Amyloidosis News and Research

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Amyloidosis is the term applied to a group of conditions caused by deposits of an abnormal protein called amyloid. This rare but serious condition affects between 1 and 5 people in every 100,000 each year in the UK. The condition is mainly seen among the elderly.

Alzheimer's screening just got easier, more accurate with new blood test

A new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology.

31 Aug 2023

Japanese squirrels may be a model for human amyloidosis

A research group led by Dr. Tomoaki Murakami from the Tokyo University of Agriculture and Technology has revealed that fibrinogen Aα-chain amyloidosis, a previously unreported disease in animals other than humans, is highly prevalent in Japanese squirrels (Sciurus lis).

18 Aug 2023

How does the circulating proteome influence brain health?

Researchers investigate the association between the circulating proteome and brain health.

7 Aug 2023

Blood test may help identify patients at risk for transthyretin amyloid cardiomyopathy

A new multi-center study led by doctors at Boston Medical Center and Columbia University found that having a genetic variant in the prealbumin gene alone is not sufficient for diagnosis of transthyretin amyloid cardiomyopathy in older Black patients.

28 Jul 2023

The infection connection: investigating the impact on dementia risk, neuroimaging reveals

Researchers compared the association between neuroimaging markers of dementia and antibodies to common infection.

17 Jul 2023

Monumental $11.5 million gift will enable FAU to find a cure for amyloidosis

Currently, there is no cure for amyloidosis, a life-threatening disease that can be present throughout the body, including the heart, kidneys, liver and brain. The most common localized form of amyloidosis, which is seen significantly more often, is in the brain.

13 Jul 2023

ATTR amyloidosis cardiomyopathy can be reversed, study reports

Three men who had heart failure caused by the build-up of sticky, toxic proteins are now free of symptoms after their condition spontaneously reversed in an unprecedented case described by a team at UCL (University College London) and the Royal Free Hospital.

7 Jun 2023

Factors associated with diagnostic delay in Familial Mediterranean Fever

EULAR – The European Alliance of Associations for Rheumatology – held its 2023 annual congress in Milan, Italy. One of the abstracts chosen for presentation in the scientific session on Rheumatic and Musculoskeletal diseases (RMDs) in children and young people, focused on the factors associated with diagnostic delay in FMF, using data from the Juvenile Inflammatory Rheumatism (JIR) cohort.

31 May 2023

Amyloid-removing drug shows promise for the treatment of stiff-heart syndrome

Transthyretin-related cardiac amyloidosis is a progressive disease characterized by the deposition of amyloid protein fibrils in the heart. Amyloid fibril deposition thickens and stiffens the heart walls, and the disease is also known as stiff-heart syndrome.

22 May 2023

Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Senescence and extracellular vesicles: novel partners in vascular amyloidosis."

29 Mar 2023

A review of innate immunity relevant to SARS-CoV-2 and COVID-19

In a recent study published in The New England Journal of Medicine, researchers reviewed selected acute-phase proteins concerning their production, structure, and function.

7 Feb 2023

Novel amyloid protein discovered from canine mammary tumors

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein from canine mammary tumors.

24 Jan 2023

Protein Medin: A new treatment target for Alzheimer's

A recent study published in the journal Nature reported the co-aggregation of medin, a fragment of lactadherin, with vascular amyloid-β in Alzheimer’s disease (AD).

10 Jan 2023

Gut microbiome plays a role in Alzheimer's

In a recent review published in the journal Pharmacological Research, researchers in Brazil investigated the role of gut microbiota in cognition, brain function, behavior, and neurodegenerative disease pathogenesis.

17 Nov 2022

Novel gene editing therapy reduces circulating TTR protein levels in patients with ATTR amyloid cardiomyopathy

A single IV infusion of NTLA-2001, a novel CRISPR/Cas9-based gene editing therapy, significantly reduced circulating transthyretin (TTR) protein levels in patients with ATTR amyloid cardiomyopathy, a progressive and fatal cause of heart failure, according to late-breaking research presented today at the American Heart Association’s Scientific Sessions 2022.

7 Nov 2022

UC San Diego Health first to offer new injectable medication to patients with hereditary transthyretin amyloidosis

UC San Diego Health is first in the nation to offer a new injectable medication to patients with nerve damage caused by hereditary transthyretin amyloidosis, a rare disease that can be fatal without management.

18 Aug 2022

Stem cell transplantation produces prolonged survival with improved safety in patients with AL amyloidosis

AL amyloidosis is a life-threatening disease related to bone marrow cancer, multiple myeloma. It is caused when a person's antibody-producing white blood cells (i.e. plasma cells) do not function properly and generate abnormal protein which misfolds to form amyloid fibrils and deposits made of components of antibodies called light chains, which then deposit in various organs of the body.

14 Jul 2022

New near-infrared probe may aid in early diagnosis of Alzheimer's disease

Inside the body, some seemingly harmless proteins have sinister potential. In the case of Alzheimer's disease, the amyloid-beta (Aβ) protein, which is vital for brain growth, can become tainted and destroy cells, which leads to forgetfulness and memory loss.

14 Jun 2022

Most blood tests to detect Alzheimer’s disease perform inconsistently across racial groups

Three experimental blood tests used to identify people in early stages of Alzheimer's disease perform differently in Black individuals compared to white individuals, according to a new study from Washington University School of Medicine in St. Louis.

21 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022