Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Lower levels in plasma of biomarkers beta-amyloid 42/40 increase rate of cognitive decline

Older adults without dementia and with lower levels in plasma of the biomarkers beta-amyloid 42/40 (protein fragments) had an increased rate of cognitive decline over a period of 9 years, according to a study in the January 19 issue of JAMA. The researchers also found that this relationship was stronger among individuals with less education and lower levels of literacy.

19 Jan 2011

Molecular imaging procedure may detect beta-amyloid in brain, increase accuracy of AD diagnosis

Preliminary research suggests that use of a type of molecular imaging procedure may have the ability to detect the presence of beta-amyloid in the brains of individuals during life, a biomarker that is identified during autopsy to confirm a diagnosis of Alzheimer disease, according to a study in the January 19 issue of JAMA.

19 Jan 2011

First Round Table Meeting on Metabolomics & Diabetes takes place in Vienna

Metabolomic biomarker research is a young research area that carries great hopes for both medicine and the nutritional sciences, particularly for the early detection of genetically determined diseases.

14 Jan 2011

MGH researchers discover massive overexpression of DNA sequences in cancer cells

Massachusetts General Hospital Cancer Center researchers have discovered a previously unknown feature of common tumor cells - massive overexpression of certain DNA sequences that do not code for proteins.

14 Jan 2011

Research study to develop rapid, inexpensive blood screening test for early diagnosis of pancreatic cancer

A clinical research study to develop a rapid and inexpensive blood screening test for the early diagnosis of pancreatic cancer has been launched by Henry Ford Health System and the Barbara Ann Karmanos Cancer Institute.

14 Jan 2011

Epigenomics concludes feasibility phase in development of improved product concept for Epi proColon

Epigenomics AG, the cancer molecular diagnostic company, today announced that it has concluded the feasibility phase in the development of an improved product concept for Epi proColon, the Company's DNA methylation-based blood test for assistance in the detection of individuals with colorectal cancer.

13 Jan 2011

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

A Blanchette Rockefeller Neurosciences Institute study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.

12 Jan 2011

Study reveals underlying causes for degeneration of synapses in Alzheimer's Disease

A Blanchette Rockefeller Neurosciences Institute (BRNI) study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.

12 Jan 2011

Vermillion receives USPTO patent for PAD biomarker

Vermillion, Inc., a molecular diagnostics company, today announced that the United States Patent and Trademark Office has issued patent number 7,867,719 entitled "Beta-2 microglobulin as a biomarker for peripheral artery disease" to the Company.

12 Jan 2011

Positive results from Allovectin-7 Phase 3 trial in patients with metastatic melanoma

Vical Incorporated today announced a new publication summarizing results from the company's completed trials of Allovectin-7 including systemic responses and an excellent safety profile in patients with metastatic melanoma.

11 Jan 2011

BioScale announces results of two pharmacodynamic biomarkers using assay AMMP technology

BioScale, an innovative life science company that develops, manufactures and promotes novel analytical tools enabling advancements in protein research, announced that results from the analysis of two pharmacodynamic biomarkers using the Acoustic Membrane MicroParticles assay technology on the ViBE Protein Analysis Workstation were published in the peer-reviewed Elsevier Journal of Analytical Biochemistry.

11 Jan 2011

Study to identify early warning biomarkers for presence of breast and prostate cancers

Using biological samples taken from patients and state-of-the-art biochemical techniques, a Florida State University researcher is working to identify a variety of "biomarkers" that might provide earlier warnings of the presence of breast and prostate cancers.

11 Jan 2011

Takeda, Zinfandel enter global licensing agreement for TOMM40 biomarker assay for Alzheimer's disease

Takeda Pharmaceutical Company Limited and Zinfandel Pharmaceuticals, Inc. today announced that they have entered into an exclusive, worldwide licensing agreement regarding Zinfandel's TOMM40 assay as a biomarker for the risk of Alzheimer's disease in high-risk older adults with normal cognition. The companies will study pioglitazone in connection with the TOMM40 biomarker and Alzheimer's disease.

