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NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

Natural killer (NK) cells derived from cord blood that were activated and complexed with a CD30/CD16A bispecific antibody elicited an 89 percent overall response rate in patients with relapsed or refractory CD30+ lymphoma, according to results from a phase I/II clinical trial presented at the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Patients with non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitor sotorasib (Lumakras) had a two-year overall survival rate of 32.5 percent, according to data from the CodeBreaK 100 clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

A new chimeric antigen receptor (CAR) T-cell product had an acceptable safety profile and showed early signs of efficacy as a monotherapy and in combination with an mRNA vaccine in patients with solid tumors, according to preliminary data from a phase I/II clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) finds that the consumption of healthy plant-based foods, including fruits, vegetables, nuts, coffee, and legumes, is associated with a lower risk of developing type 2 diabetes (T2D) in generally healthy people and support their role in diabetes prevention.

10 Apr 2022

Novel therapy advances to clinical trial for the treatment of glioblastoma

A novel therapy studied at the Medical College of Wisconsin (MCW) Cancer Center has led to a clinical trial for the treatment of glioblastoma, a rare and aggressive form of brain cancer, yet the most common primary brain tumor in adults.

10 Apr 2022

B-cells have significant differences in women with postpartum depression, finds study

A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it.

10 Apr 2022

Cancer risk and related mortality significantly higher among patients with kidney disease

Patients with kidney disease may have an increased risk of cancer and may be more likely to die from cancer.

8 Apr 2022

New delivery method enhances the "attack power" of CAR T cells against tumors

One cutting-edge cancer treatment exciting researchers today involves collecting and reprogramming a patient's T cells – a special set of immune cells – then putting them back into the body ready to detect and destroy cancerous cells.

8 Apr 2022

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

UNSW researchers have used CRISPR gene editing – a type of 'molecular scissors' – to understand how deletions in one area of the genome can affect the expression of nearby genes.

8 Apr 2022

Computational network science approach reveals new mechanisms for coronaviruses infections

A group of bat viruses related to SARS-CoV-2 can also infect human cells but uses a different and unknown entryway.

8 Apr 2022

City of Hope's late-breaking clinical trial data to be presented at AACR

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, will present late-breaking and clinical trial findings at this year's American Association for Cancer Research Annual Meeting, which begins today.

8 Apr 2022

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

On Thursday, April 7, the Centers for Medicare and Medicaid (CMS) formalized its plan to cover the anti-amyloid drug Aduhelm only for patients enrolled in clinical trials.

8 Apr 2022

New Alzheimer’s disease hypothesis could open up diagnosis or treatment possibilities

Alzheimer's Disease could be caused by damage to a protective barrier in the body that allows fatty substances to build up in the brain, newly published research argues.

8 Apr 2022

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

A new study demonstrated that vascular inflammation leads to heightened SARS-CoV-2 infection in perivascular cells.

8 Apr 2022

Depressive disorders are associated with general increase in the deformability of immune cells

A recent study by the TU Dresden and the University of Zurich in cooperation with the Max Planck Institute for the Science of Light establishes for the first time a link between depressive disorders and mechanical characteristics of all major blood cell types.

8 Apr 2022

Nanomedicine for treating life-threatening brain tumors

Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka) has announced that Dr. Sabina Quader et al. published a review article focusing on the recent nanomedicines for brain cancers on Advanced Drug Delivery Review in this March.

8 Apr 2022

Study finds higher risk of thrombotic events after SARS-CoV-2 infection

A study from Sweden published by The BMJ today finds an increased risk of deep vein thrombosis (a blood clot in the leg) up to three months after covid-19 infection, pulmonary embolism (a blood clot in the lung) up to six months, and a bleeding event up to two months.

8 Apr 2022

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

In a new study, researchers characterized over 100 SARS-CoV-2-specific CD4+ T-cell epitopes.

8 Apr 2022

Role of natural immunity to SARS-CoV-2 on post-vaccination antibody responses in staff and residents of long-term care facilities

A new study collected and analyzed sera from the staff at a local long-term care facility from August to December 2020, where an outbreak occurred in September 2020.

8 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

Blood News and Research

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

Novel therapy advances to clinical trial for the treatment of glioblastoma

B-cells have significant differences in women with postpartum depression, finds study

Cancer risk and related mortality significantly higher among patients with kidney disease

New delivery method enhances the "attack power" of CAR T cells against tumors

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

Computational network science approach reveals new mechanisms for coronaviruses infections

City of Hope's late-breaking clinical trial data to be presented at AACR

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

New Alzheimer’s disease hypothesis could open up diagnosis or treatment possibilities

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

Depressive disorders are associated with general increase in the deformability of immune cells

Nanomedicine for treating life-threatening brain tumors

Study finds higher risk of thrombotic events after SARS-CoV-2 infection

Study characterizes SARS-CoV-2 spike-specific cluster of differentiation 4+ T-cell response

Role of natural immunity to SARS-CoV-2 on post-vaccination antibody responses in staff and residents of long-term care facilities

Improved seroprevalence and antibody response after third COVID-19 vaccination

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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