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Coding and noncoding genes are involved in and cooperate in human tumorigenesis

A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood.

11 Sep 2007

Researchers make new discovery on pigment melanin and skin - hair color

The pigment melanin, which is responsible for skin and hair color in mammals, is produced in specialized cells called melanocytes and then distributed to other cells. But not every cell in the complex layers of skin becomes pigmented.

10 Sep 2007

New insights into the complexity of HIV/AIDS

Three related papers published in the Sept. 1 edition of The Journal of Immunology provide key new insights into the complexity of HIV/AIDS. Don Sodora, Ph.D., a principal investigator in SBRI's Viral Vaccines Program who recently joined SBRI from the University of Texas, Southwestern Medical Center, is senior author on one of three papers that collectively show CD4 T-cell depletion, a critical symptom of AIDS, is likely a part of a multifaceted scenario that triggers disease rather than the only cause.

10 Sep 2007

Scientists shed new light on how antibodies fight HIV

By furthering scientists' understanding of the molecular mechanisms that separate the minority of successful HIV antibodies from the majority of ineffective antibodies, the work may have implications for future attempts to design an HIV vaccine.

10 Sep 2007

Schizophrenia-linked gene keeps new adult brain cells under control

The study reveals that the gene, known as Disrupted-In-Schizophrenia 1 (DISC1), directs the incorporation of new neurons into the adult brain and keeps the process under control. The gene's newly discovered roles might help to explain why schizophrenia's symptoms generally arise in adolescence or early adulthood, the researchers suggested.

10 Sep 2007

Researchers develop mouse model of autism spectrum disorders

Howard Hughes Medical Institute researchers have genetically engineered mice that harbor the same genetic mutation found in some people with autism and Asperger syndrome.

10 Sep 2007

Innovative liquid crystal technology offers promise of new drugs

A partnership between Kent State University, Summa Health System and IC-MedTech Inc. has yielded an innovative liquid crystal technology that offers the promise of new drugs which may more effectively manage cancer and other diseases.

10 Sep 2007

Discovery of tendon cells that self-renew

Athletes know that damage to a tendon can signal an end to their professional careers. But a consortium of scientists, led in part by USC School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics - including the ability to proliferate and self-renew.

10 Sep 2007

Mutated mice provide new insights into autism

Mice containing a mutated human gene implicated in autism exhibit the poor social skills but increased intelligence akin to the title character's traits in the movie “Rain Man,” researchers at UT Southwestern Medical Center have found.

10 Sep 2007

Research looks at prions and retroviruses

National Research Center for Environment and Health in Neuherberg/Munich (Helmholtz Association of German Research Centres) the group is continuing to search for cellular components whose make-up is changed as a result of a prion infection.

10 Sep 2007

New understanding of role of schizophrenia risk gene DISC1 in normal adult brains

How the gene that has been pegged as a major risk factor for schizophrenia and other mood disorders that affect millions of Americans contributes to these diseases remains unclear.

10 Sep 2007

Bad news for disease-causing bacteria!

Scientists have what could be some very bad news for disease-causing bacteria. All three major classes of antibiotics that kill infectious bacteria do so in part by ramping up the production of harmful free radicals, researchers report in the September 7, 2007, issue of Cell, a publication of Cell Press.

10 Sep 2007

Clearer picture of how a dividing cell rebuilds the nuclear envelope

Just how a dividing cell rebuilds the nuclear envelope, the protective, functional wrapping that encases both the original and newly copied genetic material, has been a source of controversy for the last 20 years.

10 Sep 2007

A molecular probe that may one day light up tumors while surgery is in progress

Researchers at the Stanford University School of Medicine have developed a molecular probe that sets aglow tumor cells within living animals. Their goal is to use the probe to improve the diagnosis and treatment of cancer and other diseases.

10 Sep 2007

New technique for growing cartilage from human embryonic stem cells

Rice University biomedical engineers have developed a new technique for growing cartilage from human embryonic stem cells, a method that could be used to grow replacement cartilage for the surgical repair of knee, jaw, hip, and other joints.

10 Sep 2007

A chink in bacteria's armor

Biomedical researchers at Boston University's College of Engineering may have discovered the path toward developing better drugs capable of defeating so-called “superbugs,” bacteria that have developed resistance to common antibiotics. The researchers have discovered a previously unknown chain of events occurring in bacteria that opens to door to new avenues of research.

10 Sep 2007