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Interactions between SIRT5 and SARS-CoV-2 Nsp14 protein

In a new study, researchers investigated the interactions between sirtuin 5 (SIRT5) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein (Nsp14) protein.

14 Sep 2022

Study highlights the efficacy of MVA-BN booster vaccination in inducing durable B cell memory responses against monkeypox

In a new study, researchers assessed the immunogenicity, safety, and booster-efficacy of the Modified Vaccinia virus Ankara-Bavarian Nordic (MVA-BN) vaccine currently being used for immunization against monkeypox.

14 Sep 2022

What is the impact of COVID-19 treatments targeting intracellular Neu1?

In a new study, researchers assessed the impact of targeting intracellular Neu1 on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

14 Sep 2022

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

A new study describes the changes in immune T cell profile over time following monkeypox infection.

14 Sep 2022

Study proposes a method for soothing and promoting sleep in crying infants

Most parents have experienced frustration when their infants cry excessively and refuse to sleep. Scientists have found that the best strategy to calm them down is by holding and walking with them for five minutes. This evidence-based soothing strategy is presented in a paper published September 13 in the journal Current Biology.

14 Sep 2022

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

In a recent study published in the journal eBioMedicine, researchers in Denmark and Sweden administered a cationic liposome-adjuvanted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine as a subcutaneous (s.c.) prime-intranasal (i.n.) boost strategy to elicit mucosal immune responses among SARS-CoV-2-infected Syrian hamsters.

14 Sep 2022

Manuka honey could cure serious lung infections caused by drug-resistant bacterium

In a recent study published in the journal Microbiology, researchers demonstrated that incorporating Manuka honey into nebulized antibiotic treatment could effectively combat respiratory infections due to Mycobacterium abscessusus, offering a novel new therapeutic strategy for M. abscessus management.

13 Sep 2022

MIT researchers use new technique to gather insight into repetitive protein sequences

About 70 percent of all human proteins include at least one sequence consisting of a single amino acid repeated many times, with a few other amino acids sprinkled in. These "low-complexity regions" are also found in most other organisms.

13 Sep 2022

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Through extensive single-cell analysis, researchers at The University of Texas MD Anderson Cancer Center have created a spatial map of tumor-infiltrating B cells and plasma cells in early-stage lung cancers, highlighting previously unappreciated roles these immune cells play in tumor development and treatment outcomes.

13 Sep 2022

Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

In an article published in the journal Expert Opinion on Drug Safety, scientists have described the safety and efficacy profiles of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies in pregnant women with coronavirus disease 2019 (COVID-19).

13 Sep 2022

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

Scientists define the immune responses against COVID-19 in HD patients who received three mRNA COVID-19 vaccine doses.

13 Sep 2022

New drug marks cancer cells for destruction by the immune system

Tumor cells are notoriously good at evading the human immune system; they put up physical walls, wear disguises and handcuff the immune system with molecular tricks.

13 Sep 2022

UC San Diego selected to lead components of the NIH Common Fund's Bridge2AI program

Researchers at University of California San Diego School of Medicine have been selected to lead components of the National Institutes of Health (NIH) Common Fund's Bridge to Artificial Intelligence (Bridge2AI) program.

13 Sep 2022

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain" - a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer.

13 Sep 2022

Gut commensal bacteria promote the development of virus-induced cancer by suppressing the immune system

Gut bacteria have a profound impact on health by aiding digestion, providing nutrients and metabolites, and working with the immune system to fend off pathogens.

13 Sep 2022

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

It is a known fact that consuming a large amount of alcohol, even for a few days, triggers fat accumulation in the liver and ultimately leads to alcohol-related liver diseases.

13 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

New drug induces similar effects as exercise to aid in the treatment of locomotor frailty

Maintaining a regular workout routine can help you look and feel great – but did you know that exercise also helps maintain your muscles and bones? People who are unable to engage in physical activity experience weakening of the muscles and bones, a condition known as locomotor frailty.

13 Sep 2022

NIH's Bridge2AI program aims to expand use of AI by biomedical and behavioral research communities

The National Institutes of Health will invest $130 million over four years, pending the availability of funds, to accelerate the widespread use of artificial intelligence (AI) by the biomedical and behavioral research communities.

13 Sep 2022

Cell News and Research

Interactions between SIRT5 and SARS-CoV-2 Nsp14 protein

Study highlights the efficacy of MVA-BN booster vaccination in inducing durable B cell memory responses against monkeypox

What is the impact of COVID-19 treatments targeting intracellular Neu1?

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

Study proposes a method for soothing and promoting sleep in crying infants

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

Manuka honey could cure serious lung infections caused by drug-resistant bacterium

MIT researchers use new technique to gather insight into repetitive protein sequences

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

New drug marks cancer cells for destruction by the immune system

UC San Diego selected to lead components of the NIH Common Fund's Bridge2AI program

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Gut commensal bacteria promote the development of virus-induced cancer by suppressing the immune system

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

New drug induces similar effects as exercise to aid in the treatment of locomotor frailty

NIH's Bridge2AI program aims to expand use of AI by biomedical and behavioral research communities

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