CLARITY News and Research

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The lipid-exchanged, anatomically rigid, imaging/immunostaining compatible, tissue hydrogel (CLARITY) method was initially designed in 2013 by Chung and Deisseroth at the Stanford University School of Medicine. Using this process, post-mortem organs can be labeled for proteins and nucleic acids, enabling analysis of intact samples to create detailed 3D images.

Acucela, Otsuka Pharmaceutical granted FDA Fast Track designation for ACU-4429 in treatment of dry AMD

Acucela Inc., a clinical-stage biotechnology company focused on developing new treatments for blinding eye diseases, and Otsuka Pharmaceutical Co., Ltd., today announced that they have received Fast Track designation from the U.S. Food and Drug Administration (FDA) for ACU-4429, an investigational oral treatment for dry age-related macular degeneration (dry AMD).

17 Mar 2010

AstraZeneca Canada's IRESSA receives approval for treatment of NSCLC

AstraZeneca Canada announces the recently approved indication for IRESSA(R), a once-daily oral targeted therapy for the first-line treatment of patients with locally advanced (not amenable to curative therapy) or metastatic non-small cell lung cancer (NSCLC) who have activating mutations of the epidermal growth factor receptor-tyrosine kinase (EGFR-TK). In conjunction with this approval, AstraZeneca is also announcing the availability of a diagnostic test which can now determine a patient's EGFR mutation status, representing a new era in personalized lung cancer treatment in Canada.

17 Mar 2010

Toshiba displays new, advanced ultrasound systems at ACC annual meeting

Health care facilities use ultrasound as a first-line diagnostic exam to quickly and efficiently perform a range of patient exams, including cardiac imaging. Developed to meet these demanding clinical needs, Toshiba America Medical Systems, Inc. will showcase the advanced cardiac capabilities of its AplioTM MX and Aplio ArtidaTM ultrasound systems at this year’s American College of Cardiology (ACC) annual meeting in Atlanta, March 14-16, 2010 (Booth #1944). This is the first appearance of the Aplio MX at ACC.

16 Mar 2010

FDA provides guidance on Restanza clinical program in treatment of CABP

Advanced Life Sciences Holdings, Inc., a biopharmaceutical company engaged in the discovery, development and commercialization of novel drugs in the therapeutic areas of infection, oncology and respiratory diseases, announced today that the U.S. Food and Drug Administration has provided guidance on the clinical program required to assess the approvability of Restanza™ (cethromycin), a novel oral once-a-day antibiotic, in the treatment of outpatient community acquired bacterial pneumonia (CABP) as well as biodefense indications including anthrax, plague and tularemia.

11 Mar 2010

ADI’s 20-bit DAC enables superior image clarity, resolution, and contrast in medical imaging systems

MRI (magnetic resonance imaging) scans provide extraordinarily clear images of the human body and are commonly used to diagnose a wide range of illnesses and injuries, such as Alzheimer’s disease, cancerous tumors, and torn ligaments. Analog Devices, Inc., the leading provider of data conversion technology and longtime collaborator with the medical imaging industry, today introduced a breakthrough in data conversion that gives clinicians and radiologists the superior image clarity they need to see smaller anatomical structures and abnormalities, such as breast cancer cells, than ever before.

11 Mar 2010

Antibacterial activity of clay minerals raises hope for natural approaches to antibacterial cures

Alternative approaches to medicine are stock-in-trade in the ASU laboratory of microbiologist Shelley Haydel.

6 Mar 2010

CIGNA's Explanation of Benefits earns “Excellent” designation for Clarity, Content and Design

Health service company CIGNA has earned the top ranking among national health plans for the industry’s key customer communication, the Explanation of Benefits. CIGNA's Explanation of Benefits is one of only three to earn an “Excellent” designation for Clarity, Content and Design in an evaluation by DALBAR, Inc.

5 Mar 2010

P&R Dental Strategies develops and builds Rapid Review Imaging System for digitizing x-ray images

After nearly two decades building her company into the industry leader for third-party review of dental insurance claims, Dianne Rose, D.D.S., and principal of P&R Dental Strategies, Inc., was frustrated. In spite of many advances over the years in both dental x-ray technologies and the average quality of images supplied for review of dental claims, there was no consistency and, all-too-often, regardless of how up-to-date the x-ray equipment being used may have been, the images supplied were blurred and nearly useless for making accurate diagnostic determinations.

4 Mar 2010

FDA issues new draft guidance for Trius Therapeutics' proposed Phase 3 trial of torezolid phosphate

Trius Therapeutics, Inc. announced that on February 26th, 2010, the FDA issued new draft guidance on non-inferiority clinical trials that will apply to the design of the Company's proposed Phase 3 trials for its investigational antibacterial drug torezolid phosphate.

