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Completion of the sequencing of human chromosome 19

The United States Department of Energy (DOE) Joint Genome Institute (JGI) and Stanford University report today the completion of the sequencing of human chromosome 19, the most gene-rich of all the human chromosomes. This achievement is described in the April 1, 2004 edition of the journal Nature.

7 Apr 2004

Patients with coronary artery blockages can be treated safely using drug coated stents

The researchers followed 155 consecutive patients treated with multiple sirolimus-eluting stents between April 2002 and March 2003. Each patient had at least two lesions blocking blood flow in different coronary arteries. Earlier studies have demonstrated that patients with a single, simple artery narrowing held open with a sirolimus-eluting stent are less likely to need retreatment than similar patients who received a bare metal stent. However, those studies excluded patients with complex or multiple artery lesions.

6 Apr 2004

Oral sildenafil improved exercise tolerance, cardiac output and quality of life in 22 patients with primary pulmonary hypertension

Oral sildenafil (Viagra®) improved exercise tolerance, cardiac output and quality of life in 22 patients with primary pulmonary hypertension, according to the results of the first randomized, placebo-controlled, double-blind, crossover study, reported in the April 7, 2004 issue of the Journal of the American College of Cardiology.

6 Apr 2004

New method to induce embryonic stem cells to develop into bone marrow and blood cells

Researchers at Northwestern University have devised a method to induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, including cells of the immune system, which normally are created in the bone marrow.

6 Apr 2004

New York - Due to changing blood donor criteria, donor deferral rates have been increasing since 1999

Due to changing blood donor criteria, donor deferral rates have been increasing since 1999 with trend lines predicting additional deferral increases. This predicament has created a critical demand for new people to step forward to donate to ensure there is an adequate supply of blood for hospital patients in New York and New Jersey who require life-saving transfusions, reports New York Blood Center (NYBC) officials.

6 Apr 2004

Alzheimer's live about half as long as those of similar age without dementia

Age, seriousness of impairment, and the severity of other medical conditions are important indicators of how long an individual might survive after an Alzheimer's disease diagnosis, Eric B. Larson, M.D., M.P.H. and colleagues report in the April 6 Annals of Internal Medicine. Study authors include Linda Teri, Ph.D., recipient of an Alzheimer's Association $1 million Pioneer research grant.

6 Apr 2004

Number of breaths given during CPR may be linked to survival

Researchers have identified a factor that may improve cardiac arrest survival rates according to a first-of-its-kind study of paramedic responses reported in today’s rapid access issue of Circulation: Journal of the American Heart Association.

5 Apr 2004

Fluorescent molecule used to examine real time chemical reactions that result in smooth-muscle contraction

Smooth muscle, found in the walls of blood vessels and in internal organs such as lungs, stomach and the bladder, contracts as the end result of a series of chemical reactions. In a new study, UT Southwestern researchers report that one set of chemical reactions resulting in the contraction of the smooth-muscle cells is augmented by a second chemical pathway that kicks in when the first pathway is limited.

5 Apr 2004

More evidence needed to link symptoms like tics or behavioral problems to a strep infection

Michigan opens new center to treat exposure to Vermiculite, Taconite, Asbestos

In response to the United States Environmental Protection Agency's (EPA) identification of major sources of public asbestos exposure in Michigan, the Barbara Ann Karmanos Cancer Institute and the Center for Occupational and Environmental Medicine (COEM) affiliated with Wayne State University (WSU) have joined forces to establish The National Center for Vermiculite and Asbestos-Related Cancers.

5 Apr 2004

New device filters blood supplies on-site reducing the possible transmission of Creutzfeldt-Jakob disease

ProMetic Life Sciences Inc. has announced today that its joint venture with the American Red Cross, Pathogen Removal and Diagnostic Technology Inc. ("PRDT"), has confirmed that treatment of TSE spiked red blood cell concentrate with its Prion Reduction Device results in a significant decrease in associated infectivity.

