Cell News and Research

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Selectively targeting iGPX4 may be a promising therapeutic strategy for metabolic-associated fatty liver disease

This new article publication from Acta Pharmaceutica Sinica B, discusses targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease.

26 Sep 2022

Scientists identify immune targets for chemotherapy-resistant breast cancers

Scientists have identified immune cell types that could be targeted to develop specific immunotherapies in chemotherapy-resistant breast cancers.

26 Sep 2022

UTHSC professor receives $5 million to explore the gut as therapeutic target for treating disease

Radhakrishna Rao, PhD, vice-chair and professor in the Department of Physiology at the University of Tennessee Health Science Center (UTHSC), has received two large national awards totaling $5 million for separate studies involving the gut as a therapeutic target for treating disease.

26 Sep 2022

Research brings us closer to optimizing treatments for children with retinoblastoma

Retinoblastoma is a cancer of the eye that occurs in infants and toddlers and can lead to loss of vision, loss of one or both eyes, and even death.

26 Sep 2022

Study demonstrates how pan-sarbecovirus ORF7a protein plays a role in evading host immunity

In a new study, researchers demonstrated how sarbecovirus family down-regulates major histocompatibility complex-I (MHC-I) surface expression to evade cellular immunity.

26 Sep 2022

Systemic inflammation triggered by SARS-CoV-2 found to cause human testicular injury

In a new study, a team of researchers demonstrated that testicular injury in humans is not due to direct SARS-CoV-2 infection but more likely is an indirect effect of exposure to systemic inflammation or SARS-CoV-2 antigens.

26 Sep 2022

Omicron BA.1 breakthrough infection in vaccinated individuals recall memory B cells to confer immunity

In a new study, researchers followed up with individuals vaccinated with a COVID-19 vaccine based on the mRNA platform up to six months following Omicron BA.1 breakthrough infection to trace the evolution of their antibody immunity.

26 Sep 2022

Resistance of Russian Rhinolophus bats containing ACE2-dependent sarbecoviruses to COVID-19 vaccines

In a new study, researchers investigated the receptor tropism and serological cross-reactivity for spike (S) protein receptor-binding domains from two clade 3 sarbecoviruses found in Russian Rhinolophus (horseshoe) bats.

26 Sep 2022

What is the association between body fat and COVID-19?

Researchers recently assessed the association between adipose tissues and COVID-19 by evaluating autopsy cases and profiling adipose tissue responses to SARS-CoV-2 infections.

26 Sep 2022

Common germline variants of APOE contribute to differential COVID-19 outcomes

Researchers investigated the relationship between APOE4 genotype and COVID-19 outcomes using genetic models of mice.

26 Sep 2022

A fast and powerful method for the production of SARS-CoV-2 virus-like particles in insect cells

Researchers presented the direct plasmid transfection method for SARS-CoV-2 virus-like particle production in insect cells and applied the VLPs to evaluate the efficacy of monoclonal antibodies and vaccinated donor sera.

26 Sep 2022

The impact of sleep fragmentation on the clonal diversity of immune cells and the genetic aging of the hematopoietic system

A new study shows that sleep does much more, regulating the normal production of blood cells. This finding underlines how essential a healthy sleep routine is for a normal life.

26 Sep 2022

What are the effects of heavy metals on the risk of endometriosis in reproductive-age women?

The current study focuses on lead, arsenic, cadmium, and mercury, all of which have been linked to the disordered functioning of the human reproductive system.

26 Sep 2022

A good night's sleep promotes immunity

In a recent study published in the Journal of Experimental Medicine, researchers in the United States used mice models to understand how sleep fragmentation affects immunological responses and the epigenetic modifications of hematopoietic stem and progenitor cells (HSPCs). They also conducted a sleep restriction trial in humans to determine HPSC programming and hematopoiesis.

25 Sep 2022

Viruses exploit ability to sense the environment to maximize their infective yield

New UMBC-led research in Frontiers in Microbiology suggests that viruses are using information from their environment to "decide" when to sit tight inside their hosts and when to multiply and burst out, killing the host cell. The work has implications for antiviral drug development.

23 Sep 2022

Novel PTP1B inhibitor drug candidate can prevent lethal lung inflammation in mice

Neutrophils, the most abundant type of white blood cell, are the body's first line of defense against infection. Foreign pathogens can stress the body and activate neutrophils.

23 Sep 2022

DNA nets effectively target the spike protein and detect COVID-19 virus at very low levels

Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test – and also impeding the virus from infecting cells, opening a new possible route to antiviral treatment, according to a new study.

23 Sep 2022

Studies explore how differences in skin composition may lead to dermatological conditions

Why are certain body parts more prone to skin diseases than others? Two new UC Davis Health studies explored how differences in skin composition may lead to dermatological conditions, such as psoriasis and atopic dermatitis.

23 Sep 2022

Research reveals how carp virus uses a protein domain to inhibit host cell’s defense mechanisms

The team of Prof. Alain Vanderplasschen, virologist and immunologist at the University of Liège, has published an article in the journal Nucleic Acids Research, reporting ten years of research on how a carp virus has been using a protein domain called Zalpha (Zα) to inhibit the defense mechanisms of the host cell.

23 Sep 2022

Investigating a potential new treatment for glioblastomas

A research question posed in Pankaj Desai's lab has led to a decade of research, a clinical trial and major national funding to further investigate a potential new treatment for the most deadly form of brain tumors.

23 Sep 2022

Cell News and Research

Selectively targeting iGPX4 may be a promising therapeutic strategy for metabolic-associated fatty liver disease

Scientists identify immune targets for chemotherapy-resistant breast cancers

UTHSC professor receives $5 million to explore the gut as therapeutic target for treating disease

Research brings us closer to optimizing treatments for children with retinoblastoma

Study demonstrates how pan-sarbecovirus ORF7a protein plays a role in evading host immunity

Systemic inflammation triggered by SARS-CoV-2 found to cause human testicular injury

Omicron BA.1 breakthrough infection in vaccinated individuals recall memory B cells to confer immunity

Resistance of Russian Rhinolophus bats containing ACE2-dependent sarbecoviruses to COVID-19 vaccines

What is the association between body fat and COVID-19?

Common germline variants of APOE contribute to differential COVID-19 outcomes

A fast and powerful method for the production of SARS-CoV-2 virus-like particles in insect cells

The impact of sleep fragmentation on the clonal diversity of immune cells and the genetic aging of the hematopoietic system

What are the effects of heavy metals on the risk of endometriosis in reproductive-age women?

A good night's sleep promotes immunity

Viruses exploit ability to sense the environment to maximize their infective yield

Novel PTP1B inhibitor drug candidate can prevent lethal lung inflammation in mice

DNA nets effectively target the spike protein and detect COVID-19 virus at very low levels

Studies explore how differences in skin composition may lead to dermatological conditions

Research reveals how carp virus uses a protein domain to inhibit host cell’s defense mechanisms

Investigating a potential new treatment for glioblastomas

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