3 Mar 2010

Corneal transplant surgery: DSAEK leads to greater cell loss overall than PKP

One year post-surgery, patients who underwent Descemet's stripping automated endothelial keratoplasty (DSAEK) experienced greater cell loss overall compared to those who underwent penetrating keratoplasty (PKP), according to a new analysis of data collected from the Cornea Donor Study (CDS) Investigator Group's 2008 Specular Microscopy Ancillary Study (SMAS). However, the study, published in the March issue of Ophthalmology, showed that cell loss in DSAEK patients plateaued more quickly than in those who underwent PKP.

2 Mar 2010

AMA calls for fix to Medicare's doctor payments

With a sizable cut to Medicare physician payments taking effect in just one week, the American Medical Association is seeking clarity from Congress on its plan of action to stop the 21.2% reduction.

23 Feb 2010

Innovative 3-D interactive anatomy learning tools

Elsevier, the world's leading content provider of science and health information, today announced the availability of the InteractElsevier Series. Powered by CyberAnatomy, an Iowa-based company that creates interactive learning systems for students, the innovative 3-D interactive anatomy series applies advanced gaming technology to reviewing, learning and teaching anatomy. InteractElsevier has two levels of offerings - Web interactive (online) and virtual reality (stereoscopic).

23 Feb 2010

DSAEK cornea transplant offers potential long-term benefits

One year post-surgery, patients who underwent Descemet's stripping automated endothelial keratoplasty experienced greater cell loss overall compared to those who underwent penetrating keratoplasty, according to a new analysis of data collected from the Cornea Donor Study Investigator Group's 2008 Specular Microscopy Ancillary Study.

23 Feb 2010

Amerigroup's fourth-quarter revenues rise 18.5%

Amerigroup Corporation today announced that net income for the fourth quarter of 2009 was $40.2 million, or $0.79 per diluted share, versus $35.9 million, or $0.67 per diluted share, for the fourth quarter of 2008. For the year ended December 31, 2009, the Company's net income was $149.3 million, or $2.85 per diluted share.

19 Feb 2010

BPA has no effects on brain development: New study

This new study, which exposed pregnant rodents to a range of BPA dietary doses from low to high, concluded that BPA had no effects on brain development or behavior in their offspring that had been exposed to BPA in utero and throughout development. The robust study was conducted by highly qualified researchers at WIL Research Laboratories.

18 Feb 2010

Merck announces global sales of $27.4 billion for full-year 2009

Merck & Co., Inc. today announced financial results for the fourth quarter and the full year of 2009 which include the results of legacy Schering-Plough operations from the close of the merger on Nov. 3, 2009 through Dec. 31, 2009.

16 Feb 2010

Future studies may provide clarity on the best approach for pre-surgery beta blockers

In a commentary appearing in this week's Journal of the American Medical Association, heart specialists at the University of Michigan Health System make a plea for clarity on the best approach for prescribing beta blockers before surgery.

10 Feb 2010

First Edition: February 5, 2010

Today's headlines reflect Democrats' continuing efforts to regroup and advance a legislative strategy that includes health reforms.

5 Feb 2010

MISI opens new comprehensive spine care facility in Las Colinas

The Minimally Invasive Spine Institute, one of the most advanced diagnostic and treatment facilities for back and neck pain as well as spinal disorders in the United States, has opened a comprehensive spine care facility in Las Colinas to offer both holistic and traditional approaches to spine care, advancing physician practices by forever changing the patient experience.

2 Feb 2010

New testing method for early detection of cancer

A new testing method is being developed to detect cancer soon after the tumor has formed. It will identify characteristic substances in the blood which accompany a certain type of tumor. The first steps in the development have already been completed.

1 Feb 2010

CLARITY News and Research

Further Reading

Acucela, Otsuka Pharmaceutical granted FDA Fast Track designation for ACU-4429 in treatment of dry AMD

AstraZeneca Canada's IRESSA receives approval for treatment of NSCLC

Toshiba displays new, advanced ultrasound systems at ACC annual meeting

FDA provides guidance on Restanza clinical program in treatment of CABP

ADI’s 20-bit DAC enables superior image clarity, resolution, and contrast in medical imaging systems

Antibacterial activity of clay minerals raises hope for natural approaches to antibacterial cures

CIGNA's Explanation of Benefits earns “Excellent” designation for Clarity, Content and Design

P&R Dental Strategies develops and builds Rapid Review Imaging System for digitizing x-ray images

FDA issues new draft guidance for Trius Therapeutics' proposed Phase 3 trial of torezolid phosphate

Corneal transplant surgery: DSAEK leads to greater cell loss overall than PKP

AMA calls for fix to Medicare's doctor payments

Innovative 3-D interactive anatomy learning tools

DSAEK cornea transplant offers potential long-term benefits

Amerigroup's fourth-quarter revenues rise 18.5%

BPA has no effects on brain development: New study

Merck announces global sales of $27.4 billion for full-year 2009

Future studies may provide clarity on the best approach for pre-surgery beta blockers

First Edition: February 5, 2010

MISI opens new comprehensive spine care facility in Las Colinas

New testing method for early detection of cancer

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

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