Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

New review highlights advances in diabetes research and treatment

A new paper surveying advances in diabetes pathogenesis and treatment explores the complex factors contributing to the onset and progression of the disease, suggesting that an understanding of these dynamics is key to developing targeted interventions to reduce the risk of developing diabetes and managing its complications.

25 Jul 2024

New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Researchers created a detailed transcriptomic atlas of six brain regions, revealing cell-type-specific and region-specific vulnerabilities in Alzheimer's disease and highlighting astrocyte genes linked to cognitive resilience.

25 Jul 2024

Experimental cancer drug could make thinking easier for individuals with Rett syndrome

An experimental cancer drug could make thinking easier for individuals with Rett syndrome, a rare disorder linked to autism, according to new research from the University of California San Diego -; a discovery that could lead to therapies for patients with other neurological conditions.

25 Jul 2024

Finnish research reveals higher incidence of early-onset dementia among working-age adults

A new major study by the University of Eastern Finland, the University of Oulu and Neurocenter Finland explored early-onset dementia in the working-age population in Finland.

25 Jul 2024

Unprecedented brain cell mapping sheds light on Alzheimer's

Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to create an annotated library of all the gene readouts stored within 100 individual brain cells, the task felt daunting.

25 Jul 2024

Comprehensive analysis of Alzheimer’s brain tissue identifies novel biomarkers

From studying the human genome, to analyzing the way proteins are encoded, or monitoring RNA expression, researchers are rapidly gaining a far richer understanding of the complex genetic and cellular mechanisms that underpin dementia. But there's a catch: While new technologies are revealing myriad avenues for Alzheimer's research, it's impossible to know in advance which research pathways will lead to effective treatments.

25 Jul 2024

Oligodendrocytes identified as key amyloid β producers in Alzheimer's disease

Researchers discovered that oligodendrocytes, not just neurons, produce amyloid β in Alzheimer's disease, and suppressing their activity improves disease pathology. This finding suggests new therapeutic targets for Alzheimer's treatment.

24 Jul 2024

High belly and arm fat linked to Alzheimer's and Parkinson's risk

People with high levels of body fat stored in their belly or arms may be more likely to develop diseases like Alzheimer's and Parkinson's than people with low levels of fat in these areas, according to a study published in the July 24, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology.

24 Jul 2024

Traffic-related ultrafine particles impair mitochondrial function in human olfactory cells

Ultrafine particles, UFPs, the smallest contributors to air pollution, hinder the function of mitochondria in human olfactory mucosa cells, a new study shows.

24 Jul 2024

Creating the first genetically susceptible mice for late-onset Alzheimer's

Mice don't get Alzheimer's-;and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments.

24 Jul 2024

Breakthrough research identifies fibrin as key factor in preterm brain bleeds

Mark Petersen, MD, has seen firsthand the devastating effects of brain bleeds in premature babies. It's an exceedingly common condition that affects up to 20 percent of infants born before 28 weeks of gestation, bringing an increased risk for developmental delays and autism.

24 Jul 2024

WVU researchers explore immune cell interactions in multiple sclerosis

A West Virginia University immunologist is exploring how the interaction between two types of immune cells within the central nervous system covering causes multiple sclerosis to develop.

24 Jul 2024

Comprehensive dataset from A4 study yields key insights about Alzheimer's disease

Data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) study, the first and largest clinical trial of pre-symptomatic Alzheimer's disease, is now widely available to researchers studying the condition.

24 Jul 2024

Review highlights hidden gut-brain connection in neurological disorders

Research reveals the gut microbiota-brain axis as a critical link in understanding and treating neurological disorders through microbial interventions.

23 Jul 2024

Oligodendrocytes identified as key source of amyloid beta in Alzheimer's disease

Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer's disease (AD), according to a study published July 23, 2024 in the open-access journal PLOS Biology by Rikesh Rajani and Marc Aurel Busche from the UK Dementia Research Institute at University College London, and colleagues.

23 Jul 2024

New preclinical model offers a unique platform for studying Parkinson's disease process

A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.

23 Jul 2024

Why millions are trying FDA-authorized alternatives to big pharma’s weight loss drugs

Pharmacist Mark Mikhael has lost 50 pounds over the past 12 months. He no longer has diabetes and finds himself "at my ideal body weight," with his cholesterol below 200 for the first time in 20 years. "I feel fantastic," he said.

23 Jul 2024

USC scientists transform B cells into cancer and HIV destroyers

USC scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.

22 Jul 2024

Saffron: A golden remedy for modern health challenges

Review highlights saffron's potential in preventing and treating various human diseases through its bioactive compounds. Clinical and preclinical studies confirm saffron's benefits in conditions like maculopathy, depression, neurodegenerative diseases, and cancer.

21 Jul 2024

UCLA chosen to lead dementia care under new Medicare alternative payment model

UCLA has been selected by the Centers for Medicare & Medicaid Services (CMS) to participate in a new Medicare alternative payment model designed to support people living with dementia and their caregivers.

19 Jul 2024