5 Apr 2004

First Approval in Europe of Ezetimibe/Simvastatin for treatment of elevated cholesterol

Merck/Schering-Plough Pharmaceuticals today announced the regulatory approval of INEGYTM (ezetimibe/simvastatin) in Germany for the treatment of elevated cholesterol (hypercholesterolemia). INEGY is the first product to reduce low-density lipoprotein cholesterol (LDL-C or ‘bad’ cholesterol), along with diet and exercise, through dual inhibition by inhibiting cholesterol production in the liver and absorption in the intestine. The approval of INEGY in Germany represents the first approval in Europe for ezetimibe/simvastatin tablets and the first step in seeking marketing approval throughout the European Union (EU) under the EU’s mutual recognition procedure.

4 Apr 2004

Study Looks at Risk Factors for Range-of-Motion Limitations In Young Males with Hemophilia

A paper in the April issue of Blood detailed research on the prevalence and risk factors joint range of motion (ROM) limitation among young males with hemophilia.

4 Apr 2004

New center enables genetic treatments and advances

A new state-of-the-art research facility dedicated to helping produce modified cells for treatment of cancer and other diseases recently opened at the Siteman Cancer Center.

1 Apr 2004

Whites and African-American pain thresholds most likely the same

Previous research and anecdotal clinical evidence have suggested that African-Americans tend to be more sensitive to pain than Whites, but the latest research study shows the two groups simply interpret standard pain rating scales differently. The new study also confirms earlier findings that women are more sensitive to pain than men.

1 Apr 2004

Innovation that could help sufferers of Raynaud's Phenomenon

A student will display his "smart gloves" as part of the University of Dundee's annual exhibition of honours and research projects for students of Electronic and Electrical Engineering, Physics and Mechanical Engineering on Wednesday 31st March.

31 Mar 2004

Oxford Biomedica to win Department of Health gene funding

Oxford spinout Oxford Biomedica was yesterday awarded £0.5 million by the Department of Health to conduct the first British gene therapy haemophilia trial.

31 Mar 2004

How rat's genetic blueprint stacks up against those of mice and humans

An international research team, supported by the National Institutes of Health (NIH), today announced it has completed a high-quality, draft sequence of the genome of the laboratory rat, and has used that data to explore how the rat's genetic blueprint stacks up against those of mice and humans.

31 Mar 2004

Gene-rich human Chromosome 19 sequence completed

31 Mar 2004

Heart disease can be reduced substantially by regularly treating existing gum infections

Reinforcing the relationship between periodontal disease and heart disease, oral biologists from the University at Buffalo have shown that levels of two inflammatory proteins known to raise the risk of heart disease can be reduced substantially by regularly treating existing gum infections.

31 Mar 2004

Blood News and Research

Completion of the sequencing of human chromosome 19

Patients with coronary artery blockages can be treated safely using drug coated stents

Oral sildenafil improved exercise tolerance, cardiac output and quality of life in 22 patients with primary pulmonary hypertension

New method to induce embryonic stem cells to develop into bone marrow and blood cells

New York - Due to changing blood donor criteria, donor deferral rates have been increasing since 1999

Alzheimer's live about half as long as those of similar age without dementia

Number of breaths given during CPR may be linked to survival

Fluorescent molecule used to examine real time chemical reactions that result in smooth-muscle contraction

More evidence needed to link symptoms like tics or behavioral problems to a strep infection

Michigan opens new center to treat exposure to Vermiculite, Taconite, Asbestos

New device filters blood supplies on-site reducing the possible transmission of Creutzfeldt-Jakob disease

First Approval in Europe of Ezetimibe/Simvastatin for treatment of elevated cholesterol

Study Looks at Risk Factors for Range-of-Motion Limitations In Young Males with Hemophilia

New center enables genetic treatments and advances

Whites and African-American pain thresholds most likely the same

Innovation that could help sufferers of Raynaud's Phenomenon

Oxford Biomedica to win Department of Health gene funding

How rat's genetic blueprint stacks up against those of mice and humans

Gene-rich human Chromosome 19 sequence completed

Heart disease can be reduced substantially by regularly treating existing gum infections

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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