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Researchers uncover a new source of energy expending brown fat cells

A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity.

12 Apr 2021

Researchers reveal the positive effects of exercise on the liver

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide, affecting as much as a quarter of humanity. It is characterized by fat accumulation in liver cells and may progress to inflammation, cirrhosis and liver failure.

12 Apr 2021

Obesity reduces mitochondrial gene expression in fat tissue, finds study

A twin study recently completed at the University of Helsinki indicates that the machinery responsible for energy handling in fat tissue is working poorly in obesity.

9 Apr 2021

New stem cell therapy shows promise to prevent diabetes-related amputations

According to the results of a phase 1 clinical trial just published in STEM CELLS Translational Medicine, a new stem cell therapy shows promise of making diabetes-related amputations a thing of the past.

7 Apr 2021

Study paves way for effective monitoring of chemotherapeutic drug level in cancer patients

Cancer is the world's second deadliest disease which contributes towards the fatality of over 10 million people per year.

3 Apr 2021

Study opens door to new approaches for preventing the development of metabolic diseases

The protein Asc-1 regulates whether fat-burning beige or fat-storing white adipocytes are formed, which can have an impact on the development of metabolic diseases.

31 Mar 2021

Fat grafting shows potential to help cancer patients with radiation-induced skin injury

As cancer survival rates improve, more people are living with the aftereffects of cancer treatment. For some patients, these issues include chronic radiation-induced skin injury - which can lead to potentially severe cosmetic and functional problems.

30 Mar 2021

Stem cell depletion could be an important factor behind miscarriage

Depletion of a certain type of stem cell in the womb lining during pregnancy could be a significant factor behind miscarriage, according to a study released today in STEM CELLS.

27 Mar 2021

Weight loss induced by diet and bariatric surgery has different impact on mitochondria in fat tissue

Dieting impairs the energy-producing machinery of fat tissue, potentially resulting in weight regain. In contrast, as indicated by a recently completed European study coordinated by the University of Helsinki, weight loss surgery gives a boost to mitochondria, improving the gene expression of these cellular engines.

18 Mar 2021

Researcher get federal grant to study how gut microbiota and inflammation promote metabolic syndrome

Dr. Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University, has received a four-year federal grant just over $2 million to study how inflammation and altered gut microbiota, the microorganisms living in the intestine, influence the development of a group of diseases referred to as metabolic syndrome.

18 Mar 2021

Allogeneic adipose-derived stem cells can mitigate TBI-induced acute radiation syndrome

Nuclear power offers an efficient, reliable way to provide energy to large populations - as long as all goes well. Accidents involving nuclear reactors such as those that took place in 1986 at Chernobyl and at Fukushima Daiichi after the March 2011 tsunami raise major concerns about what happens if the worst occurs and large numbers of people are simultaneously exposed to high levels of radiation.

16 Mar 2021

Accelerated accumulation of abdominal fat during menopause linked to heart disease risk

Women who experience an accelerated accumulation of abdominal fat during menopause are at greater risk of heart disease, even if their weight stays steady, according to a University of Pittsburgh Graduate School of Public Health-led analysis published today in the journal Menopause.

3 Mar 2021

New technology may help improve tissue restoration outcomes for breast cancer and other diseases

New technology from Purdue University innovators may help improve tissue restoration outcomes for people with breast cancer and other diseases or traumatic injuries.

2 Mar 2021

3D microscopy sheds light on the body’s immune response to obesity

Researchers who focus on fat know that some adipose tissue is more prone to inflammation-related comorbidities than others, but the reasons why are not well understood.

18 Feb 2021

Accumulation of fatty tissue in the neck predicts adiposity, heart problems

Researchers from the University of Granada warn that an accumulation of fatty tissue in the neck (both the double chin and the deeper deposits, located between muscles and around the cervical vertebrae) is a predictor of central and overall adiposity, cardiometabolic risk, and a pro-inflammatory profile in sedentary young adults.

17 Feb 2021

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization

Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body's glucose levels, which is important for the development of metabolic diseases like diabetes.

16 Feb 2021

Lifestyle changes in pregnant women linked to epigenetic alterations in babies

A study led by researchers at Lund University in Sweden showed a connection between lifestyle intervention in pregnant women with obesity and epigenetic alterations in the baby. The study is published in the journal Diabetes.

11 Feb 2021

Pancreatic β cells secrete miR-29 in response to high levels of free fatty acids

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.

9 Feb 2021

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses.

5 Feb 2021

Immune profiling shows differences in COVID-19 and influenza pathologic pathways

A study conducted at Johns Hopkins University School of Medicine in Baltimore has revealed distinct differences in the immune pathways that are activated by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and those that are activated by influenza.

2 Feb 2021