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Researchers provide comprehensive molecular characterization of head and neck cancers

In what is believed to be the most comprehensive molecular characterization to date of the most common type of head and neck cancer, researchers from the Johns Hopkins departments of pathology and oncology, the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine, and 18 other centers around the U.S. and Poland have clarified the contribution of key cancer-associated genes, proteins and signaling pathways in these cancers, while proposing possible new treatment avenues.

7 Jan 2021

Researchers apply AI to help physicians customize treatments for patients with oral cancers

Researchers at Case Western Reserve University and partners in the United States and India are applying the investigative and predictive capabilities of artificial intelligence (AI) to help physicians customize treatments for patients with oral squamous cell carcinomas.

5 Jan 2021

Study measures the effects of HIV infection on development of cervical cancer

A research team at the Technical University of Munich (TUM) has quantified the effects of an infection with the Human Immunodeficiency Virus (HIV) on the development of cervical cancer.

22 Dec 2020

Evolutionary gene mutation unique to humans may be to blame for risk of advanced cancers

Compared to chimpanzees, our closest evolutionary cousins, humans are particularly prone to developing advanced carcinomas -- the type of tumors that include prostate, breast, lung and colorectal cancers -- even in the absence of known risk factors, such as genetic predisposition or tobacco use.

9 Dec 2020

Study reveals human-specific link between advanced carcinomas and a unique gene

Humans are more prone to develop carcinomas compared with our closest evolutionary cousins, the great apes.

9 Dec 2020

Inherited DNA defects cause squamous cell carcinoma in kids with Fanconi anemia

Physicians and scientists at Cincinnati Children's Hospital Medical Center used new stem cell technology to regenerate and study living patient-specific skin in the lab.

24 Nov 2020

Study shows potential of new pinprick blood test for diagnosing HPV-related cancers

A potential breakthrough in the early detection of the neck, head and anal cancers linked to human papilloma viruses has emerged.

12 Nov 2020

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Oncotarget recently published "Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer" which reported that the authors investigated whether Trop-2-expression and homologous recombination repair of SN-38-mediated double-strand DNA breaks play a role in the sensitivity of triple-negative breast cancer to SG.

3 Nov 2020

Study: Mammary basal cell lineage contributes to breast cancer heterogeneity

A key hurdle in treating breast cancers is intratumoral heterogeneity, or the presence of multiple different cell populations within the same tumor that have distinct characteristics such as gene expression, metabolism and ability to divide, spread and grow.

29 Oct 2020

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Neoadjuvant, or pre-surgical, combination treatment with the immune checkpoint inhibitors tremelimumab (anti-CTLA-4) and durvalumab (anti-PD-1) was well-tolerated and showed early signs of activity in certain patients with localized bladder cancer who do not have standard treatment options available, according to a Phase I clinical trial conducted by The University of Texas MD Anderson Cancer Center.

13 Oct 2020

Chemists suggest a new domino reaction to produce organic compounds against cancers

A team of chemists from RUDN University suggested a new reaction to produce organic compounds in one vessel.

9 Oct 2020

Immunotherapy benefits patients with gastric and esophageal cancers, new data shows

New data presented at ESMO 2020 have shown that immunotherapy is beneficial for patients with gastric and esophageal cancers who currently have poor survival.

21 Sep 2020

First clinical trial could become an effective way to deliver chemotherapy to abdominal cancer patients

City of Hope surgical researchers are the first in the nation to open a clinical trial that could one day become an effective way to deliver chemotherapy to abdominal cancer patients who currently have very few treatment options.

11 Aug 2020

Investigational drug shows promising results for treating HNSCC tumors

Head and neck cancer is one of the leading causes of cancer-related deaths worldwide, and squamous cell carcinomas (HNSCC) account for the majority of these cases.

31 Jul 2020

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that IQGAP1 is a signaling scaffold implicated in TNBC, but its mechanism is unknown.

30 Jun 2020

Carcinomas News and Research

Researchers provide comprehensive molecular characterization of head and neck cancers

Researchers apply AI to help physicians customize treatments for patients with oral cancers

Study measures the effects of HIV infection on development of cervical cancer

Evolutionary gene mutation unique to humans may be to blame for risk of advanced cancers

Study reveals human-specific link between advanced carcinomas and a unique gene

Inherited DNA defects cause squamous cell carcinoma in kids with Fanconi anemia

Study shows potential of new pinprick blood test for diagnosing HPV-related cancers

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Study: Mammary basal cell lineage contributes to breast cancer heterogeneity

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Chemists suggest a new domino reaction to produce organic compounds against cancers

Immunotherapy benefits patients with gastric and esophageal cancers, new data shows

First clinical trial could become an effective way to deliver chemotherapy to abdominal cancer patients

Investigational drug shows promising results for treating HNSCC tumors

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

Rice lab's fluorescent tag project reveals new method to kill tumors

Researchers evaluate survivin expression in neuroendocrine tumors

New technique offers high-resolution 3D view inside tumors

Scientists discover how an obscure protein promotes breast cancer progression

Exposure to fine particulate matter can increase mortality in young patients with certain cancers

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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