Amyloidosis News and Research

RSS

Amyloidosis is the term applied to a group of conditions caused by deposits of an abnormal protein called amyloid. This rare but serious condition affects between 1 and 5 people in every 100,000 each year in the UK. The condition is mainly seen among the elderly.

Associations between gut microbes and Alzheimer’s disease

Researchers reviewed existing data on the role of the gut microbiome in Alzheimer’s disease (AD) pathogenesis.

24 Jul 2024

Heart of the Matter: Early Diagnosis and Intervention in Heart Failure with Prof. Martin Cowie & Dr. Lisa Anderson

The future of heart failure treatment with AstraZeneca's Prof. Martin Cowie and Heart Failure Specialist and Consultant Cardiologist at St George’s Hospital Dr. Lisa Anderson.

17 Jul 2024

Enzymatic RNA synthesis paves the way for sustainable therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

12 Jul 2024

Antibody fragment discovery could lead to much-needed treatment for light chain amyloidosis

In people with a rare condition called light chain amyloidosis, light chain proteins-;which are a component of antibodies-;mutate and build up in different organs.

10 Jul 2024

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Researchers trace the 60-year evolution of lipid nanoparticles (LNPs) for nucleic acid delivery, highlighting their potential to revolutionize gene therapy with safer and more effective treatments.

10 Jul 2024

Study uncovers role of Y chromosome loss in transthyretin cardiac amyloidosis

Researchers at Boston Medical Center (BMC) and Boston University (BU) Chobanian & Avedisian School of Medicine, in collaboration with an international team of scientists, shared findings from a new study published in the American Heart Association journal, Circulation: Heart Failure that explores a common cause of heart disease in older men called transthyretin cardiac amyloidosis (ATTR-CA).

27 Jun 2024

Early diagnosis key in combating the deadly effects of AL amyloidosis

AL (immunoglobulin light chain) amyloidosis is a rare disease that often results in progressive organ dysfunction, organ failure and eventual death.

27 Jun 2024

Japanese study sheds light on genetic counseling for AATRv amyloidosis

Early detection and treatment of hereditary transthyretin-related amyloidosis via genetic counseling are crucial.

13 Jun 2024

Young bone marrow transplants show promise in reversing Alzheimer's symptoms in mice

Researchers found that young bone marrow transplants rejuvenate aging immune cells, reducing Alzheimer's symptoms in mice models, suggesting a potential therapeutic approach for the disease.

4 Jun 2024

Carpal tunnel syndrome as an early warning sign for cardiac amyloidosis

Physician-scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine led a nationwide study to examine the role of carpal tunnel syndrome in predicting the risk of cardiac amyloidosis.

3 Jun 2024

Cardiovascular burden of TTR gene variant among Black carriers across mid to late-life

The key contribution of this study was to provide more accurate estimates of cardiovascular risk across mid to late life, compared to previously existing analyses.

15 May 2024

Genetic variant increases heart failure risk and decreases longevity in Black Americans

Researchers at Brigham and Women’s Hospital and Duke University showed that a genetic variant, present in 3-4% of self-identified Black individuals in the U.S., increases the risk for both heart failure and death and contributes to significant decreases in longevity at the population level.

11 May 2024

MedStar Washington Hospital Center enrolls first U.S. patient in gene-editing therapy trial for heart disease

The first U.S. heart patient involved in a study for a new gene-editing therapy directly infused inside the body has successfully been enrolled at MedStar Washington Hospital Center.

6 May 2024

New AI system can be used to reliably detect cardiac amyloidosis

Cardiac amyloidosis is a serious disease in which abnormal proteins (amyloids) accumulate in the heart muscle and impair heart function.

21 Mar 2024

Comprehensive protein analysis reveals potential targets for treating dialysis-related amyloidosis

Dialysis patients often develop dialysis-related amyloidosis and exhibit bone and joint disorders that impair their activity of daily living.

29 Feb 2024

Scientists discover new genetic cause of inherited kidney disease

Genetic changes or mutations can cause hereditary kidney disease, which can eventually lead to dialysis or the need for kidney transplantation. Identifying the cause of inherited kidney disease is the first step in identifying a treatment.

22 Jan 2024

Groundbreaking drug offers new hope for life-threatening heart condition

People diagnosed with a life-threatening cardiac condition have been given new hope, thanks to a ground-breaking new drug that protects the heart developed by researchers from UCL and the Royal Free Hospital.

11 Jan 2024

Common heart medication causes false positives on Alzheimer's blood test

Researchers from the University of Gothenburg, in collaboration with colleagues from University of Glasgow, present data that the drug Entresto (sacubitril/valsartan) which is commonly used for the treatment of cardiac failure leads to a marked reduction in plasma Aβ ratio, a candidate blood test for Alzheimer's disease (AD).

18 Dec 2023

New insights into the structures formed during antibody aggregation through 3D domain swapping

Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development.

8 Dec 2023

Alzheimer's screening just got easier, more accurate with new blood test

A new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology.

31 Aug 2023