Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Unique genetic markers point to patient response to SCV-07 treatment

SciClone Pharmaceuticals, Inc. (NASDAQ: SCLN) today announced that researchers have identified two unique gene clusters that differentiated subjects who responded to treatment in the Company’s phase 2a proof of concept study of SCV-07 for the prevention of severe oral mucositis (OM; WHO grades 3-4) in patients with advanced head and neck cancer.

29 Sep 2010

Omicsoft's Next Generation Sequencing tools integrated with GeneGo's MetaCore data mining suite

GeneGo, Inc., the leading systems biology tools company and Omicsoft Corporation, the leader in the OMIC repository and analysis field, announced today integration of Omicsoft's Next Generation Sequencing tools with GeneGo's MetaCore data mining suite.

29 Sep 2010

XOMA completes patient enrollment in XOMA 052 Phase 2a trial

XOMA Ltd., a leader in the discovery and development of therapeutic antibodies, announced that patient enrollment was recently completed for the company's Phase 2a trial of XOMA 052 in patients with Type 2 diabetes.

29 Sep 2010

Circulating tumor cells may be promising alternative for tumor biopsies

Circulating tumor cells (CTCs) may be a promising alternative, noninvasive source of tumor materials for biomarker assessment, according to data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

29 Sep 2010

KINAXO, Daiichi Sankyo enter long-term partnership in cancer research

KINAXO Biotechnologies GmbH and Daiichi Sankyo Company Limited entered a long-term partnership in cancer research. Under the agreement, Daiichi Sankyo will employ KINAXO's technology platform to support the development of Daiichi Sankyo's targeted cancer drugs.

29 Sep 2010

Researchers identify biomarker to predict tivozanib drug resistance

Researchers believe there may be a way to predict, based on individual tumors, those patients that are more likely to respond to the investigational new drug tivozanib.

29 Sep 2010

Loss of INPP5A gene can predict cutaneous squamous cell carcinoma progression

The loss of a gene known as INPP5A could predict the onset, and track the progression, of an aggressive type of skin cancer, according to a study published today by the Mayo Clinic, Arizona Cancer Center, and the Translational Genomics Research Institute (TGen).

29 Sep 2010

Researchers discover new diagnostic test for prostate cancer

Researchers in England say they have discovered a set of biomarkers that can distinguish prostate cancer from benign prostate disease and healthy tissue with 90 percent accuracy.

From Oxford Gene Technology 29 Sep 2010

Triple-negative breast cancer patients may have unique biomarker to receive targeted therapy: Research

Patients with triple negative breast cancer, one of the hardest subtypes to treat, may have a unique biomarker that would enable them to receive more targeted therapy, according to data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

29 Sep 2010

NCI awards A&G $1.2M Phase II SBIR grant for development of breast cancer drug candidate

A&G Pharmaceutical announced today that it has received $1.2 million in Phase II Small Business Innovation Research (SBIR) funding from the National Cancer Institute (NCI) for the program, "Novel Targeted Therapy for Breast Cancer," focused on the development of a neutralizing therapeutic antibody against a novel cancer-associated protein, GP88.

29 Sep 2010

Family members, friends are more sensitive to early signs of Alzheimer's dementia: Researchers

Family members and close friends are more sensitive to early signs of Alzheimer's dementia than traditional screening tests, according to researchers at Washington University School of Medicine in St. Louis.

28 Sep 2010

NPL, Orla receives fund to improve detection methods for TB

Two UK companies have been awarded joint funding for a research project that could see significant advances in the quest to aid detection and eradication of Tuberculosis (TB), across the world.

28 Sep 2010

Michael J. Fox Foundation launches PPMI clinical study to identify Parkinson's disease biomarkers

The Michael J. Fox Foundation has launched the Parkinson's Progression Markers Initiative (PPMI), the first ever large scale clinical study exclusively focused on identifying and validating Parkinson's disease biomarkers.

28 Sep 2010

Genomics obtains worldwide rights to The Garvan Institute of Medical Research's methylation DNA biomarkers

Clinical Genomics Pty. Ltd (Sydney, Australia) and The Garvan Institute of Medical Research (Sydney, Australia) today announced that they have entered into a license agreement in relation to novel biomarkers discovered by scientists at the Garvan Institute. Under the terms of the agreement, Clinical Genomics obtains worldwide exclusive rights to the Garvan's proprietary cancer associated methylation DNA biomarkers for the diagnosis and or treatment of colorectal cancer.

