Cell News and Research

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Statistical models predict outcomes for patients receiving non-intensive AML therapy

An international team has developed statistical models to predict the risk of early death in patients being treated with non-intensive therapies for acute myeloid leukemia (AML).

12 Dec 2021

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Mount Sinai physician-scientists have found that a novel therapy for the bone marrow cancer myelofibrosis is safe and well-tolerated and is associated with modest improvements in patients in a Phase 1b clinical trial.

12 Dec 2021

Clinical studies show enhanced responses for lymphoma patients treated with axi-cel CAR T cell therapy

Three clinical studies led by researchers at The University of Texas MD Anderson Cancer Center demonstrated enhanced responses for patients with high-risk lymphoma treated with axicabtagene ciloleucel (axi-cel) chimeric antigen receptor (CAR) T cell therapy.

12 Dec 2021

Researchers discover why people with asthma have lower brain tumor risk

There's not much good that can be said about asthma, a breathing disease in which the airways become narrowed and inflamed.

11 Dec 2021

TP53 mutations in men may predispose to aggressive prostate cancer

Men who have mutations in a gene called TP53 have a high risk of developing aggressive prostate cancer, a multicenter research team in the United States has found.

11 Dec 2021

Nasal vaccine provides broad-based protection against heterologous respiratory viruses in mice

The emergence of COVID-19 variants such as delta and omicron have sent scientists scrambling to determine whether existing vaccinations and boosters are still effective against new strains of SARS-Cov-2.

11 Dec 2021

UCLA research points the way towards a longer-lasting COVID vaccine

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified rare, naturally occurring T cells that are capable of targeting a protein found in SARS-CoV-2 and a range of other coronaviruses.

11 Dec 2021

Rare population of toxic senescent cells in the brain could be a target for Alzheimer's treatment

For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer's disease treatment.

11 Dec 2021

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma.

11 Dec 2021

Researchers discover new mechanism behind the formation of membrane vesicles

Canadian and American researchers have discovered a new mechanism by which membrane vesicles are made. These self-contained nanoparticles trap proteins, RNA and other molecules from inside or outside of living cells as nutrients or regulate the numbers of cell surface hormone receptors, such as those for insulin, to control the sensitivity of cells to hormones.

10 Dec 2021

Indication of minor added benefit of nivolumab for adjuvant treatment of esophageal cancer

In an early benefit assessment, the German Institute for Quality and Efficiency in Health Care investigated whether nivolumab has an added benefit over watchful waiting in the adjuvant treatment of adults with carcinoma of the esophagus or the gastroesophageal junction and pathological residual disease after prior neoadjuvant chemoradiotherapy (CRT).

10 Dec 2021

Screening FDA-approved compounds shown to possess antiviral or antimicrobial activity for SARS-CoV-2 inhibition

Researchers have screened several compounds that could show the ability to inhibit SARS-CoV-2.

10 Dec 2021

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Researchers discovered that the entry of coronaviruses is a Ca2+-dependent process and focused their studies on the SARS-1 FP-Ca2+ interaction and its effect on membranes using electron spin resonance (ESR).

10 Dec 2021

Study finds sarbecoviruses circulating in wildlife outside Asia can infect human cells

A recent study tested the RBD of 2 sarbecoviruses found in Russian horseshoe bats and other clades 3 viruses for their ability to invade the human cell.

10 Dec 2021

Insight into immune cell communication may pave the way for new cancer vaccines

In the past decade, immunotherapy has helped save the lives of many cancer patients, many with lung cancer, who might have otherwise faced almost certain death sentences.

9 Dec 2021

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

A University of Florida Health researcher has successfully analyzed the many mutations in the omicron variant of the SARS-CoV-2 virus, a crucial step in better understanding the variant's potential threat and ways to combat it.

9 Dec 2021

Researchers review transmission, origin, pathogenesis, animal model and diagnosis of Zika virus

Announcing a new article publication for Zoonoses journal. Dallas Vue and Qiyi Tang from Howard University College of Medicine, Washington, DC, USA review transmission, origin, pathogenesis, animal model and diagnosis of Zika Virus.

9 Dec 2021

Researchers recapitulate the human form of arrhythmogenic cardiomyopathy in zebrafish model

The research groups of Jeroen Bakkers (Hubrecht Institute/UMC Utrecht) and Toon van Veen (UMC Utrecht) bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM).

9 Dec 2021

Investigational mRNA-based HIV vaccine shows promise in mice and non-human primates

An experimental HIV vaccine based on mRNA—the same platform technology used in two highly effective COVID-19 vaccines—shows promise in mice and non-human primates, according to scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

9 Dec 2021

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Researchers from the Centro de Investigaciones Biológicas Margarita Salas have been investigating one of the mutations that typically appear in the Delta variant.

9 Dec 2021

Cell News and Research

Statistical models predict outcomes for patients receiving non-intensive AML therapy

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Clinical studies show enhanced responses for lymphoma patients treated with axi-cel CAR T cell therapy

Researchers discover why people with asthma have lower brain tumor risk

TP53 mutations in men may predispose to aggressive prostate cancer

Nasal vaccine provides broad-based protection against heterologous respiratory viruses in mice

UCLA research points the way towards a longer-lasting COVID vaccine

Rare population of toxic senescent cells in the brain could be a target for Alzheimer's treatment

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Researchers discover new mechanism behind the formation of membrane vesicles

Indication of minor added benefit of nivolumab for adjuvant treatment of esophageal cancer

Screening FDA-approved compounds shown to possess antiviral or antimicrobial activity for SARS-CoV-2 inhibition

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Study finds sarbecoviruses circulating in wildlife outside Asia can infect human cells

Insight into immune cell communication may pave the way for new cancer vaccines

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

Researchers review transmission, origin, pathogenesis, animal model and diagnosis of Zika virus

Researchers recapitulate the human form of arrhythmogenic cardiomyopathy in zebrafish model

Investigational mRNA-based HIV vaccine shows promise in mice and non-human primates

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

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