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Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

Researchers explored the molecular basis for increased immunity against heterologous SARS-CoV-2 strains after repeated antigen exposures.

1 Jul 2022

The antiviral effects of thiol drugs in COVID-19

A recent study investigated the effects of thiol drugs on SARS-CoV-2.

1 Jul 2022

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

A recent study posted to the bioRxiv* preprint server supports using mosaic sarbecovirus receptor-binding domain (RBD)-nanoparticles to discover therapeutic pan-variant and pan-sarbecovirus monoclonal antibodies (mAbs) and to induce mAbs by vaccination.

30 Jun 2022

Age-specific susceptibility during the Omicron driven, Delta driven, and pre-Delta waves in South Korea

Researchers assessed the relative age-varying susceptibility to SARS-CoV-2 Omicron strain infections compared to the SARS-CoV-2 Delta strain and pre-Delta strains in South Korea.

30 Jun 2022

The effects and mechanisms of SARS-CoV-2 on the nervous system

Researchers reviewed the neurologic manifestations associated with SARS-CoV-2.

30 Jun 2022

SARS-CoV-2 3CLpro also susceptible to mutations

Researchers assess the activity of all potential mutations in the SARS-CoV-2 3CLpro.

29 Jun 2022

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Researchers assessed the impact of SARS-CoV-2 envelope protein on the bromodomain and extraterminal domain (BET) proteins.

29 Jun 2022

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States described a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibody (mAb) SP1-77 that broadly neutralized its multiple variants of concern (VOCs).

28 Jun 2022

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

Scientists from China have recently deciphered the genetic network and biological mechanisms associated with COVID-19 myocarditis using bioinformatic methods.

28 Jun 2022

The potential of DNA-based SARS-CoV-2 vaccine candidates

Researchers evaluated the immunogenicity of DNA-based candidate vaccines against SARS-CoV-2 in mice.

28 Jun 2022

Cell-based assay highlights differences in antibody neutralizing capacity for SARS-CoV-2 variants

A recent study by scientists at Celentyx Ltd, the University of Birmingham, and the University of Warwick and posted to the bioRxiv* preprint server illustrated a cell-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein attachment assay.

28 Jun 2022

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatment

A recent study posted to the bioRxiv* preprint server assessed whether niclosamide could be employed in coronavirus disease 2019 (COVID-19) therapy.

28 Jun 2022

Omicron variant of SARS-CoV-2 leads to less severe disease in mouse models

Georgia State University researchers have found that the Alpha, Beta and Delta variants of SARS-CoV-2 were substantially more fatal in mouse models than the original strain of the virus that causes COVID-19.

27 Jun 2022

Scientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parameters

Scientists conducted a meta-analysis to study the impacts of COVID-19 on the male reproductive system.

27 Jun 2022

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Researchers constructed a full-length SARS-CoV-2 spike structure in its membrane-bound state to study functionally relevant aspects of its global conformational dynamics.

27 Jun 2022

The prevalence of long-COVID in children and adolescents

A recent study published in the Scientific Reports journal assessed the incidence of long-coronavirus disease (COVID) among adolescents and children.

27 Jun 2022

Scientists develop suitable human cell line for anti-SARS-CoV-2 drug screening

Scientists have described the development of a modified A549 cell line that shows a robust expression of ACE2 and TMPRSS2 and high susceptibility to SARS-CoV-2 infection.

24 Jun 2022

Scientists discover mechanism behind zoonotic transfer of SARS-CoV-2 virus

The original SARS-CoV-2 viral strain that emerged in early 2020 was able to latch on to sugars known as sialic acids, found on the surface of human cells, an ability that later strains did not retain.

24 Jun 2022

Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

A recent article posted to the bioRxiv* preprint server identified numerous efficacious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from convalescent SARS-CoV-2 patients.

23 Jun 2022

SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

22 Jun 2022

ACE2 News and Research

Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

The antiviral effects of thiol drugs in COVID-19

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

Age-specific susceptibility during the Omicron driven, Delta driven, and pre-Delta waves in South Korea

The effects and mechanisms of SARS-CoV-2 on the nervous system

SARS-CoV-2 3CLpro also susceptible to mutations

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

The potential of DNA-based SARS-CoV-2 vaccine candidates

Cell-based assay highlights differences in antibody neutralizing capacity for SARS-CoV-2 variants

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatment

Omicron variant of SARS-CoV-2 leads to less severe disease in mouse models

Scientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parameters

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

The prevalence of long-COVID in children and adolescents

Scientists develop suitable human cell line for anti-SARS-CoV-2 drug screening

Scientists discover mechanism behind zoonotic transfer of SARS-CoV-2 virus

Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

SARS-CoV-2 evades natural killer cell cytotoxic responses

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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