11 Jan 2011

QIAGEN to acquire minority stake in Alacris Theranostics

QIAGEN has signed an agreement for the acquisition of a strategic stake in Alacris Theranostics GmbH, a German start-up company using novel technologies to develop individualized cancer treatment strategies based upon a patient's genomic profile, and for the acquisition of an exclusive option to access all biomarkers emerging from this discovery program.

From QIAGEN Manchester Limited 11 Jan 2011

USDTL launches two new tests for monitoring long-term alcohol exposure using fingernail, hair specimens

United States Drug Testing Laboratories launched two new tests for monitoring long-term alcohol exposure on Friday. Using fingernail and hair specimens, the new assay is the first and only test to report a donor's alcohol exposure for the past 90 days reliably.

10 Jan 2011

Critical Diagnostics' high sensitivity Presage ST2 Assay receives CE Mark approval

Critical Diagnostics announced today that it has received CE (Conformité Européenne) Mark for its high sensitivity Presage ST2 Assay and is commencing commercialization in Europe. The product is indicated for use as an aid in risk stratification of patients with heart failure or acute coronary syndrome. This regulatory milestone marks the first time that an assay has become commercially available for the clinical measurement of the biomarker soluble ST2.

7 Jan 2011

BG Medicine enters agreement to develop galectin-3 test for Siemens' automated immunoassay platforms

BG Medicine, Inc. announced today that it has entered into an agreement with Siemens Healthcare Diagnostics Inc., a division of Siemens Healthcare, one of the world's largest suppliers of clinical diagnostics to the healthcare industry, for the development and commercialization of a galectin-3 test for Siemens' automated immunoassay platforms for clinical laboratories.

7 Jan 2011

Biomarker study yields diagnostic blood test candidate for detection of Alzheimer's disease

OPKO Health, Inc. today announced the publication of a biomarker study yielding its diagnostic blood test candidate for the detection of Alzheimer's disease.

7 Jan 2011

Metabolon announces publication of 'Metabolomic Distinction and Insights into the Pathogenesis of Human Primary Dilated Cardiomyopathy'

Metabolon, the leader in metabolomics, biomarker discovery and analysis, announces the publication of "Metabolomic Distinction and Insights into the Pathogenesis of Human Primary Dilated Cardiomyopathy", in the European Journal of Clinical Investigation.

6 Jan 2011

New technique to analyze and quantify changes in protein

A scientist from the Florida campus of The Scripps Research Institute has devised a new method of analyzing and quantifying changes in proteins that result from a common chemical process. The new findings could provide new insights into the effects of a highly destructive form of stress on proteins in various disease models, particularly cancer.

6 Jan 2011

Biomarker News and Research

Further Reading

Lower levels in plasma of biomarkers beta-amyloid 42/40 increase rate of cognitive decline

Molecular imaging procedure may detect beta-amyloid in brain, increase accuracy of AD diagnosis

First Round Table Meeting on Metabolomics & Diabetes takes place in Vienna

MGH researchers discover massive overexpression of DNA sequences in cancer cells

Research study to develop rapid, inexpensive blood screening test for early diagnosis of pancreatic cancer

Epigenomics concludes feasibility phase in development of improved product concept for Epi proColon

Study indicates disease's underlying causes in mice, finds compounds that normalize Alzheimer's brain

Study reveals underlying causes for degeneration of synapses in Alzheimer's Disease

Vermillion receives USPTO patent for PAD biomarker

Positive results from Allovectin-7 Phase 3 trial in patients with metastatic melanoma

BioScale announces results of two pharmacodynamic biomarkers using assay AMMP technology

Study to identify early warning biomarkers for presence of breast and prostate cancers

Takeda, Zinfandel enter global licensing agreement for TOMM40 biomarker assay for Alzheimer's disease

QIAGEN to acquire minority stake in Alacris Theranostics

USDTL launches two new tests for monitoring long-term alcohol exposure using fingernail, hair specimens

Critical Diagnostics' high sensitivity Presage ST2 Assay receives CE Mark approval

BG Medicine enters agreement to develop galectin-3 test for Siemens' automated immunoassay platforms

Biomarker study yields diagnostic blood test candidate for detection of Alzheimer's disease

Metabolon announces publication of 'Metabolomic Distinction and Insights into the Pathogenesis of Human Primary Dilated Cardiomyopathy'

New technique to analyze and quantify changes in protein

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