Acute Myeloid Leukemia News and Research

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Acute Myeloid Leukemia (AML) is a rapidly progressing cancer of the blood characterized by the uncontrolled proliferation of immature blast cells in the bone marrow. The Leukemia and Lymphoma Society estimates that over 13,000 new cases of AML were diagnosed and approximately 9,000 deaths from AML occurred in the U.S. during 2007. AML is generally a disease of older adults, and the median age of a patient diagnosed with AML is about 67 years. A majority of elderly patients are not considered candidates for standard induction therapy or decline therapy, resulting in an acute need for new treatment options.

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies."

28 Dec 2023

Survival rates of black patients with leukemia soar with modern therapies

Non-Hispanic Black patients with acute myeloid leukemia (AML) are living longer, now that new therapies are available, according to a study presented by researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center at the 65th American Society of Hematology (ASH) Annual Meeting and Exposition.

11 Dec 2023

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

In a study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, patients recently diagnosed with a common and aggressive form of acute myeloid leukemia reported having improved quality of life when a newly approved drug was part of the treatment plan.

11 Dec 2023

New combinations and targeted therapies for acute myeloid leukemia on the horizon

The treatment landscape for acute myeloid leukemia (AML) is evolving rapidly, as research discoveries at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and other academic cancer centers advance new, more effective therapies for this aggressive blood cancer.

11 Dec 2023

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

A new study from researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations provides insight into the underlying mechanisms of gene mutations commonly seen in patients with myelodysplastic syndromes (MDS) and other myeloid neoplasms.

11 Dec 2023

MD Anderson researchers report early success of novel menin-targeted therapies in leukemia

Two clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated early positive results from novel therapies targeting menin for the treatment of relapsed or refractory acute leukemias with specific genetic alterations.

11 Dec 2023

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

The University of Texas MD Anderson Cancer Center and Rigel Pharmaceuticals, Inc. today announced a multi-year strategic development collaboration to expand the evaluation of olutasidenib in acute myeloid leukemia (AML) and other hematologic cancers.

8 Dec 2023

Scientists unmask molecule that fuels leukemia growth

In a study published in the journal Genes & Diseases, researchers from Beckman Research Institute of City of Hope, explored the impact of m6A modification on the maturation process of precursor microRNAs (pre-miRNAs) and its potential role in tumorigenesis.

4 Dec 2023

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process

In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML.

4 Dec 2023

FDA awards grant for phase 1 clinical trial of experimental AML/MDS treatment

Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)-;two related blood diseases that disproportionally strike older adults-;are notoriously difficult to treat and associated with high relapse rates.

28 Nov 2023

RNA-based therapy shows promise for treating leukemia in animal models

Each year, about 13,000 people in Deutschland are diagnosed with leukemia, an umbrella term that encompasses various forms of blood cancer.

27 Nov 2023

Genetic vulnerability of leukemia cells uncovered

Leukemia is the most common type of cancer in children. Treatment involves intensive chemotherapy, which has severe side effects due to its non-specific mode of action.

22 Nov 2023

Scientists uncover "genomic tug of war" that influences chemotherapy's effectiveness

Some patients with myelodysplastic syndromes, like acute myeloid leukemia, benefit from a chemotherapy drug called decitabine that stunts cancer growth. But many others are resistant to decatibine's effects or become resistant over time.

16 Nov 2023

Novel assay may improve detection and treatment of acute myeloid leukemia

A novel assay that detects a unique molecular marker in patients with acute myeloid leukemia (AML) may revolutionize the way this disease is detected and treated according to a new report in The Journal of Molecular Diagnostics published by Elsevier.

13 Nov 2023

Gut health and leukemia: Exploring the crucial connection between diet and microbiota changes

Gut microbiota's role in leukemia treatment responses is explored, with evidence suggesting diet and prebiotics may help manage microbiota alterations in patients. Diet during pregnancy, breastfeeding, and gut microbiota composition all intersect, potentially influencing leukemia risks and treatment outcomes.

8 Oct 2023

Annual NCCN Congress to focus on latest advances in blood cancer treatment

The National Comprehensive Cancer Network 2023 Annual Congress: Hematologic Malignancies returns to San Francisco this week, for the first time since 2019.

19 Sep 2023

Chemotherapy drug could be repurposed to treat fatal heart failure, computer model suggests

A chemotherapy drug used to fight bone-marrow cancer also has the potential to treat and prevent potentially deadly heart failure, a powerful new drug-screening tool developed at UVA Health suggests.

15 Sep 2023

Vitamin C and D supplementation may reduce AML treatment complications

Patients with acute myeloid leukemia (AML) who received vitamin C and D supplements while undergoing intensive chemotherapy had lower rates of complications, such as infections, bleeding, and inflammation, when compared with similar, previously treated patients who did not receive these supplements.

7 Sep 2023

Chronic inflammation's influence on TP53 mutations in leukemia evolution explored in new study

Researchers performed a multi-omics evaluation of HSPCs obtained from individuals with myeloproliferative neoplasms transforming to TP53-related secondary forms of acute myeloid leukemia.

7 Sep 2023

NCCN publishes new resource on options, benefits of care approaches for pediatric Hodgkin lymphoma

The National Comprehensive Cancer Network today announced the publication of NCCN Guidelines for Patients®: Hodgkin Lymphoma in Children.

22 Aug 2023

Acute Myeloid Leukemia News and Research

Further Reading

GFH009 disrupts growth signals and triggers apoptosis in hematologic malignancies

Survival rates of black patients with leukemia soar with modern therapies

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

New combinations and targeted therapies for acute myeloid leukemia on the horizon

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

MD Anderson researchers report early success of novel menin-targeted therapies in leukemia

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

Scientists unmask molecule that fuels leukemia growth

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process

FDA awards grant for phase 1 clinical trial of experimental AML/MDS treatment

RNA-based therapy shows promise for treating leukemia in animal models

Genetic vulnerability of leukemia cells uncovered

Scientists uncover "genomic tug of war" that influences chemotherapy's effectiveness

Novel assay may improve detection and treatment of acute myeloid leukemia

Gut health and leukemia: Exploring the crucial connection between diet and microbiota changes

Annual NCCN Congress to focus on latest advances in blood cancer treatment

Chemotherapy drug could be repurposed to treat fatal heart failure, computer model suggests

Vitamin C and D supplementation may reduce AML treatment complications

Chronic inflammation's influence on TP53 mutations in leukemia evolution explored in new study

NCCN publishes new resource on options, benefits of care approaches for pediatric Hodgkin lymphoma

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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