28 Sep 2010

BMC physicians to lead international research collaboration to curb infectious diseases

Boston Medical Center (BMC) has been chosen to lead an investigation aimed at developing novel approaches to prevent tuberculosis (TB). Jerrold J. Ellner, MD, chief of the section of infectious diseases at BMC and professor of medicine at the Boston University School of Medicine (BUSM), a renowned expert in the field, will serve as principal investigator (PI) on the five-year, $3 million grant funded by the National Institutes of Health (NIH).

27 Sep 2010

Clinical Data announces Stedivaze agonist data at ASNC2010 meeting

Clinical Data, Inc., today presented data from Phase I studies of Stedivaze (apadenoson), which demonstrated overall safety and tolerability in patients with asthma and chronic obstructive pulmonary disease (COPD).

27 Sep 2010

Enobia announces positive results from ENB-0040 Phase II juvenile clinical trial for hypophosphatasia

Enobia Pharma today announced positive results for its Phase II juvenile clinical trial of ENB-0040 (asfotase alfa), an experimental bone-targeted enzyme replacement therapy intended for the treatment of hypophosphatasia (HPP). Hypophosphatasia is a rare, inherited, and sometimes fatal metabolic bone disease that affects individuals of all ages.

24 Sep 2010

CIC proposes criteria to improve endpoints for cancer immunotherapy trials

The Cancer Research Institute (CRI) Cancer Immunotherapy Consortium (CIC), the leading global initiative in advancing the emerging field of immuno-oncology, has proposed criteria for improved endpoints for cancer immunotherapy trials, which were published online on September 8 in the Journal of the National Cancer Institute.

24 Sep 2010

Boehringer Ingelheim, Eurofins Medigenomix partner in DNA banking and pharmacogenetics, pharmacogenomics

Boehringer Ingelheim Pharma GmbH & Co. KG, an international research-driven pharma company, and Eurofins Medigenomix GmbH, a competence center for genetic analyses of the Eurofins Scientific Group, concluded a long-term service agreement in the area of DNA banking, as well as a master service agreement for pharmacogenetic and pharmacogenomic services. For DNA banking Eurofins Medigenomix is supporting operations of Boehringer Ingelheim's central DNA bank at Biberach an der Riss.

23 Sep 2010

Metabolon publishes biomarker validation study results for periodontal diseases

Metabolon, Inc., leaders in global metabolomics, biomarker discovery and biochemical analysis, announces the publication of "Assessment of Dentifrice on Periodontal Disease Biomarkers in Gingival Crevicular Fluid", in the Journal of Periodontology.

23 Sep 2010

Biomarker News and Research

Further Reading

Unique genetic markers point to patient response to SCV-07 treatment

Omicsoft's Next Generation Sequencing tools integrated with GeneGo's MetaCore data mining suite

XOMA completes patient enrollment in XOMA 052 Phase 2a trial

Circulating tumor cells may be promising alternative for tumor biopsies

KINAXO, Daiichi Sankyo enter long-term partnership in cancer research

Researchers identify biomarker to predict tivozanib drug resistance

Loss of INPP5A gene can predict cutaneous squamous cell carcinoma progression

Researchers discover new diagnostic test for prostate cancer

Triple-negative breast cancer patients may have unique biomarker to receive targeted therapy: Research

NCI awards A&G $1.2M Phase II SBIR grant for development of breast cancer drug candidate

Family members, friends are more sensitive to early signs of Alzheimer's dementia: Researchers

NPL, Orla receives fund to improve detection methods for TB

Michael J. Fox Foundation launches PPMI clinical study to identify Parkinson's disease biomarkers

Genomics obtains worldwide rights to The Garvan Institute of Medical Research's methylation DNA biomarkers

BMC physicians to lead international research collaboration to curb infectious diseases

Clinical Data announces Stedivaze agonist data at ASNC2010 meeting

Enobia announces positive results from ENB-0040 Phase II juvenile clinical trial for hypophosphatasia

CIC proposes criteria to improve endpoints for cancer immunotherapy trials

Boehringer Ingelheim, Eurofins Medigenomix partner in DNA banking and pharmacogenetics, pharmacogenomics

Metabolon publishes biomarker validation study results for periodontal diseases

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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