Autoantibodies News and Research

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Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

To date, little evidence has been documented regarding the immune responses after the onset of the symptoms or virus detection. Further, no cross-sectional studies have been conducted that define the time of infection. Thereby, no report is available that explains the relationship between the earliest immune responses to COVID-19 and temporal kinetics. New research deals with this research gap using blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing methods.

6 Apr 2021

New ‘SINT1A‘ study explores potential of a probiotic to prevent type 1 diabetes in children

Type 1 diabetes is the most common metabolic disease in children and adolescents worldwide. It can be particularly dangerous as often there is no diagnosis until severe and sometimes life-threatening symptoms have already developed.

26 Mar 2021

Lupus Research Alliance announces recipients of the 2020 Distinguished Innovator Award

The Lupus Research Alliance proudly announces two exceptional recipients of the 2020 Dr. William E. Paul Distinguished Innovator Award in Lupus and Autoimmunity: Jacques Banchereau, PhD and Ignacio Sanz, MD.

25 Mar 2021

Study observes correlation between COVID-19 mortality and autoantibodies in corticosteroid treated patients

Corticosteroid anti-inflammatory drugs have been applied to COVID-19 patients over the course of the pandemic, though the results are mixed. In a recent study, the outcomes for such patients are collated, demonstrating a striking correlation between the development of autoantibodies and mortality.

25 Mar 2021

Study proves that postural orthostatic tachycardia syndrome may be an autoimmune disorder

The symptoms of postural orthostatic tachycardia syndrome, or POTS, can be as varied as they are confounding. There can be fatigue, pain, bleeding disorders and anxiety. Heart palpitations and lightheadedness are common.

16 Mar 2021

Impact of type I interferon (IFN) autoantibodies in critical COVID-19

A new preprint discusses the pathogenesis of this critical COVID-19 with reference to autoimmune phenomena involving the key antiviral type I interferon pathway.

12 Mar 2021

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases

Scientists have recently developed a novel alternative molecular display technology called Molecular Indexing of Proteins by Self Assembly (MIPSA). Their research explains how this technology overcomes the critical disadvantages of PLATO and other full-length protein array technologies.

5 Mar 2021

Coronavirus deranges the immune system in complex and deadly ways

There's a reason soldiers go through basic training before heading into combat: Without careful instruction, green recruits armed with powerful weapons could be as dangerous to one another as to the enemy.

4 Mar 2021

Anti-phospholipid antibodies in severely ill patients not distinctive to COVID-19, says study

A new study by researchers at the University of Toronto and the University of Calgary in Canada indicates that the presence of these antibodies correlates with more severe COVID-19 symptoms and signs.

25 Feb 2021

COVID-19 may alter host proteins to cause autoimmunity

To better understand the transient and chronic autoimmune symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, researchers from Memorial Sloan Kettering Cancer Center, Guizhou Medical University, and biotech company Curandis embarked on an endeavor to establish a comprehensive autoantigenome for COVID19.

23 Feb 2021

Slight differences can help distinguish between two similar pediatric brain conditions

Slight differences in clinical features can help physicians distinguish between two rare but similar forms of autoimmune brain inflammation in children, a new study by UT Southwestern scientists suggests.

23 Feb 2021

Mucosal delivery of IFNs a good strategy for COVID-19 prophylaxis post-exposure

Researchers from the UK and Germany recently reported a comprehensive characterization of the SARS-CoV-2 response of human nasal epithelial cells, revealing a response dominated by IFN-I/IIIs. Also, recombinant IFN-I/III treatment was found to efficiently block the replication of SARS-CoV-2, which suggests that mucosal delivery of IFNs may be a good strategy for prophylaxis post-exposure.

22 Feb 2021

Juvenile inflammatory rheumatic disease associated with higher antibody responses to seasonal coronaviruses

A new study released on the bioRxiv* server compared the antibodies produced in young patients with these three conditions against the two immunodominant coronavirus antigens, the spike and the nucleocapsid antigens.

19 Feb 2021

UIC researchers receive $10.15 million grant to develop treatment for dry eye conditions

Researchers at University of Illinois Chicago have been awarded a five-year, $10.15 million grant to develop a broad-spectrum immunomodulatory eye drop to treat patients with severe dry eye and ocular surface disease due to inflammatory and immune system disorders.

9 Feb 2021

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), is associated with several clinical features common in autoimmune diseases as myalgias, arthralgias, fatigue, and rashes. COVID-19 patients also exhibit less common autoimmunity manifestations such as myositis, thrombosis, myocarditis, encephalitis, vasculitis, and arthritis.

1 Feb 2021

Machine learning identifies patterns of maternal autoantibodies associated with autism

Using machine learning, researchers at the UC Davis MIND Institute have identified several patterns of maternal autoantibodies highly associated with the diagnosis and severity of autism.

26 Jan 2021

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

With the emergence of COVID-19 (coronavirus disease 2019), researchers have been closely investigating the complex interplay between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the human immune system, and COVID-19 disease severity.

25 Jan 2021

Autoantibodies News and Research

Is non-severe SARS-CoV-2 infection characterized by early T cell proliferation?

New ‘SINT1A‘ study explores potential of a probiotic to prevent type 1 diabetes in children

Lupus Research Alliance announces recipients of the 2020 Distinguished Innovator Award

Study observes correlation between COVID-19 mortality and autoantibodies in corticosteroid treated patients

Study proves that postural orthostatic tachycardia syndrome may be an autoimmune disorder

Impact of type I interferon (IFN) autoantibodies in critical COVID-19

Identification of neutralizing IFNL3 autoantibodies in severe COVID-19 cases

Coronavirus deranges the immune system in complex and deadly ways

Anti-phospholipid antibodies in severely ill patients not distinctive to COVID-19, says study

COVID-19 may alter host proteins to cause autoimmunity

Slight differences can help distinguish between two similar pediatric brain conditions

Mucosal delivery of IFNs a good strategy for COVID-19 prophylaxis post-exposure

Juvenile inflammatory rheumatic disease associated with higher antibody responses to seasonal coronaviruses

UIC researchers receive $10.15 million grant to develop treatment for dry eye conditions

SARS-CoV-2 triggers development of new-onset IgG autoantibodies in hospitalized COVID-19 patients

Machine learning identifies patterns of maternal autoantibodies associated with autism

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

Experts advise disaggregating data on COVID-19 patients by sex

How do SARS-CoV-2 antibodies change over time in recovered patients?

Main bioactive compound of ginger root may protect against autoimmune disease progression

Immunology eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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