Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

$20.7 million to make smallpox vaccine safer

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded a five-year, $20.7 million grant to National Jewish Medical and Research Center to lead a consortium of academic medical centers trying to make smallpox vaccines safer for millions of people with atopic dermatitis, also known as eczema.

19 May 2004

Inexpensive, simple urine test that could identify impending kidney failure

Johns Hopkins researchers have developed the basis of an inexpensive, simple urine test that identifies impending kidney failure or rejection following transplant surgery. Their work, presented this week in a special invited lecture to the American Transplant Congress in Boston, Mass., is based on proteins found in urine, and could lead to a urine test kit that may allow many patients to skip painful biopsies.

19 May 2004

Critical link found between inflammation, heart disease and stroke

Until recently, the story on platelets was pretty simple: tiny blood cells, with limited sophistication because they had no nucleus, and their claim to fame was to be a first-responder to a wound site, to promote healthy clotting and prevent infection.

11 May 2004

New studies on the diagnosis of interstitial cystitis and the treatment of prostatitis

Antimicrobials Ineffective in Treating Chronic Prostatitis / Pelvic Pain Syndrome (CP/PPS): Though the traditional means of treating men with CP/PPS, use of antibiotics and alpha-adrenergic receptor blockers (tamsulosin and ciprofloxacin) did not lead to significant change after six and 12 weeks of treatment.

10 May 2004

Wine may reduce the risk of ovarian cancer

Scientists at The Queensland Institute of Medical Research (QIMR) have determined that moderate wine intake may reduce the risk of ovarian cancer.

29 Apr 2004

Increased blood levels of a heart cell “stress” protein called ST2 were linked to a higher risk of death

Increased blood levels of a heart cell “stress” protein called ST2 were linked to a higher risk of death and congestive heart failure in the 30 days after a heart attack, researchers report in today’s rapid access issue of Circulation: Journal of the American Heart Association.

29 Apr 2004

Potential new drug may slow the progression of the Parkinson's disease

An international team of Parkinson's disease researchers has shown that a potential new drug is effective at treating patients in the early stages of Parkinson's and may even slow the progression of the disease. The results from the Parkinson Study Group are in the April 19 issue of the Archives of Neurology.

22 Apr 2004

Marker predicts patients who are seven times more likely to die after suffering a heart attack

Researchers at Brigham and Women’s Hospital (BWH) have found a protein in the blood that may one day produce a simple and inexpensive test to help determine who is at high risk for problems following a heart attack.

22 Apr 2004

New drug is effective at treating patients in the early stages of Parkinson’s

An international team of Parkinson’s disease researchers has shown that a potential new drug is effective at treating patients in the early stages of Parkinson’s and may even slow the progression of the disease.

20 Apr 2004

Identification of first protein biomarkers to help patients with amyotrophic lateral sclerosis

A University of Pittsburgh pathologist has identified the first protein biomarkers able to diagnose patients with amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) with near 100 percent accuracy. Before this finding, there were no known diagnostic biomarkers for this neurodegenerative disease.

18 Apr 2004

Vitamin C can reduce levels of C-reactive protein, a marker of inflammation and chronic disease

Vitamin C supplements can reduce levels of C-reactive protein, a marker of inflammation and chronic disease risk in humans, according to a new study led by researchers at the University of California, Berkeley.

12 Apr 2004

Extraction of RNA from Archived Formalin-Fixed, Paraffin-Embedded Tissue

For the first time, Fox Chase Cancer Center researchers have demonstrated the ability to extract RNA from formalin-fixed, paraffin-embedded tissue samples archived for up to five years. What's more, the technology used retrieves high-quality samples, allowing researchers to identify cancer-related genetic changes. Accepted as a "late-breaking" abstract, the research was presented today at the 95th Annual Meeting of the American Association for Cancer Research by Renata Coudry, M.D., a research pathologist at Fox Chase Cancer Center.

30 Mar 2004

New research to predict patient response to cancer chemotherapies

Timothy J. Yeatman, M.D., Moffitt's Associate Center Director for Clinical Investigations at the H. Lee Moffitt Cancer Center & Research Institute, and the Sarasota-based DNAPrintTM genomics, Inc., have formed a joint research program to develop and implement new clinical tests for predicting patient response to cancer chemotherapies.

29 Mar 2004

Simple blood tests which could predict the severity of osteoarthritis

Bristol researchers are hoping to develop simple blood tests which could predict the severity of osteoarthritis, a common, disabling joint condition which affects more than two million people in the UK.

29 Mar 2004

Carbon Dioxide may be used in medical implants

Carbon dioxide, an environmentally friendly solvent for dyeing and dry cleaning, may become a valuable new tool for making medical implants, according to a study at Ohio State University.

23 Mar 2004