Adenovirus News and Research

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Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis, and rash illness. Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress.

Targeted Genetics announces new patent for Hyperlipidemia

Targeted Genetics Corporation announced today issuance of U.S. patent #6,887,463, entitled, "Methods and Compositions for Gene Therapy for the Treatment of Defects in Lipoprotein Metabolism."

11 May 2005

Scientists use transcription factors to increase insulin production in diabetic mice

A group of Japanese scientists has used gene therapy to deliver three insulin transcription factors, MafA, PDX-1, and NeuroD, to the livers of diabetic mice. As a result, the mice experienced an increase in insulin gene expression and insulin production, raising the possibility that this could eventually be used to treat diabetes.

13 Apr 2005

Novel strategy to create a genetic vaccine against P. aeruginosa

Pseudomonas aeruginosa is a bacterium that can cause respiratory tract infections, which can be life threatening in patients who have cystic fibrosis. It is therefore important to develop a vaccine against this pathogen.

3 Apr 2005

Genzyme begins gene transfer trial for peripheral arterial disease

Genzyme Corporation announced today that the first patient has been treated in a new phase 2 clinical trial examining the safety and effectiveness of locally delivered gene transfer for patients with peripheral arterial disease.

24 Feb 2005

Researchers discover way to overcome major hurdle in gene therapy for cancer

In a new study published in the Jan. 25 issue of the Proceedings of the National Academy of Sciences (PNAS), the researchers demonstrated that the technique works by incorporating it into a specially designed virus. The virus eradicated prostate cancer cells in the lab and in animals while leaving normal cells unscathed.

26 Jan 2005

Gene transfer used to deliver antibodies to fight Anthrax

Using gene transfer technology, investigators were able to immunize mice against anthrax in just 12 hours, according to new research featured in the February 2005 issue of Molecular Therapy, the peer-reviewed scientific journal of the American Society of Gene Therapy (ASGT).

12 Jan 2005

Safety established for Vaxin's first flu vaccine in clinical trial

Vaxin Inc., a privately-held biotechnology company, has demonstrated, in a Phase I human clinical study, that the company's recombinant influenza vaccine provides a potential alternative to traditional flu vaccines.

12 Jan 2005

Herpes virus offers new hope in search for cure for cancer

In laboratory studies at Cincinnati Children's Hospital Medical Center, researchers have successfully treated the most common malignant abdominal tumor of childhood: neuroblastoma tumors.

4 Dec 2004

New understanding of how poxviruses jump from species to species

A Canadian study conducted at Robarts Research Institute sheds new light on how poxviruses can jump from species to species -- and will lead to further exploration of another potential candidate in the emerging field of “oncolytic viruses” to fight cancer.

25 Oct 2004

Scientists discover a record number of proteins for the highly infectious and stealthy human cytomegalovirus

Scientists have discovered a record number of proteins for one of the largest and most complex viruses, the highly infectious and stealthy human cytomegalovirus, a team from Pacific Northwest National Laboratory and Oregon Health & Science University reported today in the October Journal of Virology.

29 Sep 2004

Study presents multiple lines of evidence against the proposed link between SV40 and human mesotheliomas

Mesothelioma is an aggressive cancer of the chest cavity that kills about 2000 people a year in the United States.

26 Sep 2004

Nanowires could be used to sense thousands of different viruses

Harvard University scientists have found that ultra-thin silicon wires can be used to electrically detect the presence of single viruses, in real time, with near-perfect selectivity.

22 Sep 2004

Crucell and AIDS Vaccine Initiative have signed an exclusive license agreement to develop an AIDS vaccine

Dutch biotechnology company Crucell and the International AIDS Vaccine Initiative (IAVI) have signed an exclusive license agreement to develop an AIDS vaccine based on Crucell’s AdVac® technology.

20 Sep 2004

First molecular-scale images of DNA binding to an adenovirus enzyme

The images, which appear on the cover of the October 2004 issue of Molecular and Cellular Proteomics, show how binding to DNA may stimulate the enzyme and are already being used to design new antiviral drugs to block this interaction.

14 Sep 2004

Major trends in AIDS research that the different research teams throughout the world are pursuing

The science will be presented during the conference which is taking place in Lausanne until September 1, 2004. The advances in fundamental research, notably through a better understanding of the complex processes of immune defence, HIV and the functioning of vaccines, promote the genesis and development of new vaccine candidates.

30 Aug 2004

Scientists discover breakthrough method to treat neuronal diseases

What do stroke, epilepsy, head or spinal cord trauma, Parkinson’s disease and Alzheimer’s disease patients have in common? They all suffer from neuronal cell death brought about by the absence or malfunction of specific genes.

30 Aug 2004

High-resolution images reveal the molecular rearrangements that rotavirus uses to break into cells

High-resolution images constructed by researchers at Children's Hospital Boston and Harvard Medical School reveal the molecular rearrangements that rotavirus – the most common cause of severe, dehydrating diarrhea and vomiting in children worldwide – uses to break into cells.

25 Aug 2004

Exposure to simian virus 40 (SV40) is not associated with cancer in humans

Two upcoming studies by scientists at the National Cancer Institute (NCI), provide further evidence that exposure to simian virus 40 (SV40) is not associated with cancer in humans.

23 Aug 2004

New treatment strategy for brain cancer

Virginia Commonwealth University Massey Cancer Center researchers have found that combining ionizing radiation with a secreted protein that selectively inhibits tumor cell growth and survival can target cancer cells and leave healthy cells alone, perhaps presenting a new approach for treating the deadliest type of brain tumor.

9 Aug 2004

U.S.$2.8 to study a virus associated with respiratory infections

The Center for Emerging Infectious Diseases (CEID), based in the University of Iowa College of Public Health, has been awarded a five-year, $2.8 million grant by the National Institute of Allergy and Infectious Diseases to study a virus associated with respiratory infections.

11 Jun 2004