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SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

In a recent study posted to the bioRxiv* preprint server, researchers evaluated the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated inflammatory marker interferon (IFN) repression in hosts.

25 Jan 2022

Nutritional components hold promise for improving the health and well-being of adults

Emerging research indicates that nutritional components that target specific mechanisms associated with age-associated cellular decline (AACD) hold promise for improving the health and well-being of adults.

25 Jan 2022

Beta-amyloid deposits found in young patients with COVID-19

A new study describes the finding that patients of COVID-19 exhibit large amounts of focal β-amyloid deposits in their neocortical tissues.

25 Jan 2022

Third dose of BNT162b2 vaccine protects against Omicron hospitalizations

A new study assesses the effectiveness of two and three doses of the BNT162b2 vaccine against Omicron-related hospitalizations.

25 Jan 2022

Spike-mediated CFTR inhibition accounts for airway inflammation in COVID-19

A new study looks at the molecular level inhibition of the protective CFTR gene by the SARS-CoV-2 spike protein.

25 Jan 2022

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Scientists have recently used synthetic biology to design primary human CD8 T cells to express Spike protein-specific chimeric antigen receptors (ACE2 CAR or anti-Spike CAR).

25 Jan 2022

Immunogenicity to BNT162b2 booster in adults who had previously received inactivated COVID-19 vaccination

A new preprint available on medRxiv* demonstrates the marked improvement in the immune response when the mRNA vaccine BNT162b2, from Pfizer/BioNTech, is used for the third dose after a primary two-dose series of an inactivated whole virus vaccine.

25 Jan 2022

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

A new study investigated SARS-CoV-2 spike protein responses targeted by cross-reactive T cells that were isolated from convalescent COVID-19 individuals along with previously uninfected donors.

25 Jan 2022

Research shows how a young healthy brain can successfully multitask while walking

New research turns the old idiom about not being able to walk and chew gum on its head. Scientists with the Del Monte Institute for Neuroscience at the University of Rochester have shown that the healthy brain is able to multitask while walking without sacrificing how either activity is accomplished.

25 Jan 2022

In Portugal risk of hospitalization from Omicron is 75% lower than Delta

Researchers from Portugal reported a 75% risk reduction in hospitalizations for individuals infected with Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to the Delta variant and a shorter length of stay and lower mortality if hospitalization does occur. Their paper is currently available on the medRxiv* preprint server while undergoing peer review.

24 Jan 2022

LA County study finds COVID-19 'herd immunity' unlikely

In a research letter published in the Journal of the American Medical Association (JAMA), researchers carried out a seroprevalence and vaccination coverage study in Los Angeles County (LAC).

24 Jan 2022

Common cystic fibrosis drugs work by directly aiding the protein folding process, study shows

Protein misfolding is a likely culprit in many degenerative disorders. Cystic fibrosis, for instance, is caused by mutations in the CFTR gene that prevent the eponymous protein from assuming its proper configuration.

24 Jan 2022

Current vaccines prompt the body to make effective, long-lasting T cells against SARS-CoV-2 variants

Scientists at La Jolla Institute for Immunology (LJI) have found that four COVID-19 vaccines (Pfizer-BioNTech, Moderna, J&J/Janssen, and Novavax) prompt the body to make effective, long-lasting T cells against SARS-CoV-2.

24 Jan 2022

The long-term neurologic consequences of COVID-19

A team of researchers recently provided insights into central nervous system consequences of the coronavirus disease 2019 (COVID-19) in a perspective paper published in the Science journal.

24 Jan 2022

Constructing SARS-CoV-2 virus-like particles in tobacco plants for vaccine development

In a study published in the latest issue of the Scientific Reports, a team of researchers constructed virus-like particles (VLPs) composed of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M), envelope (E), and nucleocapsid (N) proteins in tobacco plant using Agrobacterium-mediated delivery.

24 Jan 2022

Blood proteins could be potential targets for future drugs to slow aging process

Two blood proteins have been shown by scientists to influence how long and healthy a life we live, research suggests.

24 Jan 2022

Researchers develop a computational approach to identify genomic safe harbors for therapeutic genes

Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called "genomic safe harbors (GSHs)."

24 Jan 2022

Study explains why Omicron infections are less likely to cause severe disease

A new study by researchers from the University of Kent and the Goethe University Frankfurt shows that the SARS-CoV-2 Omicron variant is less effective than Delta at blocking a cellular defense mechanism against viruses, the so-called “interferon response”.

24 Jan 2022

Attenuated tissue immune responses against SARS-CoV-2 in obese and non-obese patients

In a new study, researchers evaluated the single-cell transcriptomes from bronchiolar lavage in three adult cohorts comprising of obese and non-obese SARS-CoV-2 patients.

24 Jan 2022

Novel gene therapy for diseased muscle fiber repair

In this interview, News-Medical speaks to Dr. Jyoti K. Jaiswal about his latest research into gene therapies for limb-girdle muscular dystrophy 2B.

24 Jan 2022

Cell News and Research

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

Nutritional components hold promise for improving the health and well-being of adults

Beta-amyloid deposits found in young patients with COVID-19

Third dose of BNT162b2 vaccine protects against Omicron hospitalizations

Spike-mediated CFTR inhibition accounts for airway inflammation in COVID-19

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Immunogenicity to BNT162b2 booster in adults who had previously received inactivated COVID-19 vaccination

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

Research shows how a young healthy brain can successfully multitask while walking

In Portugal risk of hospitalization from Omicron is 75% lower than Delta

LA County study finds COVID-19 'herd immunity' unlikely

Common cystic fibrosis drugs work by directly aiding the protein folding process, study shows

Current vaccines prompt the body to make effective, long-lasting T cells against SARS-CoV-2 variants

The long-term neurologic consequences of COVID-19

Constructing SARS-CoV-2 virus-like particles in tobacco plants for vaccine development

Blood proteins could be potential targets for future drugs to slow aging process

Researchers develop a computational approach to identify genomic safe harbors for therapeutic genes

Study explains why Omicron infections are less likely to cause severe disease

Attenuated tissue immune responses against SARS-CoV-2 in obese and non-obese patients

Novel gene therapy for diseased muscle fiber repair

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