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New method can rapidly determine virus infectivity

A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics.

23 Jul 2024

Breakthrough malaria vaccines RTS,S and R21 poised to save thousands of lives

Research paper reviews the efficacy of the first licensed malaria vaccines, RTS,S and R21, highlighting their potential to significantly reduce childhood mortality and discussing future vaccine development strategies.

21 Jul 2024

Breakthrough gene therapy offers hope for Duchenne muscular dystrophy

A new gene therapy treatment for Duchenne muscular dystrophy shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles.

18 Jul 2024

MPA-CF3: A marine-derived compound disrupting COPZ1 to combat EV-A71

This study is spearheaded by researcher Wu Zhong (National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing) and Prof. Yong Qin (West China School of Pharmacy, Sichuan University).

26 Jun 2024

Gyros Protein Technologies introduces Gyrolab Generic Anti-AAV Kit to support gene therapy development

Ready-to-use kit enables detection of binding antibodies against AAV vectors without the need for serotype-specific assays.

From Gyros Protein Technologies AB 17 Jun 2024

How Epstein-Barr virus shapes immune responses in multiple sclerosis

Study found that EBV-specific immune responses in MS patients showed higher IgG titers and cell-mediated reactions to EBV antigens compared to healthy controls, suggesting a complex role of EBV in MS development.

9 Jun 2024

Gene therapy trial: restored hearing in children with hereditary deafness

The safety and effectiveness of binaural adeno-associated virus 1 (AAV1)-human otoferlin (hOTOF) therapy in five children with autosomal recessive deafness 9 (DFNB9).

7 Jun 2024

Why use light scattering to analyze proteins and viral vectors?

In this interview, Dr. Michelle Chen, Senior Director of Analytical Sciences at Wyatt Technology, talks to NewsMedical about how to use light scattering techniques to analyze proteins for their multi-attribute quantification (MAQ).

From Waters | Wyatt Technology 29 May 2024

Novel gene-delivery vehicle shows promise for treating brain disorders

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.

16 May 2024

New SARS-CoV-2 KP.2 variant defies vaccines with higher spread, study warns

Study on the bioRxiv server reports that the SARS-CoV-2 KP.2 variant, despite lower infectivity, shows significant immune resistance and higher transmissibility compared to other variants, potentially impacting global public health and vaccine efficacy.

29 Apr 2024

Adeno-associated virus: The gene therapy revolution faces manufacturing and safety hurdles

Recombinant adeno-associated virus (rAAV)-based genetic applications to treat human diseases.

5 Apr 2024

T1-spanin breakthrough offers new hope against antibiotic resistance

Given the worldwide prevalence of drug-resistant bacteria, the research fraternity is on the lookout for alternative bactericidal treatment approaches.

12 Mar 2024

HIV virus found to possess hidden transport ability

Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year.

27 Jan 2024

Study reveals how HIV squirms its way into the nucleus during cell invasion

Because viruses have to hijack someone else's cell to replicate, they've gotten very good at it-;inventing all sorts of tricks.

25 Jan 2024

Study reveals new mechanism by which rotavirus induces diarrhea

Rotavirus causes gastroenteritis, a condition that includes diarrhea, deficient nutrient absorption and weight loss. Severe cases result in approximately 128,000 deaths annually in infants and children worldwide.

11 Dec 2023

Empowering oncology research: Transmembrane proteins and cutting-edge production platforms

In this Interview, Dr. Fang-Yi Chu talks to NewsMed about the role of transmembrane proteins in targeting oncology research.

From Sino Biological Inc. 23 Nov 2023

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

Temperature plays crucial role in virus DNA release and infection

Researchers at Lund University, together with colleagues at the NIST Synchrotron Facility in the USA, have mapped on an atomic level what happens in a virus particle when the temperature is raised.

8 Nov 2023

New gene therapy strategy shows promise for Parkinson's disease

Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) and their collaborators have developed a gene therapy strategy to selectively manipulate Parkinson's disease-affected circuitry and attenuate the core motor symptoms of Parkinson's disease in rodent and nonhuman primate animals.

2 Nov 2023

Engineered adeno-associated virus vector yields high transduction of the brain vasculature

Researchers have developed an engineered adeno-associated virus (AAV) vector that yields high transduction of brain vascular pericytes and smooth muscle cells.

24 Aug 2023