ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Study finds underutilization of aspirin to prevent colorectal cancer in high risk patients

Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor.

7 Feb 2019

Low-salt diet may be more beneficial for females than males

A low-salt diet may be more beneficial in lowering blood pressure in females than males, report scientists who found that while actual salt retention isn't higher in females, there is still an effect that drives pressure up.

11 Dec 2018

Drug therapy can improve outcomes for acutely ill heart patients

A drug therapy used for patients with chronic heart failure also improves markers of poor prognosis in individuals who are hospitalized with acute heart failure, new Yale-led research shows.

12 Nov 2018

UA professor wins NIH grant to advance research in preventing heart failure

A University of Arizona College of Medicine - Phoenix researcher has received a $393,493 grant from the National Institutes of Health to further her research in reducing the risk of heart failure in patients with high blood pressure.

1 Nov 2018

New statement provides detailed overview of how to diagnose, treat resistant hypertension

Resistant hypertension affects 12 percent to15 percent of patients treated for high blood pressure according to a new scientific statement from the American Heart Association.

14 Sep 2018

Hypertension drugs may be used to preserve memory of lupus patients

Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus.

5 Sep 2018

$Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction$

Entresto drug can be initiated early and safely in heart failure patients with reduced ejection fraction

Data from the TRANSITION study presented today at the European Society of Cardiology Congress in Munich, Germany has shown that Entresto® can be initiated early and safely in a wide range of heart failure patients with reduced ejection fraction who have been stabilized after hospitalization due to an acute heart failure episode.

25 Aug 2018

Drug in clinical trials for Parkinson's disease offers hope for treating heart failure

A drug currently in clinical trials for treating symptoms of Parkinson's disease may someday have value for treating heart failure, according to results of early animal studies by Johns Hopkins Medicine researchers.

20 Jul 2018

Study suggests proteinuria lowering as important target in managing pediatric CKD

In a study of children with chronic kidney disease, blood pressure medications reduced protein excretion in the urine, which was linked with a lower risk of disease progression.

22 Jun 2018

Prescription drugs that could raise risk of depression

Researchers are working towards understanding how use of certain regularly used prescription drugs could be raising the risk of getting depression. The study was published yesterday in the latest issue of the Journal of the American Medical Association.

13 Jun 2018

Patients taking aspirin before and after CABG surgery show reduced mortality risk

New research presented at this year's Euroanaesthesia congress in Copenhagen, Denmark shows that in patients undergoing a coronary artery bypass graft surgery, taking aspirin before and after surgery is associated with an 18% to 34% reduced mortality risk after 4 years.

4 Jun 2018

Fewer women meet eligibility criteria for clinical trial of heart failure drugs, study finds

Clinical trial enrolment favors men, according to a study presented today at Heart Failure 2018 and the World Congress on Acute Heart Failure, a European Society of Cardiology congress. The study found that fewer women meet eligibility criteria for trials of heart failure medication.

28 May 2018

Increasing physical activity over six years associated with decreased heart failure risk

By analyzing reported physical activity levels over time in more than 11,000 American adults, Johns Hopkins Medicine researchers conclude that increasing physical activity to recommended levels over as few as six years in middle age is associated with a significantly decreased risk of heart failure, a condition that affects an estimated 5 million to 6 million Americans.

15 May 2018

Controlling blood pressure can prevent dementia in older African-Americans with hypertension

Controlling blood pressure with any of the commonly prescribed antihypertensive medications can prevent dementia in older African-Americans with hypertension according to a new study from Regenstrief Institute researchers.

9 Apr 2018

Two types of blood pressure medications linked to increased variability, higher risk of death

Two types of blood pressure medications -; alpha blockers and alpha 2 agonist -; show increased variability in blood pressure measurements between doctor visits, which is associated with an increased risk of death, according to new research from the Intermountain Medical Center Heart Institute in Salt Lake City.

13 Mar 2018

Novel screening tool aids search for curative kidney treatment

Researchers have developed a screening tool for identifying compounds that restore functionality of the protein that is dysfunctional in Alport syndrome.

9 Mar 2018

Study finds Ramadan fasting to be safe for heart failure patients

Ramadan fasting can be safe for patients with heart failure, according to research presented today at the 29th Annual Conference of the Saudi Heart Association, held 1 to 3 March in Riyadh, Saudi Arabia.

1 Mar 2018

Discovery of molecular nets may lead to new treatment approach for heart failure

Local researchers have discovered that a group of molecules, called chondroitin sulfate, normally found only in connective tissues such as the cartilage, accumulates and causes inflammation in the hearts of patients with heart failure.

31 Jan 2018

Study: Traffic-related air pollutants appear to thwart benefits of walking among older adults

Even short-term (2 hour) exposure to tiny particles of soot or dust found in traffic fumes on busy roads appears to thwart the benefits of walking on the heart and lungs among older adults (aged 60 or over), according to a study comparing the health effects of walking along a traffic-polluted road versus walking through a park.

7 Dec 2017

Recommendations to prevent heart failure hospitalizations

Heart failure (HF) affects approximately 5.7 million adults in the United States according to the Centers for Disease Control and Prevention. If not properly managed, HF can lead to frequent hospitalizations.

10 Nov 2017