Cancer Immunotherapy News and Research

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Immunotherapy response in patients with advanced melanoma depends on prior treatments

Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.

10 Apr 2023

Regulatory T cell populations descend from two different origins, finds study

A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children's Hospital of Philadelphia (CHOP).

7 Apr 2023

How nanomedicine is revolutionizing care for cardiovascular disease

Researchers review recent advancements in nanomedicine treatment options for cardiovascular disease.

6 Apr 2023

Phase 2 study shows safety and efficacy of new drug in men with high-risk prostate cancers

A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

International panel develops standardized definitions of immunotherapy side effects

An international panel of oncology and immunotherapy experts led by RCSI's Professor Jarushka Naidoo, has developed standardized definitions of the side effects of cancer immunotherapy to assist clinicians in treating patients.

5 Apr 2023

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

Researchers explored the correlation between autoimmunity and obesity.

3 Apr 2023

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) are widely sought after for the treatment of different types of cancers. Unfortunately, only 20–30% patients with cancer respond to ICI treatment.

29 Mar 2023

Leaving lymph nodes intact until after immunotherapy could boost efficacy against solid tumors

Cancer treatment routinely involves taking out lymph nodes near the tumor in case they contain metastatic cancer cells.

20 Mar 2023

Novel immunotherapeutic strategies to target the complex tumor immune microenvironment in head and neck cancer

A symposium aiming to provide a better understanding of the tumor microenvironment, immune tolerogenic niches at cancer initiation, and novel immunotherapeutic strategies in head and neck cancer patients was featured at the 52nd Annual Meeting & Exhibition of the AADOCR, held in conjunction with the 47th Annual Meeting of the CADR.

20 Mar 2023

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

A new approach that delivers a "one-two punch" to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Mar 2023

Study suggests a new way to develop intra-tumor immunotherapies to fight head and neck cancer

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health have identified a strong association between the product of a gene expressed in most cancers, including the most common type of head and neck cancer, and elevated levels of white blood cells that produce antibodies within tumors.

13 Mar 2023

Components of the gut microbiome could be used to better predict efficacy of CAR-T cell therapy

Even though, according to recent preliminary studies, the risk of dying from cancer has declined within the European Union in recent years, cancers remain among the leading causes of death.

13 Mar 2023

Researchers explore potential new target for cancer immunotherapy

A new study posted to the bioRxiv* preprint server, focused on the role of YAP in regulating MHC-I APM expression within tumor cells.

27 Feb 2023

Can the gut microbiota and metabolome explain variation in anti-SARS-CoV-2 vaccination responses in immunosuppressed IBD patients?

Researchers explored the connection between the metabolic function of the gut microbiota, its composition, and immune response to SARS-CoV-2 vaccination in IBD patients.

27 Feb 2023

UTA professor leads a CPRIT-funded study to better craft a personalized cancer immunotherapy

A University of Texas at Arlington bioengineering professor is leading a state-funded project that will try to identify what T-cells are detecting in cancerous cells to better craft a personalized cancer immunotherapy.

23 Feb 2023

Study identifies a previously unknown role of 'natural killer' immune cells

Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of 'natural killer' (NK) immune cells.

10 Feb 2023

MIT study helps shed light on why the immune system mounts a dull response to lung cancer

Immunotherapy -; drug treatment that stimulates the immune system to attack tumors -; works well against some types of cancer, but it has shown mixed success against lung cancer.

3 Feb 2023

MD Anderson and Federation Bio collaborate to design and manufacture a synthetic microbial consortium

The University of Texas MD Anderson Cancer Center and Federation Bio today announced a strategic collaboration to design and manufacture a complex, synthetic microbial consortium with the goal of expanding the number of cancer patients who respond to immunotherapy.

1 Feb 2023

Cancer immunotherapy does not interfere with COVID-19 immunity in vaccinated patients, study shows

Research findings published in Frontiers in Immunology show that cancer immunotherapy does not interfere with COVID-19 immunity in previously vaccinated patients.

31 Jan 2023

Cancer Immunotherapy News and Research

Immunotherapy response in patients with advanced melanoma depends on prior treatments

Regulatory T cell populations descend from two different origins, finds study

How nanomedicine is revolutionizing care for cardiovascular disease

Phase 2 study shows safety and efficacy of new drug in men with high-risk prostate cancers

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

International panel develops standardized definitions of immunotherapy side effects

Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

Diverse subset of T-cell clones plays a role in the antitumor effects of immune checkpoint inhibitors

Leaving lymph nodes intact until after immunotherapy could boost efficacy against solid tumors

Novel immunotherapeutic strategies to target the complex tumor immune microenvironment in head and neck cancer

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

Study suggests a new way to develop intra-tumor immunotherapies to fight head and neck cancer

Components of the gut microbiome could be used to better predict efficacy of CAR-T cell therapy

Researchers explore potential new target for cancer immunotherapy

Can the gut microbiota and metabolome explain variation in anti-SARS-CoV-2 vaccination responses in immunosuppressed IBD patients?

UTA professor leads a CPRIT-funded study to better craft a personalized cancer immunotherapy

Study identifies a previously unknown role of 'natural killer' immune cells

MIT study helps shed light on why the immune system mounts a dull response to lung cancer

MD Anderson and Federation Bio collaborate to design and manufacture a synthetic microbial consortium

Cancer immunotherapy does not interfere with COVID-19 immunity in vaccinated patients, study shows

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Expanding research and clinical options for children with cancer

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