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Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Novel approach pinpoints genetic variants involved in congenital heart disease

Nearly 1 percent of all children are born with congenital heart disease - a range of potentially life-threatening problems with the structure and function of their hearts. For most children, the precise causes of these frightening defects are unknown.

18 Feb 2022

New combination of antiviral drugs fails to improve outcomes in hospitalized patients with influenza

A new combination of antiviral drugs did not improve clinical outcomes in hospitalized patients with severe influenza, according results from a recent clinical trial published in The Lancet Infectious Diseases.

18 Feb 2022

Early antiretroviral therapy is crucial to fight against HIV and latent tuberculosis

Two weeks makes a big difference in treating the animal version of HIV and latent tuberculosis, researchers from Texas Biomedical Research Institute, Southwest National Primate Research Center and colleagues report this month in the Journal of Clinical Investigation.

18 Feb 2022

Research provides a stronger connection between autoantibody formation and clotting in COVID-19

Scientists have discovered that "rogue" antibodies found circulating in the blood of COVID-19 patients have the potential to cause cells to lose their resistance to clotting.

18 Feb 2022

Study reports a highly attenuated SARS-CoV-2 that could serve as a live-attenuated vaccine platform

The research showed a highly attenuated SARS-CoV-2 strain that might be used as a live-attenuated vaccine platform and a BSL-2 experimental system.

18 Feb 2022

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

Sickle cell anemia is an inherited blood disorder where red blood cells become sickle/crescent shaped. It causes frequent infections, swelling in the hands and legs, pain, severe tiredness and delayed growth or puberty.

18 Feb 2022

The ability of therapeutic monoclonal antibodies to neutralize SARS-CoV-2 Omicron BA.2 variant

Researchers evaluated the neutralizing capacity of the clinically approved mAbs against the SARS-CoV-2 Omicron BA.2 variant.

18 Feb 2022

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Researchers characterized the responses of the PBMCs at the individual cell and cell type levels against SARS-CoV-2 and SARS-CoV ex vivo.

18 Feb 2022

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Researchers investigated the connecting link between viral genetic variability and clinical heterogeneity of COVID-19 by analyzing the effect of several missense mutations on the ACE2 receptor coding sequence.

18 Feb 2022

Immunogenicity, efficacy, and safety of BNT162b2 or mRNA1273 fourth dose

A recent study explored the safety, immunogenicity, and VE of the SARS-CoV-2 mRNA BNT162b2 and mRNA1273 vaccines against its Omicron VOC in HCWs in Israel.

18 Feb 2022

Study shows mink can be infected by Omicron and efficiently transmit the virus to other mink

Researchers have been examining the pathology and spread of the Omicron variant in mink.

18 Feb 2022

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

A new study aimed to clarify whether extensive RBD mutations could affect the magnitude and immunodominance hierarchy of the host antibody response.

18 Feb 2022

Allegra V-15R benchtop centrifuge launched by Beckman Coulter Life Sciences during diamond year celebration

Celebrating a 75-year legacy in centrifugation, Beckman Coulter Life Sciences launches its most versatile 3-liter benchtop centrifuge yet – the Allegra V-15R refrigerated centrifuge.

From Beckman Coulter Life Sciences - Flow Cytometry 17 Feb 2022

Exposure to endocrine disrupting mixtures during pregnancy impacts children's brain development

By linking human population studies with experiments in cell and animal models, researchers have provided evidence that complex mixtures of endocrine disrupting chemicals impact children's brain development and language acquisition.

17 Feb 2022

New finding may aid in development of vaccines against future animal-to-human viral diseases

A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans - including SARS-CoV-2, the cause of COVID-19 - may be possible, say Johns Hopkins Medicine researchers, based on findings from their recent study.

17 Feb 2022

New mutation may define a high-risk subtype of pediatric acute myeloid leukemia

A new mutation was identified in 9 percent of relapsed cases of pediatric acute myeloid leukemia (AML) that may define a new subtype of the disease.

17 Feb 2022

Study reveals mechanisms associated with severe blood clotting in COVID-19 patients

After studying blood samples from 244 patients hospitalized for COVID-19, a group of researchers, including those who work at the National Institutes of Health, identified “rogue antibodies” that correlate with severe illness and may help explain mechanisms associated with severe blood clotting.

17 Feb 2022

Optical genome mapping holds potential to become an important component of leukemia diagnostics

Optical genome mapping involves the extraction of very long DNA molecules, for example routinely collected blood samples or bone marrow material from patients.

17 Feb 2022

Cell News and Research

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Novel approach pinpoints genetic variants involved in congenital heart disease

New combination of antiviral drugs fails to improve outcomes in hospitalized patients with influenza

Early antiretroviral therapy is crucial to fight against HIV and latent tuberculosis

Research provides a stronger connection between autoantibody formation and clotting in COVID-19

Study reports a highly attenuated SARS-CoV-2 that could serve as a live-attenuated vaccine platform

Drugs that increase fetal hemoglobin levels may help people with sickle cell disease

The ability of therapeutic monoclonal antibodies to neutralize SARS-CoV-2 Omicron BA.2 variant

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Immunogenicity, efficacy, and safety of BNT162b2 or mRNA1273 fourth dose

Study shows mink can be infected by Omicron and efficiently transmit the virus to other mink

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

Allegra V-15R benchtop centrifuge launched by Beckman Coulter Life Sciences during diamond year celebration

Exposure to endocrine disrupting mixtures during pregnancy impacts children's brain development

New finding may aid in development of vaccines against future animal-to-human viral diseases

New mutation may define a high-risk subtype of pediatric acute myeloid leukemia

Study reveals mechanisms associated with severe blood clotting in COVID-19 patients

Optical genome mapping holds potential to become an important component of leukemia diagnostics

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