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Intestinal tissue-resident lymphocytes regulate their activity depending on glucose availability

A new study led by Marc Veldhoen, group leader at the Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) and Associate Professor at Faculdade de Medicina de Lisboa (FMUL) and published today in the scientific journal PNAS (Proceedings of the National Academy of Sciences of the United States of America) discovered that white blood cells that reside in the intestines, a specific group of immune cells called tissue-resident lymphocytes, use sugar as an energy source and have a faster metabolism than lymphocytes that circulate in the blood.

15 Aug 2022

Study paves new way to develop a predictive biomarker for TRAIL therapy

A cytokine named TRAIL binds to TRAIL receptors and kills cancer cells, but not normal cells. Therefore, various anticancer drugs targeting TRAIL receptors have been developed and gained great attention as a promising cancer therapeutics, but a certain population of cancer patients does not respond to the therapy.

15 Aug 2022

Researchers engineer artificial replicas of G protein-coupled receptors

How do signals from outside the cell cause a response inside it? Such outside signals could be hormones or neurotransmitters. To notice them, the cell's surface possesses receptors. One of the key classes of such receptors are so-called G protein-coupled receptors, or in short GPCRs.

15 Aug 2022

Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

In a new study, scientists identified an unmodified peptide addressing pre-hairpin spike (S) protein intermediate inhibiting SARS-CoV-2 infection.

15 Aug 2022

Single-dose therapeutic interfering particle lowers SARS-CoV-2 pathogenesis and shedding among hamsters

Researchers reported that a single-dose therapeutic interfering particle (TIP) lowers SARS-CoV-2 pathogenesis and shedding among hamsters.

15 Aug 2022

Study shows astrocytes as breeding grounds of SARS-CoV-2 during brain infection

Researchers evidenced the presence of SARS-CoV-2 in the human brain, infecting astrocytes and impairing neuronal function and viability.

15 Aug 2022

The impact of vaccination and prior infection on the infectiousness of individuals with SARS-CoV-2 Omicron infections in prison settings

Researchers evaluated the infectiousness of vaccine breakthrough infections and reinfections during the SARS-CoV-2 Omicron wave.

15 Aug 2022

Cell News and Research

Intestinal tissue-resident lymphocytes regulate their activity depending on glucose availability

Study paves new way to develop a predictive biomarker for TRAIL therapy

Researchers engineer artificial replicas of G protein-coupled receptors

Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

Single-dose therapeutic interfering particle lowers SARS-CoV-2 pathogenesis and shedding among hamsters

Study shows astrocytes as breeding grounds of SARS-CoV-2 during brain infection

The impact of vaccination and prior infection on the infectiousness of individuals with SARS-CoV-2 Omicron infections in prison settings

Do pre-existing antibodies alter the development of memory B cells in response to SARS-CoV-2 mRNA vaccination in humans?

Superior protection with 'mix-and-match' COVID-19 booster strategy

In monkeys, spike-based vaccines produce some immunity based on CD8 T-cells

How well does hybrid immunity protect against SARS-CoV-2 and its variants?

Why is COVID-19 more severe in people older than 50?

Men exposed to industrial air pollution exhibit sperm mitochondrial DNA deletions

How does birth weight affect long-term risk of mortality among men and women?

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

New method for 3D culture accurately quantifies how cancer cells generate forces to spread within tissue

What is the impact of heat treatment on monkeypox virus?

What are the unique traits of Long COVID?

What is the impact of COVID-19 on male reproductive health?

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

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