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Nanotechnology platform can make solid tumor cells more receptive to immunotherapy

A team of researchers at The University of Texas MD Anderson Cancer Center has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy.

10 Nov 2022

Mosaic nanoparticles displaying spike protein trimers from different coronaviruses elicits cross-reactive protection

In a recent study under review at the Nature Portfolio journal and currently posted to Research Square* preprint server, researchers developed and assessed the immunogenicity of nanoparticles expressing spike trimers from coronaviruses (CoVs).

10 Nov 2022

Biodegradable transport nanoparticle can make anti-inflammatory drug more effective and less toxic

A team from UNIGE and LMU developed a transport nanoparticle to make an anti-inflammatory drug much more effective and less toxic.

9 Nov 2022

Empty lipid nanoparticles trigger maturation and activation of antigen-presenting cells

In a recent study posted to the Research Square* preprint server and under review at the Nature Portfolio journal, researchers reported activation and maturation of antigen-presenting cells (APCs) by lipid nanoparticles (LNPs).

9 Nov 2022

Does fenofibrate improve clinical outcomes in patients with COVID-19?

Researchers assessed the effect of fenofibrate on acute COVID-19.

9 Nov 2022

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

Cell growth and repair are stimulated by biomolecules known as cytokines and growth factors. Unfortunately, delivering adequate concentrations of these molecules to the brain for treating neurological conditions like Alzheimer's disease is challenging as they are either cleared out of the blood very quickly or do not penetrate neural tissue effectively.

8 Nov 2022

Researchers identify 55 broadly reactive monoclonal antibodies to betacoronaviruses

In a recent study published in the journal Cell Host & Microbe, researchers pursued novel approaches that could help find monoclonal antibodies (mAbs) broadly targeting coronaviruses (CoVs), especially genera beta CoVs.

8 Nov 2022

Study identifies novel inhibitors against SARS-CoV-2 main protease

In a recent study posted to the bioRxiv* server, researchers at the University of Arizona screened ~11 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro)-inhibiting small compounds in the ZINC15 database using a structure-based in-silico screening method.

8 Nov 2022

Scientists develop new electrochemical sensing platform to monitor vascularized tissue model

The costliness of drug development and the limitations of studying physiological processes in the lab are two separate scientific issues that may share the same solution.

8 Nov 2022

Study: Fenofibrate not a useful strategy for decreasing COVID-19 severity

After showing promise in early laboratory research, the cholesterol-lowering drug fenofibrate had no significant effect on COVID-19 outcomes in a multicenter international randomized clinical trial led by Penn Medicine scientists.

8 Nov 2022

COVID-19 amplifies damage to the central nervous system in Alzheimer's disease

In a recent study published in the journal Annals of Diagnostic Pathology, researchers in the United States evaluated the impact of coronavirus disease 2019 (COVID-19) on central nervous system (CNS) damage in Alzheimer's disease (AD).

7 Nov 2022

Study confirms the implication of Mib1 mutations in non-compaction cardiomyopathy

Non-compaction cardiomyopathy is a heart condition caused by defects that arise during fetal development and can have diverse health impacts in affected individuals, including sudden cardiac death.

7 Nov 2022

Beer hop compounds could serve as the basis for nutraceuticals to combat Alzheimer’s disease

Beer is one of the oldest and most popular beverages in the world, with some people loving and others hating the distinct, bitter taste of the hops used to flavor its many varieties.

7 Nov 2022

The Native Antigen Company expands its range of Omicron antigens to include BA.5 variant

The Native Antigen Company (part of LGC Clinical Diagnostics), one of the world’s leading suppliers of reagents that enables research into vaccines and diagnostics for emerging and endemic infectious diseases, today announced the commercial launch of its latest SARS-CoV-2 antigens for the newly designated Omicron BA.5 variant.

From The Native Antigen Company 7 Nov 2022

Beyond vaccines: emerging technologies capable of unlocking the promise of biologically targeted mRNA therapeutics

Researchers reviewed technology advancements that will unlock the promise of biologically targeted messenger ribonucleic acid (mRNA) therapeutics beyond vaccines.

7 Nov 2022

Study suggests anti-PF4 antibodies may play a role in the severe multiorgan disease manifestations of COVID-19

Researchers investigated the association between the increased levels of anti-platelet factor 4 antibodies and the clinical complications of COVID-19.

7 Nov 2022

Scientists map neural pathways that lead to vomiting after eating contaminated food

A new study describes a system by which gut-brain pathways coordinate with brain circuits to initiate nausea and vomiting.

6 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Novel platform allowing universal off-the-shelf T and NK cell access shows potential for immunotherapies

Recent advances in immunotherapy for cancer have stimulated a plethora of studies aimed at developing T cells (white blood cells) and Natural Killer (NK) cells (immune cells with enzymes that can kill tumor cells or cells infected with a virus) in-vitro from pluripotent stem cells - cells that are able to self-renew by dividing and developing into the three primary groups of cells that make up a human body.

3 Nov 2022

Vimentin is an important co-receptor for SARS-CoV-2 infection

Vimentin functions as a co-receptor for the entry of SARS-CoV-2 into host cells to facilitate infection.

2 Nov 2022

in vitro News and Research

Nanotechnology platform can make solid tumor cells more receptive to immunotherapy

Mosaic nanoparticles displaying spike protein trimers from different coronaviruses elicits cross-reactive protection

Biodegradable transport nanoparticle can make anti-inflammatory drug more effective and less toxic

Empty lipid nanoparticles trigger maturation and activation of antigen-presenting cells

Does fenofibrate improve clinical outcomes in patients with COVID-19?

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

Researchers identify 55 broadly reactive monoclonal antibodies to betacoronaviruses

Study identifies novel inhibitors against SARS-CoV-2 main protease

Scientists develop new electrochemical sensing platform to monitor vascularized tissue model

Study: Fenofibrate not a useful strategy for decreasing COVID-19 severity

COVID-19 amplifies damage to the central nervous system in Alzheimer's disease

Study confirms the implication of Mib1 mutations in non-compaction cardiomyopathy

Beer hop compounds could serve as the basis for nutraceuticals to combat Alzheimer’s disease

The Native Antigen Company expands its range of Omicron antigens to include BA.5 variant

Beyond vaccines: emerging technologies capable of unlocking the promise of biologically targeted mRNA therapeutics

Study suggests anti-PF4 antibodies may play a role in the severe multiorgan disease manifestations of COVID-19

Scientists map neural pathways that lead to vomiting after eating contaminated food

Fermented dairy products can improve gut mucosal immunity

Novel platform allowing universal off-the-shelf T and NK cell access shows potential for immunotherapies

Vimentin is an important co-receptor for SARS-CoV-2 infection

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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