Adenocarcinoma News and Research

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Adenocarcinoma is cancer that begins in cells that line certain internal organs and that have gland-like (secretory) properties.

Study provides a potential game-changer in assessing treatment response in pancreatic cancer patients

The statistics for pancreatic cancer are sobering. With a five-year survival rate of only 9%, incidence of the most common type, pancreatic ductal adenocarcinoma (PDAC), is growing and projected to be the second cause of cancer deaths by 2030.

8 Sep 2022

Research identifies a promising path to developing therapies to treat esophageal tumors

Research led by Case Western Reserve University has identified a promising path to developing therapies to treat esophageal tumors––a form of cancer that not only is among the most deadly, but also has been occurring at increasing rates over the past decade.

8 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

Study defines how the circadian clock influences cell growth, metabolism and tumor progression

In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression.

11 Aug 2022

Researchers examine the effect of cumulative exposure to air pollutants with lung cancer diagnosis

Researchers from Vancouver, British Columbia examine the effect of duration of past exposure to air pollution with lung cancer diagnosis.

9 Aug 2022

Study compares the nodule management protocols used in NELSON and National Lung Cancer Screening Trial

The protocol used to screen and detect lung cancer in the NELSON Trial is more sensitive than the protocol used in the National Lung Cancer Screening Trial, particularly for early-stage cancers, according to research reported today at the IASLC World Conference on Lung Cancer 2022 in Vienna.

8 Aug 2022

Researchers examine the incidence of second primary lung cancers using National Lung Screening Trial data

Using data from the National Lung Screening Trial, researchers found that the incidence of second primary lung cancer was approximately 4% among the entire cohort of lung cancer patients and was as high as 8% among patients undergoing surgery for stage IA disease.

8 Aug 2022

Scientists introduce SARS-CoV-2 phenotype screening for identifying novel antiviral drugs

Researchers introduced a phenotypic screening assay for identifying compounds with SARS-CoV-2 inhibition potential based on caspase 3/7 activation.

20 Jul 2022

Discovery about how a certain protein is activated in tumor cells could lead to better treatments

Better treatments for some of cancer's deadliest forms could be closer due to a University of California, Irvine-led discovery about how a certain protein is activated in tumor cells.

19 Jul 2022

Researchers develop an AI system to classify IBD neoplasia lesions accurately

The incidence of inflammatory bowel disease (IBD)-;an intractable disease characterized by chronic inflammation of the gastrointestinal (GI) tract-;has increased significantly in Japan.

13 Jul 2022

GI cancer survival rates improving among Northern Territorians except for Aboriginal and Torres Strait Islander people

Survival rates for gastrointestinal (GI) cancer among Northern Territorians have improved in the past 30 years but Aboriginal and Torres Strait Islander peoples living in the Territory still have worse survival outcomes, a new analysis has found.

8 Jul 2022

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatment

A recent study posted to the bioRxiv* preprint server assessed whether niclosamide could be employed in coronavirus disease 2019 (COVID-19) therapy.

28 Jun 2022

Researchers discover a molecular switch that promotes pancreatic cancer metastasis

More than 62,000 people in the United States will be diagnosed with pancreatic cancer by the end of this year, with the vast majority having a deadly and aggressive subtype known as pancreatic ductal adenocarcinoma (PDA).

27 Jun 2022

Erectile dysfunction drugs may be able to boost the effect of chemotherapy in esophageal cancer

A group of drugs commonly used to treat erectile dysfunction may be able to boost the effect of chemotherapy in esophageal cancer, according to new research funded by Cancer Research UK and the Medical Research Council.

21 Jun 2022

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

A new study that analyzed protein levels in 2,002 primary tumors from 14 tissue-based cancer types identified 11 distinct molecular subtypes, providing systematic knowledge that greatly expands a searchable online database that has become a go-to platform for cancer data analysis by users worldwide.

10 Jun 2022

New FR-targeting, micropinocytosis-mediated bioconjugate attacks K-Ras mutant pancreatic cancer

Often undetected until it has progressed to an advanced stage, pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer.

6 Jun 2022

Chemo-immunotherapy combination shows promise against pancreatic cancer

A combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system was effective against one of the hardest targets in cancer care, pancreatic cancer, in a national, randomized clinical trial led by researchers at the Perelman School of Medicine at the University of Pennsylvania, and sponsored by the Parker Institute for Cancer Immunotherapy.

6 Jun 2022

Aerobic exercise amplifies the effects of immunotherapy to reduce pancreatic tumor growth

Aerobic exercise reprograms the immune system to reduce pancreatic tumor growth and amplify the effects of immunotherapy, a new study finds.

2 Jun 2022

Substances touted to improve athletic performance and high fat diet fuel pancreatic cancer’s development

Researchers at the University of Michigan Rogel Cancer Center have found a cell nuclear receptor activated by high fat diets and synthetic substances in unregulated athletic performance enhancers fuels the progression of precancerous pancreas lesions into pancreatic cancer.

1 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.