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Set of genes appear to predict which tumors can evade detection by immune system

Johns Hopkins researchers say they have identified a set of genes that appear to predict which tumors can evade detection by the body's immune system, a step that may enable them to eventually target only the patients most likely to respond best to a new class of treatment.

5 Mar 2014

Plant pigment could prevent damage to nerves linked with childhood form of SMA

The research team have found that a plant pigment called quercetin - present in some fruits, vegetables, herbs and grains - could help to prevent damage to the nerves associated with the childhood form of motor neurone disease, spinal muscular atrophy (SMA).

5 Mar 2014

Researchers identify genes that appear to predict tumors that can evade detection by immune system

Johns Hopkins researchers say they have identified a set of genes that appear to predict which tumors can evade detection by the body’s immune system, a step that may enable them to eventually target only the patients most likely to respond best to a new class of treatment.

5 Mar 2014

Omeros submits investigational new drug to initiate OMS721 Phase 2 clinical program

Omeros Corporation today announced that it has submitted to the U.S. Food and Drug Administration (FDA) an investigational new drug (IND) application to initiate the Phase 2 clinical program for OMS721, the company's lead human monoclonal antibody targeting mannan-binding lectin‑associated serine protease-2 (MASP-2), the key regulator of the lectin pathway of the immune system.

4 Mar 2014

Research discovery advances efforts to replace damaged heart muscle

In a study that began in a pair of infant siblings with a rare heart defect, Johns Hopkins researchers say they have identified a key molecular switch that regulates heart cell division and normally turns the process off around the time of birth. Their research, they report, could advance efforts to turn the process back on and regenerate heart tissue damaged by heart attacks or disease.

4 Mar 2014

Outbursts of anger may trigger heart attacks and strokes, shows study

Outbursts of anger may trigger heart attacks, strokes and other cardiovascular problems in the two hours immediately afterwards, according to the first study to systematically evaluate previous research into the link between the extreme emotion and all cardiovascular outcomes.

4 Mar 2014

Angry outbursts increase heart attack risk

Call it what you will - getting red in the face, hot under the collar, losing your cool, blowing your top - we all experience anger. And while we know that anger is a normal, sometimes even beneficial emotion, we're also aware of the often harmful connection between anger and health. New research from Beth Israel Deaconess Medical shows an even more compelling reason to think about getting anger in check - a nearly fivefold increase in risk for heart attack in the two hours following outbursts of anger.

4 Mar 2014

3-D imaging of two different mouse models helps understand Apert Syndrome development

Three dimensional imaging of two different mouse models of Apert Syndrome shows that cranial deformation begins before birth and continues, worsening with time, according to a team of researchers who studied mice to better understand and treat the disorder in humans.

4 Mar 2014

OPKO Health consolidated revenues increase about 30% to $20.7 million in Q4 2013

OPKO Health, Inc., a multi-national biopharmaceutical and diagnostics company, today reported operating and financial results for its 2013 fourth quarter and full year ended December 31, 2013.

4 Mar 2014

Research roundup: Medicaid peer support; doctor Jokes; ACA's asset rules for coverage

Since 2009, the eight states (Alabama, Illinois, Louisiana, Massachusetts, New York, Utah, Virginia, and Wisconsin) participating in the Robert Wood Johnson Foundation's Maximizing Enrollment program have worked to streamline and simplify enrollment systems, policies, and processes for children and those eligible for coverage in 2014. ... States [focused] on five key areas: 1) applications, 2) eligibility determinations, 3) renewals and transfers, 4) notices, and 5) business processes.

3 Mar 2014

Scientists find certain species of nontuberculous mycobacteria in water that cause infection in humans

Brisbane's water supply has been found to contain disease carrying bugs which can be directly linked to infections in some patients, according to a new study by QUT.

3 Mar 2014

LMU researchers identify genetic mutations that result in overproduction of cortisol

An international team of researchers led by an endocrinologist at Ludwig-Maximilians-Universitaet (LMU) in Munich has identified genetic mutations that result in uncontrolled synthesis and secretion of the stress hormone cortisol.

28 Feb 2014

Auxilium Pharmaceuticals’ net revenues increase $125.9M to 56%

Auxilium Pharmaceuticals, Inc., a fully integrated specialty biopharmaceutical company, today announced financial results for the fourth quarter and full year ending December 31, 2013. The Company also highlighted select commercial, regulatory and clinical development progress and future goals and provided financial guidance for 2014.

28 Feb 2014

Obesity, contraceptives pills may increase risk of developing MS in later stages, says study

The role of the so-called "obesity hormone" leptin and hormones used for birth control in the development of multiple sclerosis (MS) is examined in two new studies released today that will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.

28 Feb 2014

Protein that controls Drosophila nervous system may play role in reversing brain injuries in human

A protein that controls the metamorphosis of the common fruit fly could someday play a role in reversing brain injuries, said Duke University researchers.

28 Feb 2014

Further support for hippocampal volume as psychosis biomarker

Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes provide further evidence that reduced hippocampal volume is a consistent feature of schizophrenia.

27 Feb 2014

Study: Direct camel-to-human transmission of MERS virus is possible in Saudi Arabia

An estimated three-quarters of camels recently surveyed in Saudi Arabia have evidence of infection with the Middle East Respiratory Syndrome coronavirus (MERS-CoV), the virus responsible for human cases of MERS.

27 Feb 2014

Patients with dental extractions before cardiac surgery still at risk for poor outcomes

To pull or not to pull? That is a common question when patients have the potentially dangerous combination of abscessed or infected teeth and the need for heart surgery.

27 Feb 2014

Study shows fructose consumption does not contribute to non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease is the most common chronic liver disease in developed countries, affecting up to 30 per cent of their populations.

27 Feb 2014

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

A study in this week's New England Journal of Medicine potentially has significant implications for prenatal testing for major fetal chromosome abnormalities. The study found that in a head-to-head comparison of noninvasive prenatal testing using cell free DNA (cfDNA) to standard screening methods, cfDNA testing (verifi- prenatal test, Illumina, Inc.) significantly reduced the rate of false positive results and had significantly higher positive predictive values for the detection of fetal trisomies 21 and 18.

From Illumina, Inc. 27 Feb 2014

Syndrome News and Research

Set of genes appear to predict which tumors can evade detection by immune system

Plant pigment could prevent damage to nerves linked with childhood form of SMA

Researchers identify genes that appear to predict tumors that can evade detection by immune system

Omeros submits investigational new drug to initiate OMS721 Phase 2 clinical program

Research discovery advances efforts to replace damaged heart muscle

Outbursts of anger may trigger heart attacks and strokes, shows study

Angry outbursts increase heart attack risk

3-D imaging of two different mouse models helps understand Apert Syndrome development

OPKO Health consolidated revenues increase about 30% to $20.7 million in Q4 2013

Research roundup: Medicaid peer support; doctor Jokes; ACA's asset rules for coverage

Scientists find certain species of nontuberculous mycobacteria in water that cause infection in humans

LMU researchers identify genetic mutations that result in overproduction of cortisol

Auxilium Pharmaceuticals’ net revenues increase $125.9M to 56%

Obesity, contraceptives pills may increase risk of developing MS in later stages, says study

Protein that controls Drosophila nervous system may play role in reversing brain injuries in human

Further support for hippocampal volume as psychosis biomarker

Study: Direct camel-to-human transmission of MERS virus is possible in Saudi Arabia

Patients with dental extractions before cardiac surgery still at risk for poor outcomes

Study shows fructose consumption does not contribute to non-alcoholic fatty liver disease

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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