology approach, scientists at University of California San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis (RA), a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.

24 Oct 2022

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Researchers performed a longitudinal cohort study to assess the levels of immunoglobulins M (IgM), G (IgG), and A (IgA) against the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

24 Oct 2022

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

Researchers investigated the efficacy of monovalent mRNA COVID-19 vaccines in immunocompromised adults during the Omicron dominance period starting December 2021.

24 Oct 2022

A novel approach for viral genomic surveillance

In a recent study posted to the bioRxiv* preprint server, researchers in the United States explored a novel technique to improve representation in viral genomic surveillance.

24 Oct 2022

Antibody-mediated protection against symptomatic COVID achieved at low serum neutralizing titers

In a recent study posted to the medRxiv* preprint server, researchers in the United States assessed the efficiency of protection mediated by antibodies against symptomatic coronavirus disease 2019 (COVID-19) at low serum-neutralizing titers.

24 Oct 2022

Research suggests that ORF6 is a major SARS-CoV-2 innate immune antagonist

In a recent study posted to the bioRxiv* server, researchers in the United States demonstrated how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 6 (ORF6) protein contributes to viral pathogenesis and modulates the host's immune responses.

23 Oct 2022

Transcription News and Research

Study finds possible treatment strategy for Feingold syndrome type 1

New control system could be used to finely tune the production of useful proteins

Extensive European study finds very high rates of long-COVID

Exploring viral loads of SARS-CoV-2 Omicron BA.5 and BA.2 sublineages

Researchers fabricate cerebral cortical tissues in 3D and functionally integrate them into a brain lesion in mice

The epigenetic alterations of monocytes in severe COVID-19

Yeast reveals a key mechanism in how genes are controlled

Combination of multi-specificity and antibody avidity enhances protection against SARS-CoV-2

Using stem cell cloning to identify the origin of lethal stomach and esophageal cancers

New discovery may change the textbook model of GPCR-mediated signaling

Vaccination- and/or natural infection-induced immune responses against SARS-CoV-2 Omicron subvariants

What is the efficacy of RT-PCR assays for detection of SARS-CoV-2 in human semen?

DNA damage in older age increases expression of ACE2 and SARS-CoV-2 infection risk

Avian influenza virus introduced from Europe to North America through Iceland

Scientists use systems biology approach to identify molecular players in rheumatoid arthritis

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

A novel approach for viral genomic surveillance

Antibody-mediated protection against symptomatic COVID achieved at low serum neutralizing titers

Research suggests that ORF6 is a major SARS-CoV-2 innate immune antagonist

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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